Analysis of immune cell infiltration landscape and identification of diagnostic biomarkers in ankylosing spondylitis [0.03%]
强直性脊柱炎免疫细胞浸润景观分析及诊断生物标志物识别
Meng Chen,Shanbang Zhu,Yue Gu et al.
Meng Chen et al.
Ankylosing spondylitis (AS), characterized by inflammation of sacroiliac joints and spinal attachments, has an unclear pathogenesis. This study aims to screen and authenticate immune cell-associated biomarkers in AS. Two Gene Expression Omn...
PDPN+ cancer-associated fibroblasts correlate with the neoadjuvant immunotherapy response in gastric cancer [0.03%]
PDPN+肿瘤相关成纤维细胞与胃癌新辅助免疫治疗反应的相关性研究
Mi Jian,Zhensong Yang,Yutao Tang et al.
Mi Jian et al.
The achievement of pathological complete response (pCR) with neoadjuvant therapy can significantly improve prognosis in patients with gastric cancer (GC). GC tissues demonstrating pCR after immunotherapy exhibited increased stiffness and pr...
A fully implantable sensorized artificial urinary bladder to restore continence and fullness monitoring [0.03%]
一种全植入式传感器化人工尿膀胱以恢复控尿和充盈感监测能力
F Semproni,V Iacovacci,S Musco et al.
F Semproni et al.
A fully implantable sensorized organ to replace the natural urinary bladder holds considerable promise for patients undergoing radical cystectomy. Clinical options to restore continence include urine redirection to wearable bags or reconstr...
Elevated hydrostatic pressure destabilizes VE-cadherin junctions in a time and shear stress dependent manner: An endothelium-on-chip study [0.03%]
升高的静水压通过时间和剪切应力依赖的方式破坏血管内皮细胞间的VE-钙黏蛋白连接：芯片上的内皮细胞研究
Pranav Vasanthi Bathrinarayanan,Thomas Abadie,Patricia Perez Esteban et al.
Pranav Vasanthi Bathrinarayanan et al.
Despite the effects of shear stress on endothelial biology having been extensively researched, the effects of hydrostatic vascular pressure at extremely low shear stresses have been largely ignored. In the current study, we employ a microfl...
Non-contact radiofrequency stimulation to the olfactory nerve of human subjects [0.03%]
人脑嗅神经的非接触式无线电频率刺激
Junsoo Bok,Eun-Seong Kim,Juchan Ha et al.
Junsoo Bok et al.
Damage to the olfactory nerve, caused by aging, trauma, or neurological disorders, can lead to smell loss, negatively impacting quality of life, taste perception, safety, and emotional well-being. Currently, olfactory training, which involv...
A modular and reconfigurable microfluidic device for culturing spheroids under continuous perfusion [0.03%]
一种用于连续灌注条件下培养类器官球的模块化可重构微流控器件
Hiba Aljayyousi,Sarah Sahloul,Ajymurat Orozaliev et al.
Hiba Aljayyousi et al.
3D cell spheroids have become crucial in vitro models for biomedical research, yet maintaining their growth and viability remains challenging due to diffusion limitations. We developed a versatile microfluidic modular device with a reconfig...
Single-cell RNA and bulk sequencing analysis reveals that formononetin inhibits GTSF1 to exert anti-osteosarcoma effects [0.03%]
单细胞RNA和批量测序分析表明异甘草素通过抑制GTSF1发挥抗骨肉瘤效应
Tianyu Xie,Jiming Liang,Chengsen Lin et al.
Tianyu Xie et al.
As the most common primary malignant bone tumor, osteosarcoma (OS) is characterized by drug resistance and poor prognosis, highlighting the urgent need for promising therapeutic agents. Formononetin (FMN), a natural product derived from Spa...
The role of mechanobiology in bone and cartilage model systems in characterizing initiation and progression of osteoarthritis [0.03%]
骨和软骨模型系统中的机悈生物学在表征骨关节炎的发生和发展中的作用
Tom Hodgkinson,Isabel N Amado,Fergal J O&#x;Brien et al.
Tom Hodgkinson et al.
Multifaceted changes in the mechanobiological environment of skeletal joints, at multiple length scales, are central to the development of diseases-like osteoarthritis (OA). Recent evidence demonstrates related mechanical alterations in bot...
Dynamic mapping of network-level LTP in the hippocampus via high-resolution bioelectrical sensing [0.03%]
基于高分辨率生物电学感应的海马区网络水平LTP动态图谱绘制技术
Shahrukh Khanzada,Xin Hu,Brett Addison Emery et al.
Shahrukh Khanzada et al.
Understanding the complexity of neural network dynamics demands advanced biosensing technologies capable of capturing large-scale interactions with high spatial and temporal precision. Traditional approaches, such as patch-clamp and field r...
Quercetin targets the Ccl4-Ccr5 axis to relieve neuropathic pain after spinal cord injury [0.03%]
槲皮素通过靶向Ccl4-Ccr5轴缓解脊髓损伤后的神经病理性疼痛
Xiangsheng Zhang,Yu Cao,Lu Li et al.
Xiangsheng Zhang et al.
Spinal cord injury (SCI) severely disrupts the central nervous system, with neuropathic pain (NP) emerging as a prevalent and challenging complication, affecting approximately two-thirds of affected individuals. This study aims to explore t...