Microphysiological systems modeling acute respiratory distress syndrome that capture mechanical force-induced injury-inflammation-repair [0.03%]
用于模拟急性呼吸窘迫综合征的微生理系统模型可捕捉机械力引起的损伤-炎症-修复作用
Hannah Viola,Jonathan Chang,Jocelyn R Grunwell et al.
Hannah Viola et al.
Complex in vitro models of the tissue microenvironment, termed microphysiological systems, have enormous potential to transform the process of discovering drugs and disease mechanisms. Such a paradigm shift is urgently needed in acute respi...
Dongjune Kim,Christopher Bresette,Zixiang Liu et al.
Dongjune Kim et al.
Thrombus formation in major arteries is life threatening. In this review article, we discuss how an arterial thrombus can form under pathologically high shear stresses, with bonding rates estimated to be the fastest K o n values in bioch...
Microfiber-shaped building-block tissues with endothelial networks for constructing macroscopic tissue assembly [0.03%]
具有内皮网络的微纤维构建块组织，用于组装宏观尺度的人造组织复合体
Yuta Kurashina,Ryo Sato,Hiroaki Onoe
Yuta Kurashina
We describe a microfiber-shaped hepatic tissue for in vitro macroscopic tissue assembly, fabricated using a double coaxial microfluidic device and composed of cocultured Hep-G2 cells and human umbilical vein endothelial cells (HUVECs). The ...
Disease-directed engineering for physiology-driven treatment interventions in neurological disorders [0.03%]
生理驱动的治疗干预在神经性疾病中的定向工程疗法
Thomas Wood,Elizabeth Nance
Thomas Wood
Neurological disease is killing us. While there have long been attempts to develop therapies for both acute and chronic neurological diseases, no current treatments are curative. Additionally, therapeutic development for neurological diseas...
Microphysiological systems [0.03%]
微生理系统
James J Hickman,Dongeun Huh,Roger D Kamm
James J Hickman
The rationale and emergence of electroconductive biomaterial scaffolds in cardiac tissue engineering [0.03%]
心脏组织工程中导电生物材料支架的由来及发展状况综述
Matteo Solazzo,Fergal J O&#x;Brien,Valeria Nicolosi et al.
Matteo Solazzo et al.
The human heart possesses minimal regenerative potential, which can often lead to chronic heart failure following myocardial infarction. Despite the successes of assistive support devices and pharmacological therapies, only a whole heart tr...
Varying solvent type modulates collagen coating and stem cell mechanotransduction on hydrogel substrates [0.03%]
溶剂类型变化调节水凝胶基质上的胶原包被和干细胞力学生物效应
Alice E Stanton,Xinming Tong,Fan Yang
Alice E Stanton
Type I collagen is the most abundant extracellular matrix protein in the human body and is commonly used as a biochemical ligand for hydrogel substrates to support cell adhesion in mechanotransduction studies. Previous protocols for conjuga...
Magnetic localization and control of helical robots for clearing superficial blood clots [0.03%]
用于清除浅表性血栓的螺旋机器人的磁定位与控制
Islam S M Khalil,Alaa Adel,Dalia Mahdy et al.
Islam S M Khalil et al.
This work presents an approach for the localization and control of helical robots during removal of superficial blood clots inside in vitro and ex vivo models. The position of the helical robot is estimated using an array of Hall-effect sen...
Automated sensing and splitting of stem cell colonies on microraft arrays [0.03%]
微载体阵列中干细胞菌落的自动感应与分割技术
Matthew DiSalvo,Nicole M Smiddy,Nancy L Allbritton
Matthew DiSalvo
Human induced pluripotent stem cells (hiPSCs) are widely used for disease modeling, tissue engineering, and clinical applications. Although the development of new disease-relevant or customized hiPSC lines is of high importance, current aut...
GSVD- and tensor GSVD-uncovered patterns of DNA copy-number alterations predict adenocarcinomas survival in general and in response to platinum [0.03%]
基于GSVD和张量GSVD的DNA拷贝数改变模式可预测腺癌总体生存率及对铂类药物的反应
Matthew W Bradley,Katherine A Aiello,Sri Priya Ponnapalli et al.
Matthew W Bradley et al.
More than a quarter of lung, uterine, and ovarian adenocarcinoma (LUAD, USEC, and OV) tumors are resistant to platinum drugs. Only recently and only in OV, patterns of copy-number alterations that predict survival in response to platinum we...