A human in vitro platform for the evaluation of pharmacology strategies in cardiac ischemia [0.03%]
体外人源平台在心脏缺血药理策略评估中的应用
Carlota Oleaga,Golareh Jalilvand,Gregg Legters et al.
Carlota Oleaga et al.
Cardiac ischemic events increase the risk for arrhythmia, heart attack, heart failure, and death and are the leading mortality condition globally. Reperfusion therapy is the first line of treatment for this condition, and although it signif...
Balance of interstitial flow magnitude and vascular endothelial growth factor concentration modulates three-dimensional microvascular network formation [0.03%]
孔隙流大小和血管内皮生长因子浓度的平衡可调节三维微血管网络形成
Yoshinori Abe,Masafumi Watanabe,Seok Chung et al.
Yoshinori Abe et al.
Hemodynamic and biochemical factors play important roles in critical steps of angiogenesis. In particular, interstitial flow has attracted attention as an important hemodynamic factor controlling the angiogenic process. Here, we applied a w...
Microfluidics-based skin irritation test using in vitro 3D angiogenesis platform [0.03%]
基于微流控的体外三维血管生成皮肤刺激试验
Norhana Jusoh,Jihoon Ko,Noo Li Jeon
Norhana Jusoh
A global ban on animal experiments has been proposed. Hence, it is imperative to develop alternative models. Artificial skin models should reflect the responses of subcutaneous blood vessels and the immune system to elucidate disease and id...
Divide and conquer: A perspective on biochips for single-cell and rare-molecule analysis by next-generation sequencing [0.03%]
分而治之：下一代测序单细胞和罕见分子分析生物芯片透视观点
A C Lee,Y Lee,D Lee et al.
A C Lee et al.
Recent advances in biochip technologies that connect next-generation sequencing (NGS) to real-world problems have facilitated breakthroughs in science and medicine. Because biochip technologies are themselves used in sequencing technologies...
An omentum-inspired 3D PEG hydrogel for identifying ECM-drivers of drug resistant ovarian cancer [0.03%]
受大网膜启发的三维PEG水凝胶在识别药物耐药性卵巢癌的细胞外基质驱动因子中的应用
Elizabeth A Brooks,Maria F Gencoglu,Daniel C Corbett et al.
Elizabeth A Brooks et al.
Ovarian cancer (OvCa) is a challenging disease to treat due to poor screening techniques and late diagnosis. There is an urgent need for additional therapy options, as patients recur in 70% of cases. The limited availability of clinical tre...
Scalable microphysiological system to model three-dimensional blood vessels [0.03%]
一种用于模拟三维血管的可扩展微生理系统
Mees N S de Graaf,Amy Cochrane,Francijna E van den Hil et al.
Mees N S de Graaf et al.
Blood vessel models are increasingly recognized to have value in understanding disease and drug discovery. However, continued improvements are required to more accurately reflect human vessel physiology. Realistic three-dimensional (3D) in ...
Strategies for using mathematical modeling approaches to design and interpret multi-organ microphysiological systems (MPS) [0.03%]
数学建模在多器官微生理系统(MPS)设计和解读中的应用策略分析
Jong Hwan Sung,Ying Wang,Michael L Shuler
Jong Hwan Sung
Recent advances in organ-on-a-chip technology have resulted in numerous examples of microscale systems that faithfully mimic the physiology and pathology of human organs and diseases. The next step in this field, which has already been part...
Oxygen consumption in human, tissue-engineered myobundles during basal and electrical stimulation conditions [0.03%]
静息及电刺激状态下的人体和组织工程化肌束耗氧量研究
Brittany N Davis,Ringo Yen,Varun Prasad et al.
Brittany N Davis et al.
During three-dimensional culture of skeletal muscle in vitro, electrical stimulation provides an important cue to enhance skeletal muscle mimicry of the in vivo structure and function. However, increased respiration can cause oxygen transpo...
Bactericidal activity of 3D-printed hydrogel dressing loaded with gallium maltolate [0.03%]
负载瓜尔胶醇的3D打印载药水凝胶敷料的杀菌活性研究
Stacy Cereceres,Ziyang Lan,Laura Bryan et al.
Stacy Cereceres et al.
Chronic wounds are projected to reach epidemic proportions worldwide because of the aging population and the increasing incidence of diabetes. Despite extensive research, infection remains one of the leading sources of complications in chro...
Elaine J Su,Shaheen Jeeawoody,Amy E Herr
Elaine J Su
Understanding and controlling molecular transport in hydrogel materials is important for biomedical tools, including engineered tissues and drug delivery, as well as life sciences tools for single-cell analysis. Here, we scrutinize the abil...