A rapid method for determining protein diffusion through hydrogels for regenerative medicine applications [0.03%]
用于再生医学应用的蛋白质通过水凝胶扩散的快速测定方法
Marian H Hettiaratchi,Alex Schudel,Tel Rouse et al.
Marian H Hettiaratchi et al.
Hydrogels present versatile platforms for the encapsulation and delivery of proteins and cells for regenerative medicine applications. However, differences in hydrogel cross-linking density, polymer weight content, and affinity for proteins...
Plasma ion implantation enabled bio-functionalization of PEEK improves osteoblastic activity [0.03%]
等离子体离子注入使PEEK生物功能化可改善成骨细胞活性
Edgar A Wakelin,Giselle C Yeo,David R McKenzie et al.
Edgar A Wakelin et al.
Slow appositional growth of bone in vivo is a major problem associated with polyether ether ketone (PEEK) based orthopaedic implants. Early stage promotion of osteoblast activity, particularly bone nodule formation, would help to improve co...
Marcos Latorre,Jay D Humphrey
Marcos Latorre
Most soft biological tissues exhibit a remarkable ability to adapt to sustained changes in mechanical loads. These macroscale adaptations, resulting from mechanobiological cellular responses, are important determinants of physiological beha...
Cell studio: A platform for interactive, 3D graphical simulation of immunological processes [0.03%]
细胞工作室：免疫过程交互式三维图形模拟平台
Asaf Liberman,Danny Kario,Matan Mussel et al.
Asaf Liberman et al.
The field of computer modeling and simulation of biological systems is rapidly advancing, backed by significant progress in the fields of experimentation techniques, computer hardware, and programming software. The result of a simulation ma...
Melina R Megaridis,Yiyang Lu,Erin N Tevonian et al.
Melina R Megaridis et al.
Engineering stochastic fluctuations of gene expression (or "noise") is integral to precisely bias cellular-fate decisions and statistical phenotypes in both single-cell and multi-cellular systems. Epigenetic regulation has been shown to con...
Brock Schuman,Amy Won,Koroboshka Brand-Arzamendi et al.
Brock Schuman et al.
Parkinson's disease neurodegenerative brain tissue exhibits two biophysically distinct α-synuclein fiber isoforms-single stranded fibers that appear to be steric-zippers and double-stranded fibers with an undetermined structure. Herein, we...
Mark P Del Borgo,Ketav Kulkarni,Mary A Tonta et al.
Mark P Del Borgo et al.
Peptides comprised entirely of β3-amino acids, commonly referred to as β-foldamers, have been shown to self-assemble into a range of materials. Previously, β-foldamers have been functionalised via various side chain chemistries to introd...
Porous microspheres support mesenchymal progenitor cell ingrowth and stimulate angiogenesis [0.03%]
多孔微球支持中胚层干细胞生长并刺激血管生成
Thomas E Paterson,Giulia Gigliobianco,Colin Sherborne et al.
Thomas E Paterson et al.
Porous microspheres have the potential for use as injectable bone fillers to obviate the need for open surgery. Successful bone fillers must be able to support vascularisation since tissue engineering scaffolds often cease functioning soon ...
Modelling ischemia-reperfusion injury (IRI) in vitro using metabolically matured induced pluripotent stem cell-derived cardiomyocytes [0.03%]
基于代谢成熟的诱导多能干细胞源性心肌细胞的体外缺血再灌注损伤模型构建
Alejandro Hidalgo,Nick Glass,Dmitry Ovchinnikov et al.
Alejandro Hidalgo et al.
Coronary intervention following ST-segment elevation myocardial infarction (STEMI) is the treatment of choice for reducing cardiomyocyte death but paradoxically leads to reperfusion injury. Pharmacological post-conditioning is an attractive...
Computational study of aortic hemodynamics for patients with an abnormal aortic valve: The importance of secondary flow at the ascending aorta inlet [0.03%]
主动脉瓣异常患者的主动脉血流动力学的数值研究：升主动脉入口处二次流的重要性
S Pirola,O A Jarral,D P O&#x;Regan et al.
S Pirola et al.
Blood flow in the aorta is helical, but most computational studies ignore the presence of secondary flow components at the ascending aorta (AAo) inlet. The aim of this study is to ascertain the importance of inlet boundary conditions (BCs) ...