Emerging mechanomedicines informed by mechanotransduction along the integrin-cytoskeleton-nucleus axis [0.03%]
沿整合素-细胞骨架-细胞核轴力学信号转导的新兴机械药学疗法
Yuka Yokoyama,Nya Domkam,Hannaneh Kabir et al.
Yuka Yokoyama et al.
Mechanical forces are fundamental to the formation of normal biological tissues and the maintenance of physiological health. These forces are transmitted from the extracellular environment to the cell interior through cell-cell and cell-ECM...
Development of large-scale gastruloid array to identify aberrant developmental phenotypes [0.03%]
开发大规模原肠胚样阵列以识别异常的发育表型
Ian Jan,Andrew Cearlock,Min Yang et al.
Ian Jan et al.
Adherent two-dimensional human gastruloids have provided insights into early human embryogenesis. Even though the model system is highly reproducible, no available automated technology can screen and sort large numbers of these near-millime...
Mechanotransduction for therapeutic approaches: Cellular aging and rejuvenation [0.03%]
力学信号转导的治疗作用：细胞衰老与再生
Hye-Min Han,Su-Yeon Kim,Dong-Hwee Kim
Hye-Min Han
Mechanotransduction regulates cytoskeletal remodeling, nuclear mechanics, and metabolic adaptation, which are central to cellular aging and rejuvenation. These responses restore mechanical balance in aged cells, reprogram longevity-related ...
Advanced biomaterial strategies for overcoming age-associated wound healing impairments [0.03%]
高级生物材料策略克服年龄相关伤口愈合障碍
Rodrigo Dores,Telma A Rodrigues,Daniel Carvalho et al.
Rodrigo Dores et al.
Dermal wounds represent a substantial global healthcare burden, with significant economic impact and reduced quality of life for affected individuals. As skin ages, the wound healing capacity is significantly diminished through multiple pat...
Survivin modulates stiffness-induced vascular smooth muscle cell motility [0.03%]
Survivin调控刚度诱导的血管平滑肌细胞运动性
Thomas Mousso,Kalina Rice,Bat-Ider Tumenbayar et al.
Thomas Mousso et al.
Arterial stiffness is a contributor to cardiovascular diseases (CVDs) and is associated with the aberrant migration of vascular smooth muscle cells (VSMCs). However, the mechanisms driving VSMC migration in stiff environments remain unclear...
Identification and regulation of EMT cells in vivo by laser stimulation [0.03%]
通过激光刺激法体内鉴定和调控上皮间质转化细胞
Xiaohui Zhao,Guang Zhu,Meng Xue et al.
Xiaohui Zhao et al.
Cells undergoing epithelial-to-mesenchymal transition (EMT) exhibit significant plasticity, making them more tumorigenic, invasive, and stem-like. PLCG2 has been identified as being linked to EMT. Specifically, the PLCG2-high subpopulation ...
Guest Editorial: Structure and mechanics of biofluids, biomaterials, and biologics [0.03%]
客编专文：生物流体、生物材料和生物药物的结构与力学
E M Furst,F Scheffold,G H McKinley
E M Furst
Franklin Leong,Silvestro Micera,Solaiman Shokur
Franklin Leong
Restoring natural sensation via neuroprosthetics relies on the possibility of encoding complex and nuanced information. For example, an ideal brain-machine interface with sensory feedback would provide the user with sensation about movement...
Liquid metal-based stretchable bioelectronic fiber for electrical stimulation and drug delivery in minimally invasive cardiac therapy [0.03%]
用于微创心脏治疗的液态金属可拉伸生物电子纤维电刺激和药物输送
Chanhui Park,Yesol Kim,Seonghyeon Nam et al.
Chanhui Park et al.
Cardiovascular diseases, such as ventricular arrhythmias and heart failure, require timely and effective treatment to prevent disease progression and improve patient outcomes. Current therapeutics, including electrical shock and emergent ca...
Classification of differentially activated groups of fibroblasts using morphodynamic and motile features [0.03%]
基于形态动力学和运动特征的成纤维细胞亚群分类
Minwoo Kang,Chanhong Min,Somayadineshraj Devarasou et al.
Minwoo Kang et al.
Fibroblasts play essential roles in cancer progression, exhibiting activation states that can either promote or inhibit tumor growth. Understanding these differential activation states is critical for targeting the tumor microenvironment (T...