Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer [0.03%]
ESRP1、HAS2和CD44之间的互连反馈回路调节癌症中的上皮间质可塑性
Mohit Kumar Jolly,Bogdan-Tiberius Preca,Satyendra C Tripathi et al.
Mohit Kumar Jolly et al.
Aberrant activation of epithelial-mesenchymal transition (EMT) in carcinoma cells contributes to increased migration and invasion, metastasis, drug resistance, and tumor-initiating capacity. EMT is not always a binary process; rather, cells...
Breast tumor cell hybrids form spontaneously in vivo and contribute to breast tumor metastases [0.03%]
乳腺肿瘤细胞杂交体在体内自发形成并参与乳腺肿瘤的转移
Casey A Chitwood,Claire Dietzsch,Gabriel Jacobs et al.
Casey A Chitwood et al.
Cancer cell fusion was suggested as a mechanism of metastasis about a century ago. Since then, many additional modes of material transfer (i.e., tunneling nanotubes, and exosomes) to generate cell hybrids have been identified. However, stud...
Epithelial vertex models with active biochemical regulation of contractility can explain organized collective cell motility [0.03%]
活性生化调节收缩性的上皮顶点模型可以解释集体细胞运动的组织性
Sarita Koride,Andrew J Loza,Sean X Sun
Sarita Koride
Collective motions of groups of cells are observed in many biological settings such as embryo development, tissue formation, and cancer metastasis. To effectively model collective cell movement, it is important to incorporate cell specific ...
Joseph P Miller,Brandon H Borde,Francois Bordeleau et al.
Joseph P Miller et al.
Cells receive mechanical cues from their extracellular matrix (ECM), which direct migration, differentiation, apoptosis, and in some cases, the transition to a cancerous phenotype. As a result, there has been significant research to develop...
Perspective: Biophysical regulation of cancerous and normal blood cell lineages in hematopoietic malignancies [0.03%]
论点：血液恶性肿瘤中癌变和正常血细胞谱系的生物物理调控
Sing Wan Wong,Stephen Lenzini,Jae-Won Shin
Sing Wan Wong
It is increasingly appreciated that physical forces play important roles in cancer biology, in terms of progression, invasiveness, and drug resistance. Clinical progress in treating hematological malignancy and in developing cancer immunoth...
Perspective: The role of mechanobiology in the etiology of brain metastasis [0.03%]
展望：机械生物学在脑转移发病机制中的作用
Kandice Tanner
Kandice Tanner
Tumor latency and dormancy are obstacles to effective cancer treatment. In brain metastases, emergence of a lesion can occur at varying intervals from diagnosis and in some cases following successful treatment of the primary tumor. Genetic ...
Review: Mechanotransduction in ovarian cancer: Shearing into the unknown [0.03%]
卵巢癌机械转导研究评论：揭开未知的序幕
Caymen Novak,Eric Horst,Geeta Mehta
Caymen Novak
Ovarian cancer remains a deadly diagnosis with an 85% recurrence rate and a 5-year survival rate of only 46%. The poor outlook of this disease has improved little over the past 50 years owing to the lack of early detection, chemoresistance ...
Adam J Engler,Dennis E Discher
Adam J Engler
The physical and engineering sciences have much to offer in understanding, diagnosing, and even treating cancer. Microfluidics, imaging, materials, and diverse measurement devices are all helping to shift paradigms of tumorigenesis and diss...
Anomalously diffusing and persistently migrating cells in 2D and 3D culture environments [0.03%]
二维和三维培养环境中异常扩散和持续迁移的细胞
Igor D Luzhansky,Alyssa D Schwartz,Joshua D Cohen et al.
Igor D Luzhansky et al.
Appropriately chosen descriptive models of cell migration in biomaterials will allow researchers to characterize and ultimately predict the movement of cells in engineered systems for a variety of applications in tissue engineering. The per...
Probing compression versus stretch activated recruitment of cortical actin and apical junction proteins using mechanical stimulations of suspended doublets [0.03%]
利用机械刺激悬垂双联体的方法研究皮质肌动蛋白和顶小带蛋白的募集倾向于压缩还是拉伸
Xumei Gao,Bipul R Acharya,Wilfried Claude Otto Engl et al.
Xumei Gao et al.
We report an experimental approach to study the mechanosensitivity of cell-cell contact upon mechanical stimulation in suspended cell-doublets. The doublet is placed astride an hourglass aperture, and a hydrodynamic force is selectively exe...