Visualization of the hatching of brine shrimp eggs using ultrafast and high-resolution phase-contrast CTs [0.03%]
使用超快速和高分辨率的相位对比CT对盐水虾卵的孵化过程进行可视化展现
Rongbiao Tang,Yanan Fu,Ke Li et al.
Rongbiao Tang et al.
Micro and small organisms (MSOs) are essential components of the ecosystem. Many MSOs reproduce by hatching eggs, making it crucial to study the morphology of these eggs and their incubation products (IPs) in related research. Phase-contras...
PCBP2 promotes immune evasion via cGAS-STING pathway in biochemical recurrence of prostate cancer [0.03%]
PCBP2通过cGAS-STING通路促进前列腺癌生化复发的免疫逃逸
Zeng Zhou,Tiewen Li,Yichen Zhang et al.
Zeng Zhou et al.
Immunotherapy resistance is a significant obstacle in the treatment of prostate cancer (PCa), primarily due to immune evasion mechanisms. This study aims to explore cancer-intrinsic immune evasion-related genes (CIERGs) in PCa and develop a...
Hydrodynamic efficient cell capture and pairing method on microfluidic cell electrofusion chip [0.03%]
微流控细胞电融合芯片上高效细胞捕获及配对方法的液动学研究
Xuefeng Wang,Yaqi Bai,Xiaoling Zhang et al.
Xuefeng Wang et al.
Cell fusion is a widely employed process in various biological procedures, demonstrating significant application value in biotechnology. Cell pairing is a crucial manipulation for cell fusion. Standard fusion techniques, however, often prov...
Epigenetic dynamics in meniscus cell migration and its zonal dependency in response to inflammatory conditions [0.03%]
半月板细胞迁移的表观遗传动力学及其在炎症条件下对区域的依赖性
Yize Zhang,Ellen Y Zhang,Catherine Cheung et al.
Yize Zhang et al.
Meniscus injuries are challenging to treat due to the tissue heterogeneity and limited treatment efficacy. Understanding meniscus cell migration, crucial for healing, remains incomplete, especially its zonal dependency. This study explores ...
Electrospinning strategies targeting fibroblast for wound healing of diabetic foot ulcers [0.03%]
针对糖尿病足溃疡愈合的成纤维细胞电纺策略
Long Chen,Ping Wu,Yu Zhu et al.
Long Chen et al.
The high incidence and prevalence of diabetic foot ulcers (DFUs) present a substantial clinical and economic burden, necessitating innovative therapeutic approaches. Fibroblasts, characterized by their intrinsic cellular plasticity and mult...
Adenine base editing rescues pathogenic phenotypes in tissue engineered vascular model of Hutchinson-Gilford progeria syndrome [0.03%]
腺嘌呤基础编辑挽救了Hutchinson-Gilford早衰综合征组织工程血管模型中的致病表型
Nadia O Abutaleb,Xin D Gao,Akhil Bedapudi et al.
Nadia O Abutaleb et al.
The rare, accelerated aging disease Hutchinson-Gilford Progeria Syndrome (HGPS) is commonly caused by a de novo c.1824 C > T point mutation of the LMNA gene that results in the protein progerin. The primary cause of death is a heart attack ...
Analgesic effect of simultaneously targeting multiple pain processing brain circuits in an aged humanized mouse model of chronic pain by transcranial focused ultrasound [0.03%]
通过经颅聚焦超声同时针对慢性疼痛的老年类人小鼠模型中的多个痛觉处理大脑回路的镇痛效应研究
Min Gon Kim,Chih-Yu Yeh,Kai Yu et al.
Min Gon Kim et al.
Low-intensity transcranial focused ultrasound (tFUS) has recently been shown to noninvasively and non-pharmacologically modulate pain hypersensitivity with high spatial specificity and deep brain penetration. However, the lack of knowledge ...
Polyploidy of MDA-MB-231 cells drives increased extravasation with enhanced cell-matrix adhesion [0.03%]
MDA-MB-231细胞的多倍性导致渗出增加及增强的细胞基质黏附力
Satomi Hirose,Tatsuya Osaki,Roger D Kamm
Satomi Hirose
Metastasis, the leading cause of cancer-related deaths, involves a complex cascade of events, including extravasation. Despite extensive research into metastasis, the mechanisms underlying extravasation remain unclear. Molecular targeted th...
Key influencers in an aneurysmal thrombosis model: A sensitivity analysis and validation study [0.03%]
动脉瘤血栓模型的关键影响因素：敏感性分析和验证研究
Qiongyao Liu,Toni Lassila,Fengming Lin et al.
Qiongyao Liu et al.
Thrombosis is a biological response closely related to intracranial aneurysms, and the formation of thrombi inside the aneurysm is an important determinant of outcome after endovascular therapy. As the regulation of thrombosis is immensely ...
Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations [0.03%]
血管畸形转化的进展中功能失调的机械转导的作用
Wen Yih Aw,Aanya Sawhney,Mitesh Rathod et al.
Wen Yih Aw et al.
Somatic activating mutations in PIK3CA are common drivers of vascular and lymphatic malformations. Despite common biophysical signatures of tissues susceptible to lesion formation, including compliant extracellular matrix and low rates of p...