A Shelf Stable Fmoc Hydrazine Resin for the Synthesis of Peptide Hydrazides [0.03%]
用于合成肽肼的稳定Fmoc肼树脂
Michael J Bird,Philip E Dawson
Michael J Bird
C-terminal hydrazides are an important class of synthetic peptides with an ever expanding scope of applications, but their widespread application for chemical protein synthesis has been hampered due to the lack of stable resin linkers for s...
Linearized teixobactin is inactive and after sequence enhancement, kills methicillin-resistant Staphylococcus aureus via a different mechanism [0.03%]
线性化テイクロバチン无活性且序列优化后通过不同机制杀灭耐甲氧西林金黄色葡萄球菌
Qianhui Wu,Biswajit Mishra,Guangshun Wang
Qianhui Wu
Staphylococcus aureus is a highly adaptable pathogen that can rapidly develop resistance to conventional antibiotics such as penicillin. Recently, teixobactin was discovered from uncultivated soil bacteria by using the i-chip technology. Th...
Head-to-tail cyclization of side chain-protected linear peptides to recapitulate genetically-encoded cyclized peptides [0.03%]
通过侧链保护线性肽的头尾环化来重现遗传编码的环化肽
Samir Bouayad-Gervais,Daniel J St-Cyr,Mathieu Courcelles et al.
Samir Bouayad-Gervais et al.
Genetically-encoded cyclic peptide libraries allow rapid in vivo screens for inhibitors of any target protein of interest. In particular, the Split Intein Circular Ligation of Protein and Peptides (SICLOPPS) system exploits spontaneous prot...
Bioactivity improvement via display of the hydrophobic core of HYD1 in a cyclic β-hairpin-like scaffold, MTI-101 [0.03%]
通过在环状β-发卡类似支架MTI-101中展示HYD1的疏水核心来改善生物活性
Priyesh Jain,David B Badger,Yi Liang et al.
Priyesh Jain et al.
HYD1 is an all D-amino acid linear 10-mer peptide that was discovered by one-bead-one-compound screening. HYD1 has five hydrophobic amino acids flanked by polar amino acids. Alanine scanning studies showed that alternating hydrophobic amino...
Computational design of stapled peptide inhibitor against SARS-CoV-2 receptor binding domain [0.03%]
计算设计针对SARS-CoV-2受体结合域的 Stapled Peptide 抑制剂
Asha Rani Choudhury,Atanu Maity,Sayantani Chakraborty et al.
Asha Rani Choudhury et al.
Since its first detection in 2019, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been the cause of millions of deaths worldwide. Despite the development and administration of different vaccines, the situation is still...
Enzymatically Forming Cell Compatible Supramolecular Assemblies of Tryptophan-Rich Short Peptides [0.03%]
富含色氨酸短肽的酶促细胞相容性超分子组装体形成
Dongsik Yang,Beom Jin Kim,Hongjian He et al.
Dongsik Yang et al.
Here we report a new type of tryptophan-rich short peptides, which act as hydrogelators, form supramolecular assemblies via enzymatic dephosphorylation, and exhibit cell compatibility. The facile synthesis of the peptides starts with the pr...
Ayanna Lindsey-Crosthwait,Diana Rodriguez-Lema,Martin Walko et al.
Ayanna Lindsey-Crosthwait et al.
Methods to constrain peptides in a bioactive α-helical conformation for inhibition of protein-protein interactions represent an ongoing area of investigation in chemical biology. Recently, the first example of a reversible "stapling" metho...
Achyut Dahal,Jafrin Jobayer Sonju,Konstantin G Kousoulas et al.
Achyut Dahal et al.
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Covid-19 pandemic has caused high morbidity and mortality rates worldwide. Virus entry into cells can be blocked using several strategies, including inhibition of protein-prot...
Janna N Sloand,Michael A Miller,Scott H Medina
Janna N Sloand
Fluorinated compounds, while rarely used by nature, are emerging as fundamental ingredients in biomedical research, with applications in drug discovery, metabolomics, biospectroscopy, and, as the focus of this review, peptide/protein engine...
The effect of turn residues on the folding and cell-penetrating activity of β-hairpin peptides and applications toward protein delivery [0.03%]
环残留物对β发卡肽折叠及细胞穿膜活性的影响及其在蛋白质传递中的应用
Stephen E Miller,Joel P Schneider
Stephen E Miller
Cell-penetrating peptides (CPPs) are useful tools for the delivery of a wide variety of cargo into cells. Our lab has developed two classes of CPPs based on β-hairpin sequences, one that folds at the surface of cell membranes and the other...