Development of low-cost electrical stimulation device to promote hiPSC-CM differentiation and functionality [0.03%]
低成本电刺激设备的开发以促进hiPSC-CM分化和功能成熟
Nikhith Kalkunte,Sogu Sohn,Cody Callahan et al.
Nikhith Kalkunte et al.
Human induced pluripotent stem cell differentiated cardiomyocytes (hiPSC-CMs) hold great potential to resolve cardiovascular disease but are stymied by their functional immaturity. The complex electric potentials measured during cardiogenes...
Formononetin suppresses osteosarcoma by targeting MYO1B and remodeling the tumor immune microenvironment [0.03%]
_frmother：弗蒙酮通过靶向MYO1B和重塑肿瘤免疫微环境抑制骨肉瘤
Yun Liu,Liang Xiong,Wenyu Feng et al.
Yun Liu et al.
Resistance to and associated toxic side effects of neoadjuvant chemotherapy remain major obstacles to improving the prognosis of osteosarcoma patients. Consequently, there is an urgent need to discover effective therapeutic agents with lowe...
Prediction of chronic obstructive pulmonary disease based on multimodal data and deep learning [0.03%]
基于多模态数据和深度学习的慢性阻塞性肺疾病预测
Haoran Deng,Xuchun Ding,Shiping Zhu et al.
Haoran Deng et al.
To address the issues of insufficient utilization of multimodal information, modal heterogeneity, and data gaps leading to poor model generalization in early prediction of chronic obstructive pulmonary disease (COPD), a deep learning-based ...
Stiffness-mediated paracrine signaling enhances induction of EMT in oral squamous cell carcinoma [0.03%]
刚度介导的旁分泌信号增强口腔鳞状细胞癌中上皮间质转化的诱导作用
So Youn Moon,Marcelo Lazzaron Lamers,Adam J Engler
So Youn Moon
Oral Squamous Cell Carcinoma (OSCC) contains diverse communities of cells within the oral mucosa. A subset of the epithelia is highly responsive to changing niche conditions, resulting in their loss of polarity, epithelial-to-mesenchymal tr...
Cell-mediated matrix deformations and cell-cell adhesions determine epithelial collective cell migration phenotypes [0.03%]
细胞介导的基质变形和细胞间粘附决定了上皮集体细胞迁移表型
Corinne E Leonard,Jessanne Y Lichtenberg,Hazel R Sterling et al.
Corinne E Leonard et al.
Successful development of tissue structures requires different collective cell migration patterns or phenotypes. Two examples of collective migration phenotypes in epithelial morphogenic processes, such as tubulogenesis, are rotational and ...
Tissue regenerative medicine: Clinical advances, challenges, and opportunities [0.03%]
组织再生医学：临床进展、挑战与机遇
Seleem Badawy,Varshiny Gopinath,Ana M Diaz Espinosa et al.
Seleem Badawy et al.
Regenerative medicine is transforming how we restore tissue function, leveraging advances in cell and molecular biology, biomaterials, and engineered microenvironments. While there have been notable advances and rapid progress over the past...
Microfluidic lung cancer models: Bridging clinical treatment strategies and tumor microenvironment recapitulation [0.03%]
微流控肺癌模型：临床治疗策略与肿瘤微环境再现之间的桥梁关系
Zhiyun Yu,Arsalan A Khan,Wara Naeem et al.
Zhiyun Yu et al.
Lung cancer remains the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer accounting for a majority of cases. Despite advances in targeted therapies and immunotherapy, challenges such as tumor heterogeneit...
Integration of single-cell and bulk transcriptomics uncovers CHST6 as a shared pathogenic driver in idiopathic pulmonary fibrosis and lung cancer [0.03%]
单细胞和大队列转录组数据整合分析发现CHST6基因在特发性肺纤维化和肺癌中具有共同致病作用
Shengqiang Mao,Jiayi Jiang,Zhiqiang Liu et al.
Shengqiang Mao et al.
Idiopathic pulmonary fibrosis (IPF), a progressive and fatal lung disease, significantly increases the risk of lung cancer, particularly lung adenocarcinoma (LUAD). However, the shared genetic mechanisms driving IPF and LUAD comorbidities r...
Mechanomedicine: Translating mechanical forces into therapeutic strategies [0.03%]
力学生物学：将机械力转化为治疗策略
Geraldine M O&#x;Neill,Cheng Zhu,Dong-Hwee Kim et al.
Geraldine M O&#x;Neill et al.
Mechanomedicine is an emerging interdisciplinary field that applies the principles of mechanobiology to understand, diagnose, and treat disease. Recent advances reveal how mechanical cues such as stiffness, flow, and compression shape cell ...
Linlin Li,David Gazzo,Shams Mowafak Saad et al.
Linlin Li et al.
Living systems process a broad range of internal and external stimuli, respond to environmental constraints, and adapt to various conditions through tight coordination between signaling networks and cellular mechanics. Among these, calcium ...