Gene Expression Network Analysis of Precursor Lesions in Familial Pancreatic Cancer [0.03%]
家族性胰腺癌前病变的基因表达网络分析
Ming Tan,Ove B Schaffalitzky de Muckadell,Maiken Thyregod Jøergensen
Ming Tan
Purpose: High-grade pancreatic intraepithelial neoplasia (PanIN) are aggressive premalignant lesions, associated with risk of progression to pancreatic ductal adenocarcinoma (PDAC). A depiction of co-dysregulated gene activity in high-grade...
Subcategorizing T1 Staging in Pancreatic Adenocarcinoma Predicts Survival in Patients Undergoing Resection: An Analysis of the National Cancer Database [0.03%]
胰腺腺癌T1分期的细分可预测接受手术患者的生存率：全国癌症数据库分析
Mihir M Shah,Rachel E NeMoyer,Stephanie H Greco et al.
Mihir M Shah et al.
Purpose: According to the American Joint Committee on Cancer (AJCC) 7th edition, T1 staging of pancreatic adenocarcinoma (PC) is defined as tumor limited to the pancreas, ≤2 cm. The AJCC 8th edition subcategorizes T1 staging into T1a (≤5 ...
The Pathway to Low Outlier Status in Venous Thromboembolism Events: An Analysis of Pancreatic Surgery in the National Surgical Quality Improvement Program [0.03%]
美国外科质量改善项目中胰腺手术后低血栓事件的术前危险因素分析
Samantha L Savitch,Tyler M Bauer,Nkosi H Alvarez et al.
Samantha L Savitch et al.
Purpose: Our institution's hepatopancreaticobiliary surgery service (HPBS) has demonstrated low rates of venous thromboembolism (VTE). We sought to determine whether the HPBS's regimented multimodal VTE prophylaxis pathway, which includes t...
A Phase I Study of Ribociclib Plus Everolimus in Patients with Metastatic Pancreatic Adenocarcinoma Refractory to Chemotherapy [0.03%]
利伯西利联合艾伏免疫素治疗化疗耐药的转移性胰腺癌患者I期临床研究
Benjamin A Weinberg,Hongkun Wang,Agnieszka K Witkiewicz et al.
Benjamin A Weinberg et al.
Purpose: Metastatic pancreatic adenocarcinoma (mPC) has a poor prognosis. CDK4/6 is often deregulated in mPC due to CDKN2A loss, resulting in the loss of p16INK4a that inhibits CDK4/6. CDK4/6 inhibitor monotherapy is ineffective due to RAS-...
Anticancer Effect of New Cannabinoids Derived from Tetrahydrocannabinolic Acid on PANC-1 and AsPC-1 Human Pancreas Tumor Cells [0.03%]
tetrahydrocannabinolic酸衍生物抗癌新 cannabinoids对PANC-1和AsPC-1人胰腺肿瘤细胞的作用
Alexander Aizikovich
Alexander Aizikovich
Purpose: New tetrahydrocannabinolic acid (THCA) derivatives ALAM027 and ALAM108 were proposed for the treatment of the pancreatic cancer disease. Methods: The in vitro effect of new cannabinoids ALAM027 and ALAM108 was tested against PANC-1...
Minimally Invasive Distal Pancreatectomy Is Associated with Decreased Postoperative Neutrophil to Lymphocyte Ratio [0.03%]
微创远端胰腺切除术后中性粒细胞与淋巴细胞比值降低
Richard Zheng,Olivia Wang,Emma Bradley et al.
Richard Zheng et al.
Purpose: The neutrophil-to-lymphocyte ratio (NLR) is a marker of inflammation that has been investigated as a prognostic factor in many diseases. We hypothesized that NLR would be lower in patients undergoing minimally invasive distal pancr...
Safety and Pharmacokinetics of CXCR4 Peptide Antagonist, LY2510924, in Combination with Durvalumab in Advanced Refractory Solid Tumors [0.03%]
针对既往接受过多种治疗的晚期实体瘤患者的CDXCR4肽类拮抗剂LY2510924联合度伐利尤单抗的安全性及药代动力学研究
Mark H O&#x;Hara,Wells Messersmith,Hedy Kindler et al.
Mark H O&#x;Hara et al.
Purpose: This was an open-label phase 1a study assessing the maximum tolerated dose (MTD), safety, and tolerability of CXCR4 peptide antagonist, LY2510924, administered in combination with durvalumab in patients with advanced refractory sol...
Is There a Trojan Horse to Aggressive Pancreatic Cancer Biology? A Review of the Trypsin-PAR2 Axis to Proliferation, Early Invasion, and Metastasis [0.03%]
论胰腺癌生物学中的特洛伊木马吗？关于胰蛋白酶-PAR2轴在增殖、早期浸润和转移中作用的综述
Kjetil Søreide,Marcus Roalsø,Jan Rune Aunan
Kjetil Søreide
Purpose: Pancreatic cancer is one of the most lethal of solid tumors and is associated with aggressive cancer biology. The purpose is to review the role of trypsin and effect on molecular and cellular processes potentially explaining the ag...
Advanced Endoscopic Rescue of a Complication (Duodenojejunostomy Leak) After a Pylorus-Preserving Pancreaticoduodenectomy in a Post-Esophagectomy Patient with Pancreatic Adenocarcinoma: A Case Report and Review of the Literature [0.03%]
保留幽门的胰十二指肠切除术后食管切除患者并发胰腺导管腺癌的内镜处理（十二指肠空肠吻合口漏）：病例报告及文献回顾
Stephanie E Honig,Megan P Lundgren,Thomas E Kowalski et al.
Stephanie E Honig et al.
Background: Approximately 4% of patients develop a second upper gastrointestinal cancer after esophagectomy, and nearly 60,000 people are diagnosed with pancreatic cancer in the United States each year. The need for a Whipple procedure afte...
Pylorus-Preserving Total Pancreatectomy for Intraductal Papillary Mucinous Neoplasm in the Setting of Previous Roux-en-Y Cystjejunostomy for Pancreatic Pseudocyst [0.03%]
既往因胰腺假性囊肿行Roux-en-Y囊空肠吻合术患者中保留幽门的全胰腺切除术治疗黏液性乳头状瘤
Christina M Stuart,Megan P Lundgren,Harish Lavu et al.
Christina M Stuart et al.
Background: Intraductal papillary mucinous neoplasms (IPMNs) are cystic lesions of the pancreas with malignant potential. The Sendai and Fukuoka criteria offer guidelines for surgical management of an IPMN. Presentation: A 69-year-old patie...