An improved synthesis of Compound 11, a unique bicyclic melanocortin-3 antagonist [0.03%]
化合物11的改进合成方法及其作为独特双环黑色素皮质激素受体3拮抗剂的研究
Stephen T Joy,Naima S Dahir,Roger D Cone et al.
Stephen T Joy et al.
The melanocortin-3 receptor (MC3R) is a G-protein coupled receptor that regulates appetite and is a potential therapeutic target for anorexia and weight loss treatments. The report of a highly selective synthetic antagonist of MC3R, Cpd11, ...
The Role of Structural Flexibility in Hydrocarbon-Stapled Peptides Designed to Block Viral Infection via Human ACE2 Mimicry [0.03%]
基于人类ACE2模拟的抗病毒仿生多肽中构象柔韧性的作用
Sicheng Jiang,Yu Tian,Vlad Nicolaescu et al.
Sicheng Jiang et al.
The COVID-19 pandemic drove a uniquely fervent pursuit to explore the potential of peptide, antibody, protein, and small-molecule based antiviral agents against severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). The interaction b...
Electrostatic origin of a stabilizing synergistic interaction among b-, c-, and f-residues in a trimeric coiled coil [0.03%]
三聚体盘卷螺旋中稳定协同作用的静电起源（B-，C-和F-残基）
Nicholas A Dalley,Kimberlee L Stern,Richard R Kitchen et al.
Nicholas A Dalley et al.
Coiled coils are one of most common protein quaternary structures and represent the best understood relationship between amino acid sequence and protein conformation. Whereas the roles of residues at the canonical heptad positions the a, d,...
Generation and Study of Antibodies against Two Triangular Trimers Derived from Aβ [0.03%]
针对两条三螺旋结构Αβ肽衍生抗原的抗体生成及鉴定研究
Adam G Kreutzer,Ryan J Malonis,Chelsea Marie T Parrocha et al.
Adam G Kreutzer et al.
Monoclonal antibodies (mAbs) that target the P-amyloid peptide (Aβ) are important Alzheimer's disease research tools and are now being used as Alzheimer's disease therapies. Conformation-specific mAbs that target oligomeric and fibrillar A...
Conformationally constrained cyclic grafted peptidomimetics targeting protein-protein interactions [0.03%]
构象受限的环形嫁接肽类似物在针对蛋白质-蛋白质相互作用中的应用
Achyut Dahal,Vivekanandan Subramanian,Prajesh Shrestha et al.
Achyut Dahal et al.
Sunflower trypsin inhibitor-1 (SFTI-1) structure is used for designing grafted peptides as a possible therapeutic agent. The grafted peptide exhibits multiple conformations in solution due to the presence of proline in the structure of the ...
Development of Convergent Hybrid Phase Ligation for Efficient and Convenient Total Synthesis of Proteins [0.03%]
汇聚型杂交相连接子法高效便捷合成蛋白质的研究与发展
Ziyong Z Hong,Ruixuan R Yu,Xiaoyu Zhang et al.
Ziyong Z Hong et al.
Simple and efficient total synthesis of homogeneous and chemically modified protein samples remains a significant challenge. Here, we report development of a convergent hybrid phase native chemical ligation (CHP-NCL) strategy for facile pre...
Targeting Peptide-Based Quorum Sensing Systems for the Treatment of Gram-Positive Bacterial Infections [0.03%]
靶向肽基群体感应系统以治疗革兰氏阳性菌感染
Tahmina A Milly,Yftah Tal-Gan
Tahmina A Milly
Bacteria utilize a cell density-dependent communication system called quorum sensing (QS) to coordinate group behaviors. In Gram-positive bacteria, QS involves the production of and response to auto-inducing peptide (AIP) signaling molecule...
Chemical Shifts of Artificial Monomers Used to Construct Heterogeneous-Backbone Protein Mimetics in Random Coil and Folded States [0.03%]
人工单体的化学位移用于构建无规则卷曲和折叠状态下异背骨多肽模拟物
Shilpa R Rao,Thomas W Harmon,Shelby L Heath et al.
Shilpa R Rao et al.
The construction of protein-sized synthetic chains that blend natural amino acids with artificial monomers to create so-called heterogeneous-backbones is a powerful approach to generate complex folds and functions from bio-inspired agents. ...
Amy H Guadagno,Scott H Medina
Amy H Guadagno
Prion protein misfolding is associated with fatal neurodegenerative disorders such as kuru, Creutzfeldt-Jakob disease, and several animal encephalopathies. While the C-terminal 106-126 peptide has been well studied for its role in prion rep...
Current Peptide Vaccine and Immunotherapy Approaches Against Alzheimer's Disease [0.03%]
针对阿尔茨海默病的当前肽疫苗和免疫治疗策略
Chelsea Marie T Parrocha,James S Nowick
Chelsea Marie T Parrocha
Peptide vaccines and immunotherapies against aggregating proteins involved in the pathogenesis and progression of Alzheimer's disease (AD) - the β-amyloid peptide (Aβ) and tau - are promising therapeutic avenues against AD. Two decades of...