Naiara Santana-Codina,Joseph D Mancias,Alec C Kimmelman
Naiara Santana-Codina
Autophagy is a highly conserved and regulated process that targets proteins and damaged organelles for lysosomal degradation to maintain cell metabolism, genomic integrity, and cell survival. The role of autophagy in cancer is dynamic and d...
Joshi Niraj,Anniina Färkkilä,Alan D D&#x;Andrea
Joshi Niraj
Fanconi anemia (FA) is a complex genetic disorder characterized by bone marrow failure (BMF), congenital defects, inability to repair DNA interstrand cross-links (ICLs), and cancer predisposition. FA presents two seemingly opposite characte...
Yun Zhang,Guillermina Lozano
Yun Zhang
The p53 tumor suppressor has been studied for decades, and still there are many questions left unanswered. In this review, we first describe the current understanding of the wild-type p53 functions that determine cell survival or death, and...
Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer [0.03%]
同源重组修复以及BRCA1、BRCA2及相关蛋白质在基因组稳定性和肿瘤发生中的作用
Chun-Chin Chen,Weiran Feng,Pei Xin Lim et al.
Chun-Chin Chen et al.
Germ-line and somatic mutations in genes that promote homology-directed repair (HDR), especially BRCA1 and BRCA2, are frequently observed in several cancers, in particular, breast and ovary but also prostate and other cancers. HDR is critic...
Clémentine Le Magnen,Michael M Shen,Cory Abate-Shen
Clémentine Le Magnen
Historically, it has been widely presumed that differentiated cells are determined during development and become irreversibly committed to their designated fates. In certain circumstances, however, differentiated cells can display plasticit...
Stress-Induced Mutagenesis: Implications in Cancer and Drug Resistance [0.03%]
应激诱发的诱变：其在癌症和药物抗性中的意义
Devon M Fitzgerald,P J Hastings,Susan M Rosenberg
Devon M Fitzgerald
Genomic instability underlies many cancers and generates genetic variation that drives cancer initiation, progression, and therapy resistance. In contrast with classical assumptions that mutations occur purely stochastically at constant, gr...