Transmural remodeling of right ventricular myocardium in response to pulmonary arterial hypertension [0.03%]
肺动脉高压引起右心室肌壁全层重构的反应
Reza Avazmohammadi,Michael Hill,Marc Simon et al.
Reza Avazmohammadi et al.
Pulmonary arterial hypertension (PAH) imposes substantial pressure overload on the right ventricular free wall (RVFW), leading to myofiber hypertrophy and remodeling of its collagen fiber architecture. The transmural nature of these adaptat...
Mathematically universal and biologically consistent astrocytoma genotype encodes for transformation and predicts survival phenotype [0.03%]
数学上通用且生物上一致的星形胶质细胞瘤基因型编码转化并预测生存表型
Katherine A Aiello,Sri Priya Ponnapalli,Orly Alter
Katherine A Aiello
DNA alterations have been observed in astrocytoma for decades. A copy-number genotype predictive of a survival phenotype was only discovered by using the generalized singular value decomposition (GSVD) formulated as a comparative spectral d...
Preserved cardiac function by vinculin enhances glucose oxidation and extends health- and life-span [0.03%]
心肌功能保存剂vinculin增强葡萄糖氧化并延长健康和寿命
Ayla O Sessions,Peter Min,Thekla Cordes et al.
Ayla O Sessions et al.
Despite limited regenerative capacity as we age, cardiomyocytes maintain their function in part through compensatory mechanisms, e.g., Vinculin reinforcement of intercalated discs in aged organisms. This mechanism, which is conserved from f...
Kamyar Esmaeili Pourfarhangi,Edgar Cardenas De La Hoz,Andrew R Cohen et al.
Kamyar Esmaeili Pourfarhangi et al.
Cancer cell migration is essential for metastasis, during which cancer cells move through the tumor and reach the blood vessels. In vivo, cancer cells are exposed to contact guidance and chemotactic cues. Depending on the strength of such c...
A 3D topographical model of parenchymal infiltration and perivascular invasion in glioblastoma [0.03%]
胶质母细胞瘤细胞浸润和血管周围侵袭的三维拓扑模型
Kayla J Wolf,Stacey Lee,Sanjay Kumar
Kayla J Wolf
Glioblastoma (GBM) is the most common and invasive primary brain cancer. GBM tumors are characterized by diffuse infiltration, with tumor cells invading slowly through the hyaluronic acid (HA)-rich parenchyma toward vascular beds and then m...