Computer reconstruction of gene networks controlling anxiety levels in humans and laboratory mice [0.03%]
计算机重构控制人类和实验室小鼠焦虑水平的基因网络
E G Vergunov,V A Savostyanov,A A Makarova et al.
E G Vergunov et al.
Anxiety is a normotypic human condition, and like any other emotion has an adaptive value. But excessively high or low anxiety has negative consequences for adaptation, which primarily determines the importance of studying these two extreme...
Diurnal fluctuations in the content of soluble sugars and the expression of the TAI and LIN6 invertase genes and the STP1 sugar transporter gene in the leaves of the tomato (Solanum lycopersicum L.) [0.03%]
番茄(Solanum lycopersicum L.)叶片中可溶性糖含量以及TAI和LIN6转化酶基因和STP1糖转运基因表达的日变化
M A Filyushin,A V Shchennikova,E Z Kochieva
M A Filyushin
The content of hexoses (fructose, glucose) essential for the fruit of the tomato (Solanum lycopersicum L.) is regulated by the joint activity of sucrose hydrolysis enzymes (including invertases), invertase inhibitors, and sugar transporters...
A concept of natural genome reconstruction.Part 2. Effect of extracellular double-stranded DNA fragments on hematopoietic stem cells [0.03%]
关于从头合成自然基因组的概念。第2部分。细胞外双链DNA片段对造血干细胞的影响
V S Ruzanova,S G Oshikhmina,A S Proskurina et al.
V S Ruzanova et al.
In this part of the study, the first component of the concept of "natural genome reconstruction" is being proven. It was shown with mouse and human model organisms that CD34+ hematopoietic bone marrow progenitors take up fragments of extrac...
Reconstruction and computational analysis of the microRNA regulation gene network in wheat drought response mechanisms [0.03%]
基于干旱胁迫下小麦microRNA的靶基因预测及基因调控网络分析
M A Kleshchev,A V Maltseva,E A Antropova et al.
M A Kleshchev et al.
Drought is a critical factor limiting the productivity of bread wheat (Triticum aestivum L.), one of the key agricultural crops. Wheat adaptation to water deficit is ensured by complex molecular genetic mechanisms, including the coordinated...
Computational identification of promising genetic markers associated with molecular mechanisms of reduced rice resistance to Rhizoctonia solani under excess nitrogen fertilization using gene network reconstruction and analysis methods [0.03%]
基于基因网络重建和分析方法的氮肥过量条件下水稻抗尖孢镰刀菌潜在分子机制遗传标记的计算识别
E A Antropova,A R Volyanskaya,A V Adamovskaya et al.
E A Antropova et al.
Although nitrogen fertilizers increase rice yield, their excess can impair plant resistance to diseases, particularly sheath blight caused by Rhizoctonia solani. This pathogen can destroy up to 50 % of the crop, but the mechanisms underlyin...
N L Podkolodnyy,O A Podkolodnaya,V A Ivanisenko et al.
N L Podkolodnyy et al.
To systematize and effectively use the huge volume of experimental data accumulated in the field of bioinformatics and biomedicine, new approaches based on ontologies are needed, including automated methods for semantic integration of heter...
GlucoGenes®, a database of genes and proteins associated with glucose metabolism disorders, its description and applications in bioinformatics research [0.03%]
GlucoGenes®：一个与葡萄糖代谢紊乱相关基因和蛋白质数据库及其在生物信息学研究中的描述和应用
V V Klimontov,K S Shishin,R A Ivanov et al.
V V Klimontov et al.
Data on the genetics and molecular biology of diabetes are accumulating rapidly. This poses the challenge of creating research tools for a rapid search for, structuring and analysis of information in this field. We have developed a web reso...
Orthoweb: a software package for evolutionary analysis of gene networks [0.03%]
Orthoweb：一个基因网络进化分析软件包
R A Ivanov,A M Mukhin,F V Kazantsev et al.
R A Ivanov et al.
This article introduces Orthoweb (https://orthoweb.sysbio.cytogen.ru/), a software package developed for the calculation of evolutionary indices, including phylostratigraphic indices and divergence indices (Ka/Ks) for individual genes as we...
A novel approach to analyzing the evolution of SARS-CoV-2 based on visualization and clustering of large genetic data compactly represented in operative memory [0.03%]
一种基于可视化和聚类分析SARS-CoV-2进化的新方法并在操作记忆中紧凑表示大量遗传数据
A Yu Palyanov,N V Palyanova
A Yu Palyanov
SARS-CoV-2 is a virus for which an outstanding number of genome variants were collected, sequenced and stored from sources all around the world. Raw data in FASTA format include 16.8 million genomes, each ≈29,900 nt (nucleotides), with a t...
Search for and functional annotation of multi-domain PLA2 family proteins in flatworms [0.03%]
平板 worm 中多结构域 PLA2 家族蛋白质的鉴定与功能注释
M E Bocharnikova,I I Turnaev,D A Afonnikov
M E Bocharnikova
The phospholipase A2 (PLA2) is a superfamily of hydrolases that catalyze the hydrolysis of phospholipids and play a key role in many molecular processes in the cells and the organism as a whole. This family consists of 16 groups divided int...