Low-intensity pulsed ultrasound irradiation ameliorates gut inflammation and neuroinflammation in mice with DSS-induced colitis [0.03%]
低强度脉冲超声照射可缓解葡聚糖硫酸钠诱导的小鼠结肠炎肠道和中枢神经系统炎症反应
Shan Tian,Yugang Hu,Yanxiang Zhou et al.
Shan Tian et al.
Ulcerative colitis (UC) is a lifelong autoimmune disease associated with a high prevalence of mental disorders. An abnormal gut-brain axis plays a key role in UC. Low-intensity pulsed ultrasound (LIPUS) has been reported to alleviate neuroi...
Hypoxia-induced RHCG as a key regulator in psoriasis and its modulation by secukinumab [0.03%]
低氧诱导的RHCG在银屑病中的关键调节作用及其与司库奇尤单抗的相互作用
Shun Guo,Qian Zhang,Yuan-Jie Liu et al.
Shun Guo et al.
The interaction between keratinocytes (KCs) and immune cells is essential in the pathogenesis of psoriasis. Understanding this crosstalk is crucial for developing effective treatment strategies. Recent studies indicate that Rh family C-type...
Polarized macrophages modulate cardiac structure and contractility under hypoxia in novel immuno-heart on a chip [0.03%]
新的免疫心脏芯片中缺氧诱导的巨噬细胞极化调节心脏结构和收缩功能
Andrew A Schmidt,Li-Mor David,Nida T Qayyum et al.
Andrew A Schmidt et al.
Cardiac adaptation to hypoxic injury is regulated by dynamic interactions between cardiomyocytes and macrophages, yet the impacts of immune phenotypes on cardiac structure and contractility remain poorly understood. To address this, we deve...
Metronomic photodynamic therapy for deep organ cancer by implantable wireless OLEDs [0.03%]
用于深部器官肿瘤治疗的植入式无线OLED代谢光动力疗法
Yujiro Itazaki,Kei Sakanoue,Katsuhiko Fujita et al.
Yujiro Itazaki et al.
Metronomic photodynamic therapy (mPDT) is a method of continuously delivering low-intensity light to a cancer lesion. This approach does not require high-intensity light, enabling the miniaturization of light devices and making them suitabl...
High-throughput quantitation of human neutrophil recruitment and functional responses in an air-blood barrier array [0.03%]
人中性粒细胞募集和功能反应的高通量定量在空气-血液屏障模型中的研究
Hannah Viola,Liang-Hsin Chen,Seongbin Jo et al.
Hannah Viola et al.
Dysregulated neutrophil recruitment drives many pulmonary diseases, but most preclinical screening methods are unsuited to evaluate pulmonary neutrophilia, limiting progress toward therapeutics. Namely, high-throughput therapeutic assays ty...
Cerebellar contribution to multisensory integration: A computational modeling exploration [0.03%]
小脑在多感觉整合中的作用：一种计算模型研究
Riccardo Cavadini,Luca Casartelli,Alessandra Pedrocchi et al.
Riccardo Cavadini et al.
The remarkable ability of the human brain to create a coherent perception of reality relies heavily on multisensory integration-the complex process of combining inputs from different senses. While this mechanism is fundamental to our unders...
Programmed wound healing in aged skin may be enhanced by mesenchymal cell loaded gene-activated scaffolds [0.03%]
负载间充质细胞的基因激活支架或可增强老化皮肤的程序化伤口愈合
Priya Das,Martin Maresch,Nigamananda Dey et al.
Priya Das et al.
Aging can prolong the wound healing and is associated with decline in stem cells, delays in cellular migration, and lower vascularization. Tissue engineering has largely evolved to incorporate advanced three-dimensional wound dressings, sca...
Hsa_circ_0000467 promotes colorectal cancer proliferation and stem cell characteristics by activating the TCF4/Wnt/β-catenin pathway via sponging miR-520g [0.03%]
Hsa_circ_0000467通过海绵吸附miR-520g激活TCF4/Wnt/β-catenin途径促进结直肠癌的增殖和干细胞特性
Fanggen Xu,Yujing Wang,Rongzhou Liang et al.
Fanggen Xu et al.
This study explores the role of circ_0000467 in colorectal cancer (CRC) progression and its potential as a therapeutic target. Circ_0000467 expression was analyzed using public datasets and clinical samples from 103 CRC patients. Functional...
Post-stroke spontaneous motor recovery in mice can be predicted from acute-phase local field potential using machine learning [0.03%]
机器学习预测小鼠急性期局部场电位介导的卒中后自发性运动恢复
Nicolò Meneghetti,Michael Lassi,Verediana Massa et al.
Nicolò Meneghetti et al.
Stroke remains a leading cause of long-term disability, underscoring the urgent need for effective predictors of motor recovery. Understanding the electrophysiological changes underlying spontaneous recovery could offer critical insight int...
Mechanomemory after short episodes of intermittent stresses induces YAP translocation via increasing F-actin [0.03%]
短期间歇力学刺激诱导的机械记忆通过增加F肌动蛋白促进YAP核转位
Fazlur Rashid,Elvis Njoki,Sadia Amin Kabbo et al.
Fazlur Rashid et al.
How forces and mechanics influence and regulate living cells remains elusive. Mechanomemory, the response to a mechanical perturbation that persists after the perturbation is removed, is believed to be a key to understanding the impact of f...