Alterations in the cecal microbiome of New Zealand White rabbits due to the long-acting anticoagulant rodenticide brodifacoum [0.03%]
长效抗凝杀鼠剂溴敌隆对新西兰大白兔结肠微生物组的影响
Ankur Naqib,Intakhar Ahmad,Zachary McDonald et al.
Ankur Naqib et al.
Long-acting anti-coagulant rodenticides (LAARs) are well characterized with respect to inhibition of vitamin K1 synthesis and effects on blood coagulation. However, the effects of LAARs on the microbiome have not been explored. We administe...
Non-adherence with long-term oral vitamin K1 therapy in acute long-acting anticoagulant rodenticides poisoning: A call for action [0.03%]
急性长效抗凝杀鼠药中毒时长期口服维生素K₁治疗不依从：亟待采取行动
Israel Rubinstein,Malvika Kaul,Douglas L Feinstein
Israel Rubinstein
Severe colchicine poisoning treated successfully with kidney replacement therapy and plasmapheresis: a case report [0.03%]
成功采用肾脏替代治疗和血浆置换救治严重秋水仙碱中毒一例报告
D H Schaffer,D L Overbeek,T B Erickson et al.
D H Schaffer et al.
Colchicine is commonly prescribed for treatment of inflammatory conditions but has a narrow therapeutic window and dangerous toxicity profile. Here we describe a case of survival after massive unintentional colchicine overdose treated with ...
Wartime toxicology: the spectre of chemical and radiological warfare in Ukraine [0.03%]
战争毒理学：乌克兰化学和辐射战争的幽灵
P R Chai,Y Berlyand,E Goralnick et al.
P R Chai et al.
The unprovoked invasion of Ukraine by the Russian Federation has resulted in the largest humanitarian crisis in Europe since World War II. As fighting intensifies throughout Ukraine, there is an increasing concern that the Russian Federatio...
Inhaled synthetic cannabinoids laced with long-acting anticoagulant rodenticides: A clear and present worldwide danger [0.03%]
掺有长效抗凝灭鼠剂的合成大麻素吸入剂：一个明显且迫在眉睫的全球性危险
Douglas L Feinstein,John Hafner,Richard van Breemen et al.
Douglas L Feinstein et al.
Macrophage Migration Inhibitory Factor as a Potential Biomarker in Acetaminophen Overdose: A Pilot Study [0.03%]
阿司匹林中毒时巨噬细胞迁移抑制因子作为潜在生物标志物的一项研究
Joshua Bloom,Teddy Uzamere,Yasmin Hurd et al.
Joshua Bloom et al.
Introduction: Acetaminophen overdose is a leading cause of liver failure in the United States. Macrophage migration inhibitory factor (MIF) is a cytokine that is released early and promotes acetaminophen toxicity in precl...
Unmet clinical laboratory need in patients hospitalized for acute poisoning from long-acting anticoagulant rodenticides [0.03%]
长效抗凝杀鼠剂急性中毒住院患者的临床实验室需求未满足情况
Richard B van Breemen,John W Hafner,Daniel G Nosal et al.
Richard B van Breemen et al.
The importance of real-time, quantitative toxicology data available for physicians treating poisoned patients was illustrated during the 2018 outbreak in Illinois of severe coagulopathy caused by inhaling illicit synthetic cannabinoids prod...
Acute Liver Failure of unclear cause? Acetaminophen-protein adducts make the diagnosis [0.03%]
不明原因的急性肝衰竭？ acetaminophen-蛋白加合物明确诊断
Michael E Mullins,Laura P James
Michael E Mullins
Acetaminophen poisoning remains a leading cause of acute liver failure. Some cases may be difficult to diagnose when clinical findings are equivocal, the patient's history is misleading or incomplete, or the acetaminophen concentration is l...
Brodifacoum pharmacokinetics in acute human poisoning: implications for estimating duration of vitamin K therapy [0.03%]
布罗地卡因急性中毒的人体药代动力学情况及维生素K治疗持续时间的估计意义
Daniel G Nosal,Richard B van Breemen,John W Haffner et al.
Daniel G Nosal et al.
Standard of care follow-up therapy for patients poisoned by long-acting anticoagulant rodenticides (LAARs) is daily high-dose (up to 100 mg per day) oral vitamin K1 (VK1) for weeks to months to over a year. The availability of CLIA-certifie...
Care cascade for patients with opioid use disorder and serious injection related infections [0.03%]
阿片类药物使用障碍伴严重注射相关感染患者的治疗链问题
Anand Upadhyaya,Laura R Marks,Evan S Schwarz et al.
Anand Upadhyaya et al.
Objectives: To define the care cascade for patients with serious injection drug use related infections (SIRI) in a tertiary hospital system and compare outcomes of those who did and did not participate in an opioid use di...