Improved segmentation accuracy in high-resolution peripheral quantitative computed tomography scans of carpal bones using adaptive local thresholding [0.03%]
基于自适应局部阈值法的高分辨率周边定量CT掌骨图像分割精度改善方法
Michael T Kuczynski,Simone Poncioni,Sarah Elmahdy et al.
Michael T Kuczynski et al.
The choice of segmentation method for HR-pQCT scans influences accuracy of bone microarchitecture measurements. Smaller or under-mineralized bone can present challenges in accurate extraction of bone structure using global thresholding meth...
Examining the association between sagittal craniosynostosis and midline cephalohematoma [0.03%]
额中线帽状腱膜下血肿与矢状缝早闭关联性的研究
Taylor deVet,Abdulrahman Almansouri,Marco Dallavalle et al.
Taylor deVet et al.
We describe a case with sagittal craniosynostosis accompanied by a midline cephalohematoma. Preoperative CT revealed fusion of the center of the sagittal suture, under the cephalohematoma. Postoperative micro-CT of en bloc specimen confirme...
Case Reports
JBMR plus. 2026 Apr 20;10(6):ziag071. DOI:10.1093/jbmrpl/ziag071 2026
Opportunities for deep learning techniques to advance the histological analysis of preclinical models of osteoarthritis beyond ordinal rank systems [0.03%]
超越序数等级系统的深度学习技术在骨关节炎前期模型组织学分析中的应用机遇
Jacob L Griffith,Yenisel Cruz-Almeida,Alejandro Almarza et al.
Jacob L Griffith et al.
Tools for assessing disease progression are needed to identify and confirm new mechanisms driving osteoarthritis (OA) progression and guide therapeutic development. This review focuses on the advantages and feasibility of leveraging deep le...
An osteoporotic bone model: developing and validating an ex-vivo bone demineralization protocol [0.03%]
骨脱矿化实验模型的建立及验证
Fahad Alabdah,Adel Alshammari,Araida Hidalgo-Bastida et al.
Fahad Alabdah et al.
Studies estimate that there are 500 million osteoporotic patients worldwide. Osteoporosis leads to 2.7 million hip fractures annually. These fractures usually require synthetic implants known as total hip replacement. Orthopedic implant dev...
Spatial transcriptomic profiling of decalcified murine musculoskeletal samples via Xenium Prime 5K [0.03%]
Xenium Prime 5K技术对脱钙小鼠骨肌肉样本的空间转录组分析
Lindsey Lammlin,Huong X Tran,Aanya Mohan et al.
Lindsey Lammlin et al.
Successful generation of high-quality spatial transcriptomics data from murine musculoskeletal tissues has been impeded by the challenge of preserving RNA integrity through the harsh tissue processing steps required for histological section...
Wnt5a gain- and loss-of-function in bone have distinct craniofacial phenotypes [0.03%]
Wnt5a功能获得和丧失导致骨骼具有不同的颅面表型
Claire J Houchen,Portia Hahn Leat,Cassandra Delich et al.
Claire J Houchen et al.
Robinow syndrome has characteristic craniofacial and dental features and can be caused by gain- or loss-of-function variants in Wnt family member 5A (WNT5A) non-canonical signaling. The craniofacial and dental manifestation of Robinow syndr...
Evaluation of the use of segmentation-based and deconvolution-based three-dimensional joint space width analysis of the hand and wrist [0.03%]
基于分割和解卷积的手腕三维关节空间宽度分析的评价研究
Jilmen Quintiens,Tadiwa H Waungana,Michael T Kuczynski et al.
Jilmen Quintiens et al.
Three-dimensional morphometric analyses of joint space from CT scans can provide a quantitative and unbiased evaluation of radiographic damage from arthritis. This potentially offers greater sensitivity for disease assessment and monitoring...
Efficacy, pharmacodynamics, pharmacokinetics, safety, and immunogenicity of Bmab 1000 vs reference denosumab: 78-wk results from a randomized, double-blind, multicenter, parallel-arm Phase 3 trial (DEVOTE) in women with postmenopausal osteoporosis [0.03%]
一项随机双盲多中心平行三期研究（DEVOTE）：Bmab 1000与安加明单抗（Denosumab）对照治疗绝经后骨质疏松女性患者的有效性、药效学、药代动力学、安全性及免疫原性结果（长达78周）
Richard Eastell,Eric Orwoll,Felicia Cosman et al.
Richard Eastell et al.
This randomized, double-blind, multicenter Phase 3 trial evaluated the efficacy, safety, pharmacodynamics (PD), pharmacokinetics (PK), and immunogenicity of Bmab 1000 vs reference denosumab in 479 women with postmenopausal osteoporosis. Par...
Clinical Trial
JBMR plus. 2026 Apr 11;10(6):ziag062. DOI:10.1093/jbmrpl/ziag062 2026
Risk factors for atypical femur fractures with and without bisphosphonate treatment: a national nested case-control study [0.03%]
利塞磷酸钠治疗与非治疗股骨不典型骨折的危险因素研究：一项嵌套病例对照研究
Rasmus Mikiver,Rickard Sand,Hans Peter Bögl et al.
Rasmus Mikiver et al.
Atypical femur fractures (AFF) are rare stress fractures linked to long-term bisphosphonate (BP) use. However, since some patients develop AFF without BP exposure (BP-naïve), additional mechanisms have been proposed. In this study, we test...
Synergistic effects of diabetic neuropathy and kidney function decline on second metatarsal skeletal health and foot function: a pilot study [0.03%]
糖尿病神经病变和肾脏功能下降对跖骨骨骼健康和足部功能的协同影响：一项试点研究
Victor A Cheuy,Saghi Sadoughi,Hasung Moon et al.
Victor A Cheuy et al.
A discouraging increase in diabetes-related nontraumatic lower-extremity amputations (NLEA) has occurred over the last decade. Individuals with diabetic neuropathy (DMPN) and CKD are at the highest risk for NLEA. Despite the critical implic...