An organic neurophysiological tool for neuronal metabolic activity monitoring [0.03%]
一种用于监测神经元代谢活动的有机神经生理工具
A Spanu,M T Tedesco,L Martines et al.
A Spanu et al.
Monitoring cell metabolism in vitro is considered a relevant methodology in several scientific fields ranging from fundamental biology research to neuro-toxicology. In the last 20 years, several in vitro neuro-pharmacological and neuro-toxi...
FGF-2 inhibits contractile properties of valvular interstitial cell myofibroblasts encapsulated in 3D MMP-degradable hydrogels [0.03%]
FGF-2通过三维基质金属蛋白酶可降解水凝胶抑制瓣膜间充质干细胞来源肌成纤维细胞的收缩性质
Andrea Gonzalez Rodriguez,Megan E Schroeder,Cierra J Walker et al.
Andrea Gonzalez Rodriguez et al.
Valvular interstitial cells (VICs) are responsible for the maintenance of the extracellular matrix in heart valve leaflets and, in response to injury, activate from a quiescent fibroblast to a wound healing myofibroblast phenotype. Under no...
Identification of on-target mutagenesis during correction of a beta-thalassemia splice mutation in iPS cells with optimised CRISPR/Cas9-double nickase reveals potential safety concerns [0.03%]
优化CRISPR/Cas9双切核酸酶矫正IPS细胞中β-地中海贫血剪接突变的靶点突变鉴定结果表明潜在的安全隐患
Suad Alateeq,Dmitry Ovchinnikov,Timothy Tracey et al.
Suad Alateeq et al.
Precise and accurate gene correction is crucial for enabling iPSC-based therapies, and Cas9-Nickase based approaches are increasingly considered for in vivo correction of diseases such as beta-thalassemia. Here, we generate footprint-free i...
A microscale biomimetic platform for generation and electro-mechanical stimulation of 3D cardiac microtissues [0.03%]
一种微型仿生平台用于三维心脏微组织的生成及机电刺激
Roberta Visone,Giuseppe Talò,Paola Occhetta et al.
Roberta Visone et al.
Organs-on-chip technology has recently emerged as a promising tool to generate advanced cardiac tissue in vitro models, by recapitulating key physiological cues of the native myocardium. Biochemical, mechanical, and electrical stimuli have ...
Nonlinear electrocardiographic imaging using polynomial approximation networks [0.03%]
基于多项式逼近网络的心电非线性逆向成像方法研究
Abhejit Rajagopal,Vincent Radzicki,Hua Lee et al.
Abhejit Rajagopal et al.
Electrocardiography is a valuable tool to aid in medical understanding and treatment of heart-related ailments, specifically atrial fibrillation (AF) and other irregular cardiac behavior. Although signs of AF will manifest in conventional e...
Review: Synthetic scaffolds to control the biochemical, mechanical, and geometrical environment of stem cell-derived brain organoids [0.03%]
基于干细胞的类脑器官合成支架的研究进展：控制生化、力学及几何微环境
Mariana Oksdath,Sally L Perrin,Cedric Bardy et al.
Mariana Oksdath et al.
Stem cell-derived brain organoids provide a powerful platform for systematic studies of tissue functional architecture and the development of personalized therapies. Here, we review key advances at the interface of soft matter and stem cell...
Roger D Kamm,Rashid Bashir,Natasha Arora et al.
Roger D Kamm et al.
Recent technological breakthroughs in our ability to derive and differentiate induced pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all contributed to a heightened interest in the design, assembly,...
Fibroblast migration correlates with matrix softness. A study in knob-hole engineered fibrin [0.03%]
纤维软骨关联成纤维细胞迁移。嵌入 fibrin 的凸起-空洞结构的研究
Christopher Y Leon-Valdivieso,Jennifer Wedgwood,Enrique Lallana et al.
Christopher Y Leon-Valdivieso et al.
The invasion of a matrix by migrating cells is a key step in its remodelling. At least in 2D migration models, cells tend to localize in stiffer areas (durotaxis). Here, we show that mechanical properties affect differently the 3D migration...
Shamim M Ahmmed,Swastika S Bithi,Adity A Pore et al.
Shamim M Ahmmed et al.
There is growing recognition that cell deformability can play an important role in cancer metastasis and diagnostics. Advancement of methods to characterize cell deformability in a high throughput manner and the capacity to process numerous...
The effect of mechanosensitive channel MscL expression in cancer cells on 3D confined migration [0.03%]
机械敏感通道MscL在癌细胞中表达对三维受限迁移的影响研究
Johanna Heureaux-Torres,Kathryn E Luker,Henry Haley et al.
Johanna Heureaux-Torres et al.
Metastatic cancer cells migrate through constricted spaces and experience significant compressive stress, but mechanisms enabling migration in confined geometries remain unclear. Cancer cell migration within confined 3-dimensional (3D) micr...