Identification and analysis of the connection network structure between the components of the immune system in children [0.03%]
儿童免疫系统组件间连接网络结构的识别与分析
D S Grebennikov,A P Toptygina,G A Bocharov
D S Grebennikov
Identification of the connections between the various functional components of the immune system is a crucial task in modern immunology. It is key to implementing the systems biology approach to understand the mechanisms of dynamic changes ...
The effect of dimeric bisbenzimidazoles on the activity of DNA repair enzymes TDP1, TDP2, PARP1 and PARP2 [0.03%]
二聚体双苯并咪唑对DNA修复酶TDP1、TDP2、PARP1和PARP2活性的影响
N S Dyrkheeva,I A Chernyshova,A F Arutyunyan et al.
N S Dyrkheeva et al.
Oncological diseases remain a leading cause of pathological mortality worldwide, making the development of anticancer drugs a critical focus in medicinal chemistry. A promising strategy to enhance therapeutic efficacy and reduce chemotherap...
Prediction of interactions between the SARS-CoV-2 ORF3a protein and small-molecule ligands using the ANDSystem cognitive platform, graph neural networks, and molecular modeling [0.03%]
使用ANDSystem认知平台、图神经网络和分子建模预测SARS-CoV-2 ORF3a蛋白与小分子配体的相互作用
T V Ivanisenko,P S Demenkov,M A Kleshchev et al.
T V Ivanisenko et al.
In recent years, artificial intelligence methods based on the analysis of heterogeneous graphs of biomedical networks have become widely used for predicting molecular interactions. In particular, graph neural networks (GNNs) effectively ide...
OrthoML2GO: homology-based protein function prediction using orthogroups and machine learning [0.03%]
基于直系同源簇和机器学习的蛋白质功能预测方法OrthoML2GO
E V Malyugin,D A Afonnikov
E V Malyugin
In recent years, the rapid growth of sequencing data has exacerbated the problem of functional annotation of protein sequences, as traditional homology-based methods face limitations when working with distant homologs, making it difficult t...
Reconstruction and analysis of the gene network regulating apoptosis in hepatocellular carcinoma based on scRNA-seq data and the ANDSystem knowledge base [0.03%]
基于单细胞RNA测序数据和ANDSystem知识库的肝癌凋亡调控基因网络重建与分析
A V Adamovskaya,I V Yatsyk,M A Kleshchev et al.
A V Adamovskaya et al.
Hepatocellular Carcinoma (HCC) is the most common primary liver cancer characterized by rapid progression, high mortality rate and therapy resistance. One of the key areas in studying the molecular mechanisms of HCC development is the analy...
Molecular dynamic analysis of the functional role of amino acid residues V99, F124 and S125 of human DNA dioxygenase ABH2 [0.03%]
人源DNA二氧合酶ABH2第99、124和125位氨基酸残基功能作用的分子动力学分析
M Zhao,T E Tyugashev,A T Davletgildeeva et al.
M Zhao et al.
The ABH2 enzyme belongs to the AlkB-like family of Fe(II)/α-ketoglutarate-dependent dioxygenases. Various non-heme dioxygenases act on a wide range of substrates and have a complex catalytic mechanism involving α-ketoglutarate and an Fe(I...
Searching for biological processes as targets for rheumatoid arthritis targeted therapy with ANDSystem, an integrated software and information platform [0.03%]
运用AND系统软件和信息平台寻找生物过程作为类风湿性关节炎靶向治疗的靶点
E L Mishchenko,I V Yatsyk,P S Demenkov et al.
E L Mishchenko et al.
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by joint involvement with progressive destruction of cartilage and bone tissue. To date, RA remains an incurable disease that leads to a significant deterior...
Linking hierarchical classification of transcription factors by the structure of their DNA-binding domains to the variability of their binding site motifs [0.03%]
通过其DNA结合域的结构将转录因子的层次分类与其结合位点基序的变化性联系起来
V G Levitsky,T Yu Vatolina,V V Raditsa
V G Levitsky
De novo motif search is the main approach for determining the nucleotide specificity of binding of the key regulators of gene transcription, transcription factors (TFs), based on data from massive genome-wide sequencing of their binding sit...
Self-learning virtual organisms in a physics simulator: on the optimal resolution of their visual system, the architecture of the nervous system and the computational complexity of the problem [0.03%]
物理模拟器中的自学习虚拟生物体：关于其视觉系统的最佳分辨率、神经系统结构以及该问题的计算复杂度
M S Zenin,A P Devyaterikov,A Yu Palyanov
M S Zenin
Vision plays a key role in the lives of various organisms, enabling spatial orientation, foraging, predator avoidance and social interaction. In species with relatively simple visual systems, such as insects, effective behavioral strategies...
Asymmetry of nucleotide substitutions in tRNAs indicates common descent of modern organisms from a thermophilic ancestor [0.03%]
tRNA中核苷酸替代的非对称性表明现代生物源自嗜热祖先
I I Titov
I I Titov
The nature of the last universal common ancestor (LUCA) of all living organisms remains a controversial issue in biology. There is evidence of both thermophilic and mesophilic LUCA origin. The increasing complexity of the cellular apparatus...