The concept of natural genome reconstruction.Part 6. Analysis of changes in the frequency of occurrence of SNPs in exons of the genes associated with clonal hematopoiesis of uncertain potential in a patient with a neuroendocrine tumor of the small intestine in the terminal stage of progression after modification of the hematopoietic stem cell genome wit [0.03%]
天然基因组重建的概念。第6部分。分析不确定潜能的克隆性造血相关基因外显子中SNPs发生频率的变化：一个小肠神经内分泌肿瘤终末期进展患者经血干细胞基因组修改后的案例
D Y Oshchepkov,V S Ruzanova,S G Oshikhmina et al.
D Y Oshchepkov et al.
The final part of our series of studies reports the results of a pilot study of a clinical case (patient K.), indicating that therapy enabling reconstruction of the genome of hematopoietic stem cells (HSCs) reduces the frequency of SNPs in ...
Selection and evaluation of DNase I hypersensitive sites for prenatal screening of trisomy 21 in the fetus [0.03%]
用于胎儿21三体筛查的DNase I超敏感位点的选择与评估
A M Mazur,A S Starshin,N V Bogush et al.
A M Mazur et al.
This study introduces a novel approach for noninvasive prenatal testing (NIPT) of chromosomal abnormalities, based on analysis of epigenetic features in circulating cell-free DNA (cfDNA). The core innovation of our method leverages fundamen...
Differentiation of subgenomes in StY-genomic species of the genus Elymus (Triticeae, Poaceae) from the territory of Russia according to sequencing data of the nuclear gene GBSS1 (waxy) [0.03%]
俄罗斯苔草属(Elymus)StY基因组物种根据核基因GBSS1(蜡质)测序数据的亚基因组分化分析
A V Agafonov,E V Shabanova Kobozeva,A A Bondar et al.
A V Agafonov et al.
According to the latest data, 55 species of the genus Elymus are distributed in Russia, carrying three subgenomic combinations (StH, StY, and StHY). Among them, the StY-genomic group comprises only 10 species, with varying degrees of unders...
N V Petrash,P I Stepochkin
N V Petrash
Purple-colored grains of cereal crops are characterized by high antioxidant activity. Anthocyanins, polyphenolic compounds found in the pericarp of their grains, have beneficial effects on human health. However, triticale has not yet develo...
Effects of chronic psychosocial stress on the development of mouse oocytes and preimplantation embryos [0.03%]
慢性心理社会压力对小鼠卵母细胞和着床前胚胎发育的影响
T N Igonina,I D Chekashov,A L Levinson et al.
T N Igonina et al.
The impact of psychosocial chronic stress on mammalian oocyte maturation, fertilization and early stages of embryonic development remains poorly understood. This study addresses the effects of chronic psychosocial stress on the reproductive...
Research on genetic diversity and genomes of Miscanthus for optimizing their biotechnological potential [0.03%]
芒草的基因多样性和基因组研究以优化其生物技术潜能
I V Chadaeva,D I Karetnikov,A Yu Pronozin et al.
I V Chadaeva et al.
Plants of the genus Miscanthus are a promising perennial energy crop, combining high biomass productivity, resistance to abiotic stress, and low agricultural technology requirements. This review summarizes recent advances in genomic and tra...
Genetic characterization and meta-analysis of the population of the Northern Black Sea region in the 1st millennium CE based on ancient DNA data [0.03%]
基于古DNA数据的公元前1000年至公元1000年黑海北部地区的人群基因特征及元分析研究
E D Aituganova,A S Kon&#x;kov,T V Andreeva et al.
E D Aituganova et al.
Over the past two decades, the introduction of whole-genome sequencing analysis of ancient DNA has led to a breakthrough in archaeogenetic research, significantly expanding our understanding of human genetic history. In this context the Nor...
A A Sleptcov,M S Nazarenko,V P Puzyrev
A A Sleptcov
The multifactorial etiology of complex diseases involves the interplay of polygenic/oligogenic susceptibility loci and environmental factors. Complex diseases are characterized by pronounced phenotypic variability, genetic heterogeneity, pl...
T N Khamiruev
T N Khamiruev
The sheep was one of the first domesticated animals in Neolithic Southwest Eurasia. The presented study suggests that the domestication of sheep occurred on the Anatolian plateau, to the northwest of the commonly accepted boundaries of the ...
Using genomic screening methods to create high-quality rice breeding material [0.03%]
利用基因组筛选方法创制优质水稻育种材料
N G Tumanyan,Zh M Mukhina
N G Tumanyan
Rice, as a key model in the study of agroecosystem genomics, is the focus of research meant to address the challenges of producing sufficient food for the growing global population. In breeding programs developing new varieties, improving t...