Selective capture and digital counting of intact HIV pseudovirus using designer DNA nets, tethered motion, and photonic resonator interferometric scattering microscopy [0.03%]
利用设计DNA网、受控运动和光子共振散射干涉显微镜完整捕获并计数HIV假病毒
Joseph Tibbs,Saurabh Umrao,Tingjie Song et al.
Joseph Tibbs et al.
Rapid and quantitatively accurate detection of HIV (human immunodeficiency virus) viral load using a simple workflow, automated instrumentation, and real-time data processing with easily interpretable output is required for an approach to b...
Chengliang Yin,Xiaochun Sun,Anlin Dai et al.
Chengliang Yin et al.
The integration of artificial intelligence, notably the generative language model ChatGPT, into precision medicine precedes a paradigm shift in healthcare. This Review explores the capabilities of ChatGPT to process large data sets, underst...
Closing the loop on glioblastoma: A roadmap toward developing bioelectronics for continuous monitoring of tumor state [0.03%]
胶质母细胞瘤的闭环调控：开发用于连续监测肿瘤状态的生物电子学路线图
Ester Clarisse do Couto Lopes,Joshua P A Daoud,Alexandra Collisson et al.
Ester Clarisse do Couto Lopes et al.
Closed-loop bioelectronic devices offer a promising platform for responsive treatment to heterogeneous disease states. Glioblastoma, an aggressive form of brain cancer, has recently emerged as a focus of bioelectronic medicine through deliv...
Improving muscle recruitment via multi-electrode transcutaneous spinal cord stimulation using automated selectivity-driven algorithms [0.03%]
基于自动化选择驱动算法的多电极经皮脊髓刺激改善肌肉募集能力
Mouhamed Zorkot,Solaiman Shokur,Riccardo Carpineto et al.
Mouhamed Zorkot et al.
Spinal cord injury (SCI) severely impairs motor function and quality of life. Transcutaneous spinal cord stimulation (tSCS) has emerged as a promising non-invasive neuromodulation technique to restore voluntary motor function by engaging sp...
Dose-optimized HILT promotes peripheral nerve repair through BMP4-Smad9-mediated inhibition of neuroinflammation and oxidative stress [0.03%]
剂量优化的HILT通过BMP4-Smad9介导的抑制神经炎症和氧化应激促进外周神经再生
Lanlan Gong,Danyang Li,Xiaojing Zhao et al.
Lanlan Gong et al.
Evidence has shown that high-intensity laser therapy (HILT) may be beneficial for recovery after peripheral nerve injury (PNI). However, the optimized doses and effective mechanisms remain unclear. The present study sought to explore the ef...
A vertically integrated system for tracking and assessing cell-cycle-aware phenotypes under confinement [0.03%]
一种垂直集成系统，在约束条件下跟踪和评估细胞周期意识表型并进行评估
Melissa Pezzotti,Eloisa Torchia,Julius Zimmermann et al.
Melissa Pezzotti et al.
Quantitative cell biology often examines migration and cell-cycle (CC) progression separately, limiting insights into their interplay under spatial constraints. Here, we present a vertically integrated platform combining multiplexed fluores...
Fat promotes growth and invasion in a 3D microfluidic tumor model of triple-negative breast cancer [0.03%]
脂肪促进三阴性乳腺癌三维微流体肿瘤模型中的生长和侵袭
Maryam Kohram,Carolina Trenado-Yuste,Molly C Brennan-Smith et al.
Maryam Kohram et al.
Diet influences the levels of small molecules that circulate in plasma and interstitial fluid, altering the biochemical composition of the tumor microenvironment (TME). These circulating nutrients have been associated with how tumors grow a...
Computational modeling of human vagus nerve stimulation with three-dimensional fascicular morphology [0.03%]
基于三维神经束形态的人工迷走神经刺激的计算模型研究
Daniel P Marshall,Aniruddha R Upadhye,Ozge N Buyukcelik et al.
Daniel P Marshall et al.
Implanted vagus nerve stimulation is FDA-approved to treat epilepsy, depression, and stroke sequelae and is under development for other disorders such as heart failure and rheumatoid arthritis. Anatomically realistic computational models en...
Tiger Haoran Shi,Yu-Tang Huang,Hyunsu Jeon et al.
Tiger Haoran Shi et al.
Cellular 3D cancer spheroid technologies are novel tools that facilitate large-scale drug screening to bridge the in vitro-in vivo gap, without the cross-species effects of animal models. However, many spheroid studies fail to achieve I C ...
New concept in wound infection management: From bacterial eradication to microbiome modulation [0.03%]
伤口感染管理新概念：从细菌根除到微生物群调节
Tingting Hu,Zihan Chen,Zhe Yin et al.
Tingting Hu et al.
Wound infection represents a significant challenge in clinical practice. Traditional wound management, targeting sterility and relying on strategies of broad-spectrum bactericidal activity and antibiotic dependence, achieves partial infecti...