Glofitamab plus gemcitabine and oxaliplatin for relapsed/refractory DLBCL: 3-year follow-up of STARGLO [0.03%]
关于复发/难治性DLBCL中戈洛塔马布联合吉西他滨和奥沙利铂的3年随访结果：STARGLO研究
Jeremy S Abramson,William Townsend,Christopher P Fox et al.
Jeremy S Abramson et al.
In the phase 3 STARGLO trial (NCT04408638), glofitamab plus gemcitabine-oxaliplatin (Glofit-GemOx) demonstrated superior overall survival (OS) vs rituximab (R)-GemOx, in patients with autologous stem cell transplant (ASCT)-ineligible relaps...
Brentuximab Vedotin after AlloSCT for Relapsed/Refractory Hodgkin Lymphoma: GHSG BV-ALLO Phase II Trial [0.03%]
Brentuximab Vedotin治疗复发及难治性霍奇金淋巴瘤自体移植后的巩固价值：GHSG BV-ALLO二期临床试验
Christof Scheid,Janina Jablonski,Andrea Kerkhoff et al.
Christof Scheid et al.
Inhibition of human FcγRIII prevents platelet destruction in a dual-humanized murine model of FNAIT [0.03%]
抑制人类FcγRIII可预防FNAIT双人源化小鼠模型中的血小板破坏
Zoya Tawhidi,Ulrich J Sachs,Lazaro Gil Gonzalez et al.
Zoya Tawhidi et al.
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) occurs when maternal anti-fetal platelet antibodies, most frequently against HPA-1a, cause fetal platelet destruction. The precise pathogenic mechanisms remain incompletely understood. ...
ZMYM3 mutations modulate histone acetylation and cooperate with NOTCH1 mutations in chronic lymphocytic leukemia [0.03%]
ZMYM3基因突变通过调控组蛋白乙酰化作用并与NOTCH1基因突变协同促进慢性淋巴细胞白血病发生发展
Alberto Rodríguez-Sánchez,Claudia Pérez-Carretero,Luis Antonio Corchete Sanchez et al.
Alberto Rodríguez-Sánchez et al.
ZMYM3 mutations have been recurrently identified in chronic lymphocytic leukemia (CLL) patients at diagnosis. However, their clinical relevance and functional implications remain poorly defined. Here, we comprehensive characterize the clini...
Impact of fludarabine exposure on CAR T-cell outcomes in patients with large B-cell lymphoma [0.03%]
氟达拉滨暴露对大B细胞淋巴瘤患者CAR-T治疗结果的影响
Mario Andrés Sánchez-Salinas,Javier Varela-Gonzalez-Aller,Gloria Iacoboni et al.
Mario Andrés Sánchez-Salinas et al.
The impact of fludarabine pharmacokinetics (PK) on chimeric antigen receptor (CAR) T-cell outcomes is not fully elucidated. We hypothesized that, in relapsed/refractory (R/R) large B-cell lymphoma (LBCL) patients, measured fludarabine expos...
PT/Cy-based alloBMT platform as a curative, accessible alternative for pediatric and young adult severe aplastic anemia [0.03%]
基于同胞供者的清髓性异基因移植平台可作为儿童及年轻成人重型再生障碍性贫血的治愈性且易获得的替代疗法
Margarita Dionysiou,Yiouli P Ktena,Challice L Bonifant et al.
Margarita Dionysiou et al.
Severe aplastic anemia (SAA) is a life-threatening bone marrow failure syndrome. Allogeneic bone marrow transplantation (BMT) is the most definitive curative treatment for SAA and is prioritized when matched sibling donors (MSDs) are availa...
Modulation of the bone marrow microenvironment by acute B-cell lymphoblastic leukemia-derived large oncosomes [0.03%]
急性B细胞急性淋巴细胞白血病来源的大外星体对骨髓微环境的调节作用
Foruzandeh Samangan,Theresa Krack,Fatima Didar Kerman et al.
Foruzandeh Samangan et al.
Within the bone marrow microenvironment, leukemia cells can hijack regulatory intercellular communication routes usually employed by benign hematopoietic cells and establish a microenvironment permissive for (chemo-)therapy-evasive growth. ...
Factors in Implementation of ASH SCD Guidelines on Cognition and Silent Cerebral Infarcts at a Single Sickle Cell Center [0.03%]
单个镰状细胞中心实施ASH SCD指南中关于认知和静默性脑梗死的因素
Jennifer Afranie-Sakyi,Modupe Karimi,Valentina Restrepo et al.
Jennifer Afranie-Sakyi et al.
Peri-transplant molecular MRD monitoring by targeted NGS in patients with FLT3-ITD mutated acute myeloid leukemia [0.03%]
FLT3-ITD基因突变急性髓系白血病患者移植前后的靶向高通量测序MRD监测研究
Xiaoxia Hu,Yeqian Zhao,Chuanhe Jiang et al.
Xiaoxia Hu et al.
Relapse is the predominant cause of treatment failure after allogeneic hematopoietic cell transplantation (allo-HCT) in FLT3-ITD-mutated AML. Although measurable residual disease (MRD) is increasingly used for risk stratification, optimal F...
IMP1 is a novel Post-Transcriptional Regulator of Early Erythroid Development and Embryonic Globin output [0.03%]
IMP1是调控早期红系发育和胚胎血红蛋白表达的新机制
Katherine A MacInnes,Ivan Ferrer-Vicens,Minna Hancock et al.
Katherine A MacInnes et al.
The RNA-binding protein IMP1 is a developmentally expressed, post-transcriptional regulator involved in mRNA stability and translation. In the erythroid lineage, IMP1 was found expressed in fetal, but repressed in adult erythroid cells, bei...