Hedgehog signaling in humans: the HH_Signal pathway_db knowledge base [0.03%]
刺猬信号在人类中的作用：HH_Signal通路数据库知识库
T A Bukharina,A M Bondarenko,D P Furman
T A Bukharina
The rapid advancement of omics technologies (genomics, transcriptomics, proteomics, metabolomics) and other high-throughput methods for experimental studies of molecular genetic systems and processes has led to the generation of an unpreced...
Identification of proteins regulating phenotype-associated genes of M2 macrophages: a bioinformatic analysis [0.03%]
M2型巨噬细胞表型相关基因调控蛋白的生物信息学分析及鉴定
E A Antropova,I V Yatsyk,P S Demenkov et al.
E A Antropova et al.
Macrophages are immune system cells that perform various, often opposing, functions in the organism depending on the incoming microenvironment signals. This is possible due to the plasticity of macrophages, which allows them to radically al...
Computer modeling of spatial dynamics and primary genetic divergence for a population system in a ring areal [0.03%]
环形区域中群体系统的空间动态及原始遗传分化的计算机模拟
M P Kulakov,O L Zhdanova,E Ya Frisman
M P Kulakov
One of the main goals of modern evolutionary biology is to understand the mechanisms that lead to the initial differentiation (primary divergence) of populations into groups with genetic traits. This divergence requires reproductive isolati...
Senescent cell accumulation is associated with T-cell imbalance in the skin [0.03%]
衰老细胞积累与皮肤T细胞失衡相关
K S Matveeva,S K Kolmykov,T S Sokolova et al.
K S Matveeva et al.
Organismal aging is accompanied by the accumulation of senescent cells - damaged, non-functional cells that exhibit cell cycle arrest, resistance to apoptosis, metabolic dysfunction, and production of a wide range of pro-inflammatory substa...
Identification and analysis of the connection network structure between the components of the immune system in children [0.03%]
儿童免疫系统组件间连接网络结构的识别与分析
D S Grebennikov,A P Toptygina,G A Bocharov
D S Grebennikov
Identification of the connections between the various functional components of the immune system is a crucial task in modern immunology. It is key to implementing the systems biology approach to understand the mechanisms of dynamic changes ...
The effect of dimeric bisbenzimidazoles on the activity of DNA repair enzymes TDP1, TDP2, PARP1 and PARP2 [0.03%]
二聚体双苯并咪唑对DNA修复酶TDP1、TDP2、PARP1和PARP2活性的影响
N S Dyrkheeva,I A Chernyshova,A F Arutyunyan et al.
N S Dyrkheeva et al.
Oncological diseases remain a leading cause of pathological mortality worldwide, making the development of anticancer drugs a critical focus in medicinal chemistry. A promising strategy to enhance therapeutic efficacy and reduce chemotherap...
Prediction of interactions between the SARS-CoV-2 ORF3a protein and small-molecule ligands using the ANDSystem cognitive platform, graph neural networks, and molecular modeling [0.03%]
使用ANDSystem认知平台、图神经网络和分子建模预测SARS-CoV-2 ORF3a蛋白与小分子配体的相互作用
T V Ivanisenko,P S Demenkov,M A Kleshchev et al.
T V Ivanisenko et al.
In recent years, artificial intelligence methods based on the analysis of heterogeneous graphs of biomedical networks have become widely used for predicting molecular interactions. In particular, graph neural networks (GNNs) effectively ide...
OrthoML2GO: homology-based protein function prediction using orthogroups and machine learning [0.03%]
基于直系同源簇和机器学习的蛋白质功能预测方法OrthoML2GO
E V Malyugin,D A Afonnikov
E V Malyugin
In recent years, the rapid growth of sequencing data has exacerbated the problem of functional annotation of protein sequences, as traditional homology-based methods face limitations when working with distant homologs, making it difficult t...
Reconstruction and analysis of the gene network regulating apoptosis in hepatocellular carcinoma based on scRNA-seq data and the ANDSystem knowledge base [0.03%]
基于单细胞RNA测序数据和ANDSystem知识库的肝癌凋亡调控基因网络重建与分析
A V Adamovskaya,I V Yatsyk,M A Kleshchev et al.
A V Adamovskaya et al.
Hepatocellular Carcinoma (HCC) is the most common primary liver cancer characterized by rapid progression, high mortality rate and therapy resistance. One of the key areas in studying the molecular mechanisms of HCC development is the analy...
Molecular dynamic analysis of the functional role of amino acid residues V99, F124 and S125 of human DNA dioxygenase ABH2 [0.03%]
人源DNA二氧合酶ABH2第99、124和125位氨基酸残基功能作用的分子动力学分析
M Zhao,T E Tyugashev,A T Davletgildeeva et al.
M Zhao et al.
The ABH2 enzyme belongs to the AlkB-like family of Fe(II)/α-ketoglutarate-dependent dioxygenases. Various non-heme dioxygenases act on a wide range of substrates and have a complex catalytic mechanism involving α-ketoglutarate and an Fe(I...