Degradation-aware neural imputation: Advancing decoding stability in brain machine interfaces [0.03%]
退化感知神经插补：提升脑机接口解码稳定性
Yun-Ting Kuo,Han-Lin Wang,Bo-Wei Chen et al.
Yun-Ting Kuo et al.
Neural signal degradation poses a significant challenge in maintaining stable performance when decoding motor tasks using multiunit activity (MUA) and local field potential (LFP) signals in the implantable brain machine interface (iBMI) app...
Photoplethysmography-based HRV analysis and machine learning for real-time stress quantification in mental health applications [0.03%]
基于PPG的HRV分析和机器学习在心理健康应用中实时量化压力的方法
Ying-Ying Tsai,Yu-Jie Chen,Yen-Feng Lin et al.
Ying-Ying Tsai et al.
Prolonged exposure to high-stress environments can lead to mental illnesses such as anxiety disorders, depression, and posttraumatic stress disorder. Here, a wearable device utilizing photoplethysmography (PPG) technology is developed to no...
Interstitial fluid flow in an engineered human lymph node stroma model modulates T cell egress and stromal change [0.03%]
工程化人类淋巴结基质模型中的间质液流调节T细胞释放和基质变化
Jennifer H Hammel,Abhinav Arneja,Jessica Cunningham et al.
Jennifer H Hammel et al.
The lymph node (LN) performs essential roles in immunosurveillance throughout the body. Developing in vitro models of this key tissue is of great importance to enhancing physiological relevance in immunoengineering. The LN consists of strom...
Predicting the risk of ischemic stroke in patients with atrial fibrillation using heterogeneous drug-protein-disease network-based deep learning [0.03%]
基于异构药物-蛋白质-疾病网络的深度学习预测房颤患者缺血性卒中风险
Zhiheng Lyu,Jiannan Yang,Zhongzhi Xu et al.
Zhiheng Lyu et al.
Current risk assessment models for predicting ischemic stroke (IS) in patients with atrial fibrillation (AF) often fail to account for the effects of medications and the complex interactions between drugs, proteins, and diseases. We develop...
Nugzar Gomidze,Lali Kalandadze,Miranda Khajishvili et al.
Nugzar Gomidze et al.
The present paper explores the application of fluorescence spectroscopy in erythrocyte analysis, aiming to enhance spectral diagnostics in biomedical research. The primary objective is to develop innovative methodologies for improving the p...
Advanced hydrogel mesh platform with neural stem cells and human umbilical vein endothelial cells for enhanced axonal regeneration [0.03%]
一种利用神经干细胞和人脐静脉内皮细胞的水凝胶网架促进轴突再生的新平台技术
Jong-Tae Kim,Sung Woo Han,Dong Hyuk Youn et al.
Jong-Tae Kim et al.
One of the major obstacles to neural recovery following intracerebral hemorrhage (ICH) is the cavity-like lesion that occurs at the site of the hemorrhage, which impedes axonal regeneration. Here, we aim to address this challenge by investi...
Quantitative characterization of the 3D self-organization of PDAC tumor spheroids reveals cell type and matrix dependence through advanced microscopy analysis [0.03%]
PDAC肿瘤类器官的三维自组织的定量特征通过先进的显微镜分析揭示了细胞类型和基质依赖性
Soraya Hernández-Hatibi,Carlos Borau,Neus Martínez-Bosch et al.
Soraya Hernández-Hatibi et al.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant tumor-associated stroma composed from pancreatic stellate cells, which play a critical role in tumor progression. Developing accurate in vitro models requires understan...
Enhanced integrated therapy for breast cancer employing Honokiol-loaded mesoporous polydopamine nanoparticles in conjunction with photothermal effects and low-dose metformin [0.03%]
联合使用雷公藤内酯加载的介孔聚多巴胺纳米颗粒、光热效应及低剂量二甲双胍增强乳腺癌整合治疗效果
Qianqian Du,Qianfan Zhang,Jialing Li et al.
Qianqian Du et al.
Breast cancer remains a significant global health challenge, emphasizing the pressing need for innovative therapeutic approaches. Our thorough research investigates the potential of mesoporous polydopamine nanoparticles (MPDA) as a targeted...
Advances in nanotechnology for targeting cancer-associated fibroblasts: A review of multi-strategy drug delivery and preclinical insights [0.03%]
用于靶向癌症相关纤维细胞的纳米技术进展：多策略药物传输和临床前发现综述
Zhongsong Zhang,Yujie Tang,Dan Luo et al.
Zhongsong Zhang et al.
Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment by promoting tumor growth, immune evasion, and metastasis. Recently, drug delivery systems targeting CAFs have emerged as a promising long-term and effec...
Injectable photosensitive bone cement enhancing angiogenesis and osteogenic differentiation for the treatment of bone nonunion [0.03%]
促进血管生成和成骨分化的可注射光敏骨水泥在治疗骨不连中的应用
Mengnan Wen,Xueqiang Guo,Yan Gong et al.
Mengnan Wen et al.
Nonunion fractures present a significant clinical challenge because of their complex microenvironment, which includes poor vascularization, insufficient osteogenesis, infection, and separation of fracture ends. The current clinical treatmen...