Geometrically engineered organoid units and their assembly for pre-construction of organ structures [0.03%]
几何工程类器官单元及其组装以预先构建器官结构
Ayaka Kadotani,Gen Hayase,Daisuke Yoshino
Ayaka Kadotani
Regenerative medicine is moving from the nascent to the transitional stage as researchers are actively engaged in creating mini-organs from pluripotent stem cells to construct artificial models of physiological and pathological conditions. ...
High cell throughput, programmable fixation reveals the RNA and protein co-regulation with spatially resolved NFκB pseudo-signaling [0.03%]
高通量、可编程固定技术揭示具有空间分辨率的NFκB假信号转导中的RNA和蛋白质的共调控关系
Nicholas Zhang,Mingshuang Wang,Dhruv Nambiar et al.
Nicholas Zhang et al.
RNA translation to protein is paramount to creating life, yet RNA and protein correlations vary widely across tissues, cells, and species. To investigate these perplexing results, we utilize a time-series fixation method that combines stati...
Stacking model framework reveals clinical biochemical data and dietary behavior features associated with type 2 diabetes: A retrospective cohort study [0.03%]
基于堆积模型框架的一种关于2型糖尿病的回顾性队列研究：临床生化数据和饮食行为特征与2型糖尿病相关性的研究
Yong Fu,Xinghuan Liang,Xi Yang et al.
Yong Fu et al.
Background: Type 2 diabetes mellitus (T2DM) is the most common type of diabetes, accounting for around 90% of all diabetes. Studies have found that dietary habits and biochemical metabolic changes are closely related to T2DM disease surveil...
Rohit Nayak,Mengtong Duan,Bill Ling et al.
Rohit Nayak et al.
Gas vesicles (GVs) based on acoustic reporter genes have emerged as potent contrast agents for cellular and molecular ultrasound imaging. These air-filled, genetically encoded protein nanostructures can be expressed in a variety of cell typ...
Intercellular junction-driven stromal cell stacking in a confined 3D microcavity [0.03%]
封闭式三维微腔内细胞间连接驱动的基质细胞堆叠现象
Avelino Dos Santos Da Costa,Hyuntae Jeong,Ramesh Subbiah et al.
Avelino Dos Santos Da Costa et al.
Understanding the detailed mechanisms driving fibroblast migration within native tissue settings during pathophysiological events presents a critical research challenge. In this study, we elucidate how stromal cells migrate and contribute t...
Apoptosis-associated genetic mechanisms in the transition from rheumatoid arthritis to osteoporosis: A bioinformatics and functional analysis approach [0.03%]
从类风湿关节炎到骨质疏松的过渡中与细胞凋亡相关的遗传机制：生物信息学和功能分析方法
Hao-Ju Lo,Chun-Hao Tsai,Tsan-Wen Huang
Hao-Ju Lo
This study explores the mechanisms of glucocorticoid-induced osteoporosis (OP) and Rheumatoid arthritis (RA), focusing on apoptosis and its role in the progression from RA to OP. Using microarray data from the GEO database, differential gen...
M/EEG source localization for both subcortical and cortical sources using a convolutional neural network with a realistic head conductivity model [0.03%]
基于现实脑组织导电模型的卷积神经网络联合皮层和皮层下脑区的源定位方法研究
Hikaru Yokoyama,Naotsugu Kaneko,Noboru Usuda et al.
Hikaru Yokoyama et al.
While electroencephalography (EEG) and magnetoencephalography (MEG) are well-established noninvasive methods in neuroscience and clinical medicine, they suffer from low spatial resolution. Electrophysiological source imaging (ESI) addresses...
Jillian Cwycyshyn,Cooper Stansbury,Walter Meixner et al.
Jillian Cwycyshyn et al.
The advent of advanced robotic platforms and workflow automation tools has revolutionized the landscape of biological research, offering unprecedented levels of precision, reproducibility, and versatility in experimental design. In this wor...
Toward assessment of rupture risk predictors in abdominal aortic aneurysms including intraluminal thrombus based on 3D+t ultrasound images [0.03%]
基于3D+T超声图像的包括腔内血栓在内的腹主动脉瘤破裂风险预测因子的评估研究
Arjet Nievergeld,Judith Fonken,Esther Maas et al.
Arjet Nievergeld et al.
Image-based patient-specific rupture risk analysis for abdominal aortic aneurysms (AAAs) has shown considerable promise. However, clinical translation has been hampered by the use of invasive and costly imaging modalities. Despite being a p...
3D confinement alters smooth muscle cell responses to chemical and mechanical cues [0.03%]
三维限制改变了化学和机械刺激引起的平滑肌细胞响应
Farnaz Hemmati,Ayuba Akinpelu,Daniel Chinedu Nweze et al.
Farnaz Hemmati et al.
Smooth muscle cell (SMC) phenotypic switching is a hallmark of many vascular diseases. Although prior work has established that chemical and mechanical cues contribute to SMC phenotypic switching, the impact of three-dimensional (3D) confin...