Mechanical cues orchestrate monocyte behavior in immune regulation and disease [0.03%]
机械刺激在免疫调控和疾病中的单核细胞行为引导作用
Yifan Lin,Hardik Makkar,Shuchen Zhang et al.
Yifan Lin et al.
Monocytes, key mediators of innate immunity, exhibit remarkable sensitivity to mechanical cues such as extracellular matrix (ECM) stiffness, substrate rigidity, shear stress, compression, and hydrostatic pressure, which shape their activati...
Recent advancements in polymer science for retinal diseases: New frontiers in drug delivery systems [0.03%]
近年聚合物科学在视网膜疾病治疗中的进展：药物输送系统的新的前沿领域
Weiliang Wang,Nancy Wang,Xinxin Zhao et al.
Weiliang Wang et al.
Retinal diseases, such as age-related macular degeneration and diabetic macular edema, are significant contributors to vision loss. While injection of anti-vascular endothelial growth factors is the current gold standard treatment, their in...
Epigenetic regulation and mechanobiological adaptation in tenocytes during maturation [0.03%]
肌腱细胞成熟过程中的表观遗传调控与机械生物学适应性
Ellen Y Zhang,Tyler E Blanch,Saeed B Ahmed et al.
Ellen Y Zhang et al.
Tendons are essential for musculoskeletal function, facilitating movement by transmitting forces from muscles to bones. However, aging alters the tendon microenvironment, disrupting the delicate interactions between tenocytes and the extrac...
Yeji Chang,Jia Wen Nicole Lee,Andrew W Holle
Yeji Chang
Fibroblasts play crucial roles in wound healing, cancer, and fibrosis. Many aspects of these roles are driven by the process known as fibroblast activation. The generally accepted definition of fibroblast activation is the transition from a...
Astrocyte-driven vasoconstriction impairs glymphatic clearance in a human tauopathy-on-chip model [0.03%]
astrocyte驱动的血管收缩损害了人类tau病芯片模型中的glymphatic清除功能
Rena Park,Yansong Peng,Aria R Yslas et al.
Rena Park et al.
The glymphatic system is a critical pathway for clearing metabolic waste from the brain by mediating cerebrospinal fluid and interstitial fluid exchange. In Alzheimer's disease (AD), tau protein accumulation is strongly associated with impa...
Modeling nitric oxide diffusion and plasticity modulation in cerebellar learning [0.03%]
硝酸盐扩散和塑形调节在小脑学习中的作用模型
Alessandra Maria Trapani,Carlo Andrea Sartori,Benedetta Gambosi et al.
Alessandra Maria Trapani et al.
Nitric oxide (NO) is a versatile signaling molecule with significant roles in various physiological processes, including synaptic plasticity and memory formation. In the cerebellum, NO is produced by neural NO synthase and diffuses to influ...
Application of instant assembly of collagen to bioprint cardiac tissues [0.03%]
基于即刻组装胶原的生物打印心脏组织的研究
Hugh Xiao,Zixie Liang,Xiangyu Gong et al.
Hugh Xiao et al.
Advancing cardiac tissue engineering requires innovative fabrication techniques, including 3D bioprinting and tissue maturation, to enable the generation of new muscle for repairing or replacing damaged heart tissue. Recent advances in tiss...
Decoding force-transmission linkages for therapeutic targeting and engineering [0.03%]
用于治疗和工程设计的力传导链解析
Jingzhun Liu,Yunxin Deng,Jie Yan
Jingzhun Liu
Mechanosensing and mechanotransduction enable cells to perceive and respond to mechanical forces, underpinning essential physiological processes and disease pathways. Central to these phenomena are force-transmission supramolecular linkages...
Evaluation of screw pull-out from plate fixation of en bloc distal radius resection with ulnar reconstruction: Finite element analysis and comparison with experiments on Thiel cadavers [0.03%]
评估尺骨重建远端桡骨整块切除术中接骨板固定螺钉拔出的有限元分析及与Thiel尸体实验对比研究
Wares Chancharoen,Theingi Nwe,Saran Seehanam et al.
Wares Chancharoen et al.
Fractures of the distal radius often require surgical intervention, with plate fixation being a standard stabilization method. Screw loosening and pull-out propose significant complications, necessitating comprehensive understanding of fixa...
Pulsatile low shear stress increases susceptibility to endothelial inflammation via upregulation of IFT and activation of YAP [0.03%]
脉动低切应力通过上调内皮细胞逆向转运和活化YAP增加内皮炎症的敏感性
Yu Hou,Hazel R C Screen,Martin M Knight
Yu Hou
This study describes the development of a microfluidic chip model of the coronary artery endothelium and its use to examine the mechanism through which pulsatile shear stress regulates inflammation. The chip successfully recapitulates incre...