"Infiltrative" Versus "Mass-Forming" Pancreatic Cancer: A New Radiological Classification System for Pancreatic Head Ductal Carcinoma and Its Pathological Correlation [0.03%]
浸润型与肿块型胰腺癌：一种新的影像学分类系统及其病理相关性
Muhammad B Darwish,Shankar Logarajah,Patrick J McLaren et al.
Muhammad B Darwish et al.
Purpose: Resectability in localized pancreatic ductal adenocarcinoma (PDAC) is deemed through radiological criteria. Despite initial evaluation classifying tumors as "resectable," they often have ill-defined borders that ...
Qiang Hao,Joel E Segel,Niraj J Gusani et al.
Qiang Hao et al.
Background: The impact of the do-not-resuscitate (DNR) order on patients with pancreatic cancer remains uncertain. In this study, we evaluated whether DNR status was associated with in-hospital mortality and costs for inp...
Integration of Specialized Palliative Care with Oncological Treatment in Patients with Advanced Pancreatic Cancer [0.03%]
专设姑息治疗与晚期胰腺癌患者肿瘤治疗的结合
Anders Ekström,Eva Brun,Jakob Eberhard et al.
Anders Ekström et al.
Introduction: The incidence of pancreatic cancer is around 5 in 100,000, and the 5-year survival is poor. Pancreatic cancer patients have a high disease-specific burden of symptoms, and palliative chemotherapy has varying...
Biliary Leakage Following Pancreatoduodenectomy: Experience from a High-Volume Center [0.03%]
胰头十二指肠切除术后胆漏的一个高容量中心的经验总结
Waqas Farooqui,Luit Penninga,Stefan Kobbelgaard Burgdorf et al.
Waqas Farooqui et al.
Purpose: Hepaticojejunostomy leak and bile fistula after pancreaticoduodenectomy (PD) are less frequent than pancreatic leaks. Patients with biliary fistula (BF) have an increased risk of serious complications and an extended hospital stay....
Isolated Ovarian Metastasis from Pancreatic Cancer Mimicking Primary Ovarian Neoplasia: Role of Molecular Analysis in Determining Diagnosis [0.03%]
胰腺癌卵巢转移瘤模仿原发性卵巢肿瘤的作用分子分析决定诊断
Catherine M Tucker,Cheryl L Godcharles,Wei Jiang et al.
Catherine M Tucker et al.
Background and Presentation: In this study, we present the case of a 64-year-old female with a chief complaint of abdominal pain and bloating, which had been persistent over a period of 4 months. Imaging revealed a 6.1-cm left-sided pancrea...
Sequencing of an Undifferentiated Carcinoma with Osteoclast-Like Giant Cells of the Pancreas: A Case Report [0.03%]
胰腺未分化癌伴巨细胞灶的测序一例报告
Jessica L Smith,Christina L Jacovides,Catherine M Tucker et al.
Jessica L Smith et al.
Background: Undifferentiated carcinoma with osteoclast-like giant cells/osteoclast-like giant cell reaction (UC-OGC) is a rare form of pancreatic cancer historically associated with a poor prognosis. Molecular tumor profiling provides new i...
Cobimetinib Plus Gemcitabine: An Active Combination in KRAS G12R-Mutated Pancreatic Ductal Adenocarcinoma Patients in Previously Treated and Failed Multiple Chemotherapies [0.03%]
康替尼贝联合吉西他滨治疗KRAS G12R突变型胰腺导管腺癌患者（既往多次化疗无效）的一项活性联合疗法
Bach Ardalan,Jose Azqueta,Danny Sleeman
Bach Ardalan
Purpose: The KRAS proto-oncogene is involved in the RAS/MAPK pathway. KRAS is present in the wild type or mutated forms. The oncogene KRAS is frequently mutated in various cancers. At the time that amino acid glycine is mutated, KRAS protei...
A Case Control Study of the Seroprevalence of Helicobacter pylori Proteins and Their Association with Pancreatic Cancer Risk [0.03%]
Hp蛋白质血清学标志物与胰腺癌发病风险的病例对照研究
Jennifer B Permuth,Shams Rahman,Dung-Tsa Chen et al.
Jennifer B Permuth et al.
Background: The association between Helicobacter pylori (H. pylori) infection and pancreatic cancer (PC) risk remains inconclusive. We examined the association between H. pylori antibodies and PC risk in a case-control study at a comprehens...
The Appropriate First-Line Chemotherapy Regimen for Incurable Pancreatic Cancer in Clinical Practice: A Consideration of Patients' Overall Survival and Quality of Life [0.03%]
不可切除胰腺癌患者的一线化疗方案选择——患者生存时间及生活质量的考量
Yasuko Murakawa,Kazunori Ootsuka,Makoto Abue
Yasuko Murakawa
Purpose: For incurable pancreatic cancer, the therapeutic goal is to prolong survival and maintain the quality of life (QOL). Unexpected outpatient consultation (OCT) and emergency hospitalization lead to QOL deterioration. The National Com...
Cholesterol and CDON Regulate Sonic Hedgehog Release from Pancreatic Cancer Cells [0.03%]
胆固醇和CDON调节胰腺癌细胞分泌 sonic hedgehog蛋白
Jennifer I Alexander,Esteban Martinez,Alberto Vargas et al.
Jennifer I Alexander et al.
Background: Sonic Hedgehog (Shh) is a tightly regulated membrane-associated morphogen and a known driver of tumorigenesis in pancreatic ductal adenocarcinoma (PDAC). After processing, Shh remains at the plasma membrane of Shh producing cell...