Mechanical features of endothelium regulate cell adhesive molecule-induced calcium response in neutrophils [0.03%]
内皮细胞的机械特性调节中性粒细胞粘附分子诱导的钙反应
Yanhong Xu,Dandan Huang,Shouqin Lü et al.
Yanhong Xu et al.
Atherosclerosis is caused by chronic inflammation associated with the adhesion of neutrophils and endothelial cells (ECs) that is mediated by their respective cellular adhesive molecules to stiffened blood vessel walls. However, the stiffne...
Matrix crosslinking enhances macrophage adhesion, migration, and inflammatory activation [0.03%]
交联细胞外基质蛋白增强巨噬细胞粘附、迁移和炎症反应
Jessica Y Hsieh,Mark T Keating,Tim D Smith et al.
Jessica Y Hsieh et al.
Macrophages are versatile cells of the innate immune system that can adopt a variety of functional phenotypes depending on signals in their environment. In previous work, we found that culture of macrophages on fibrin, the provisional extra...
Modulation of adhesion microenvironment using mesh substrates triggers self-organization and primordial germ cell-like differentiation in mouse ES cells [0.03%]
基于网状底物的黏附微环境调控诱导小鼠ES细胞自我组织及原始生殖细胞样分化
Yuta Ando,Kennedy Omondi Okeyo,Taiji Adachi
Yuta Ando
The cell adhesion microenvironment plays contributory roles in the induction of self-organized tissue formation and differentiation of pluripotent stem cells (PSCs). However, physical factors emanating from the adhesion microenvironment hav...
Tunable synthetic extracellular matrices to investigate breast cancer response to biophysical and biochemical cues [0.03%]
用于研究乳腺癌对生物物理和生物化学刺激反应的可调式合成细胞外基质
Lisa A Sawicki,Elisa M Ovadia,Lina Pradhan et al.
Lisa A Sawicki et al.
The extracellular matrix (ECM) is thought to play a critical role in the progression of breast cancer. In this work, we have designed a photopolymerizable, biomimetic synthetic matrix for the controlled, 3D culture of breast cancer cells an...
Challenges and opportunities in exosome research-Perspectives from biology, engineering, and cancer therapy [0.03%]
外泌体研究的挑战与机遇——来自生物学、工程学和癌症治疗的视角
Xia Li,Alexander L Corbett,Erfan Taatizadeh et al.
Xia Li et al.
Exosomes are small (∼30-140 nm) lipid bilayer-enclosed particles of endosomal origin. They are a subset of extracellular vesicles (EVs) that are secreted by most cell types. There has been growing interest in exosome research in the last d...
Nanostructured carriers as innovative tools for cancer diagnosis and therapy [0.03%]
纳米载体在癌症诊疗中的创新应用
Chiara Martinelli,Carlotta Pucci,Gianni Ciofani
Chiara Martinelli
Cancer accounts for millions of deaths every year and, due to the increase and aging of the world population, the number of new diagnosed cases is continuously rising. Although many progresses in early diagnosis and innovative therapeutic p...
Modeling cardiac complexity: Advancements in myocardial models and analytical techniques for physiological investigation and therapeutic development in vitro [0.03%]
心脏复杂性的建模：用于生理学研究和体外治疗的肌心肌模型和分析技术的发展与应用
Neal I Callaghan,Sina Hadipour-Lakmehsari,Shin-Haw Lee et al.
Neal I Callaghan et al.
Cardiomyopathies, heart failure, and arrhythmias or conduction blockages impact millions of patients worldwide and are associated with marked increases in sudden cardiac death, decline in the quality of life, and the induction of secondary ...
Richard J Mills,James E Hudson
Richard J Mills
Human pluripotent stem cells (hPSCs) have extensive applications in fundamental biology, regenerative medicine, disease modelling, and drug discovery/toxicology. Whilst large numbers of cardiomyocytes can be generated from hPSCs, extensive ...
Extracellular matrix alignment dictates the organization of focal adhesions and directs uniaxial cell migration [0.03%]
细胞外基质排列决定了粘着斑的组织情况并指引单一轴线的细胞迁移
William Y Wang,Alexander T Pearson,Matthew L Kutys et al.
William Y Wang et al.
Physical features of the extracellular matrix (ECM) heavily influence cell migration strategies and efficiency. Migration in and on fibrous ECMs is of significant physiologic importance, but limitations in the ability to experimentally defi...
Early pathological characterization of murine dissecting abdominal aortic aneurysms [0.03%]
小鼠腹主动脉夹层动脉瘤的早期病理特征化
Evan H Phillips,Adam H Lorch,Abigail C Durkes et al.
Evan H Phillips et al.
We report here on the early pathology of a well-established murine model of dissecting abdominal aortic aneurysms (AAAs). Continuous infusion of angiotensin II (AngII) into apolipoprotein E-deficient mice induces the formation of aortic dis...