Mesenchymal stem cell membrane-coated kaempferol biomimetic nanoformulation for the treatment of atherosclerosis [0.03%]
用于治疗动脉粥样硬化的黄酮醇仿生纳米制剂的间充质干细胞膜涂层技术
Qianting Zhang,Xiangxiu Wang,Hongping Zhang et al.
Qianting Zhang et al.
Atherosclerosis and its complications are highly prevalent worldwide, and managing oxidative stress in endothelial cells to alleviate abnormal inflammatory damage is a critical therapeutic approach. Nanomedicine delivery systems offer promi...
Biobased adhesive hydrogels for wound management and tissue repair: From materials to advanced applications [0.03%]
基于生物的伤口管理及组织修复粘合水凝胶材料：从材料到先进应用
Dongyang Miao,Yige Gao,Bowen Shi et al.
Dongyang Miao et al.
Effective tissue adhesion under wet and dynamic physiological conditions remains a major challenge in wound management and tissue repair. Conventional tissue adhesives often suffer from limited biocompatibility, inadequate wet adhesion, or ...
Cell shape and maturation impacts α-actinin-2 tension in iPSC-derived cardiomyocytes [0.03%]
细胞形状和成熟对诱导多能干细胞源性心肌细胞α-actinin-2张力的影响
Palash K Dutta,Joshua M Toth,Subramanian Sundaram et al.
Palash K Dutta et al.
The contractile activity of cardiomyocytes (CMs) critical to heart function emerges from the collective shortening of sarcomeres. However, how these sarcomeric forces are transmitted within CMs during this process remains poorly understood....
Enhancing upper limb motor recovery prediction after acute stroke using EEG and subacute data [0.03%]
结合脑电图和亚急性期数据提高对急性卒中后上肢运动恢复的预测能力
Michael Lassi,Stefania Dalise,Luigi Privitera et al.
Michael Lassi et al.
Electroencephalography (EEG) has shown promise in assessing and monitoring functional recovery in stroke survivors, but its utility in predicting upper limb motor recovery in a data-driven framework remains underexplored. This study present...
Multi-omics mapping identifies CYBA-mediated mitochondrial dysfunction driving macrophage polarization and ferroptosis via Nrf2 pathway in atherosclerosis [0.03%]
多组学分析揭示CYBA介导的线粒体功能障碍通过Nrf2通路驱动动脉粥样硬化巨噬细胞极化和铁死亡
Chen Dong,Rui Shen,Chengliang Pan et al.
Chen Dong et al.
Atherosclerosis (AS), a chronic inflammatory process driven largely by macrophage-mediated plaque formation, remains poorly understood in mitochondrial-macrophage crosstalk. While CYBA polymorphisms correlate with cardiovascular risk, the f...
Synthetic mucus biomaterials enable localized therapeutic antibody delivery in inflammatory bowel disease [0.03%]
合成黏液生物材料能够用于炎症性肠病的局部治疗抗体递送
Taj Yeruva,Sydney Yang,Michele Kaluzienski et al.
Taj Yeruva et al.
Inflammatory bowel disease (IBD) is a chronic condition characterized by recurrent gastrointestinal inflammation that requires long-term therapeutic intervention. While anti-TNF-α monoclonal antibodies (mAbs) are effective in maintaining r...
Decoding lower-limb movement attempts from electro-encephalographic signals in spinal cord injury patients [0.03%]
从脊髓损伤患者的脑电图信号中解码下肢运动意图
Laura Toni,Valeria De Seta,Luigi Albano et al.
Laura Toni et al.
Restoring lower-limb function in patients with severe spinal cord injury (SCI) remains challenging. Spinal cord stimulation may enhance and reinstate lower-limb movements, but it is either used in open-loop control or its control depends up...
Region-dependent mechanical parameters in simulating cerebral atrophy [0.03%]
基于区域的脑皮层萎缩有限元模型参数确定方法研究
Nicole Tueni,Emma Griffiths,Johannes Weickenmeier et al.
Nicole Tueni et al.
Brain aging and atrophy involve complex multiscale factors of cellular degeneration and morphological changes. Although previous biomechanical models have advanced our understanding of brain shrinkage due to physiological and pathological a...
Trans-septal delivery of hydrogel-encapsulated human umbilical cord MSC-derived neurospheres for acute neuroprotection in traumatic brain injury [0.03%]
人脐带间充质干细胞来源的神经球载药水凝胶穿过房间隔给药治疗创伤性脑损伤
Dong Wook Kim,Ok Joo Lee,Bo Young Choi et al.
Dong Wook Kim et al.
This study explores the therapeutic potential of hydrogel-encapsulated neurospheres derived from human umbilical cord mesenchymal stem cells (hUC-MSCs) in mitigating traumatic brain injury (TBI) and enhancing functional recovery in a rodent...
Integrating Mendelian randomization and multi-omics analysis unravels gut microbiota-driven metabolic mechanisms in sepsis and identifies diagnostic biomarkers through experimental validation [0.03%]
结合孟德尔随机化和多组学分析解开了肠道微生物驱动的脓毒症代谢机制，并通过实验验证识别出诊断生物标志物
Guangyao Wang,Yuanyuan Liu,Jinjing Tan et al.
Guangyao Wang et al.
Sepsis, a life-threatening systemic inflammatory syndrome, remains a leading cause of global mortality due to its complex pathophysiology and the lack of specific diagnostic biomarkers. Recent evidence highlights intricate interactions betw...