Molecular Pathogenesis and Therapeutic Response of Diffuse Large B Cell Lymphoma Genetic Subtypes [0.03%]
弥漫性大B细胞淋巴瘤遗传亚型的分子病理和治疗反应
James D Phelan,Julius C Enssle,Sean R Corcoran et al.
James D Phelan et al.
Diffuse large B cell lymphoma (DLBCL) is a clinically and genetically heterogeneous disease. Molecular profiling studies in DLBCL have identified three distinct disease subtypes using gene expression profiling, whereas mutation analysis of ...
Pilar O&#x;Neal,Sonya Kumar Bharathkar,Amelia C McCue et al.
Pilar O&#x;Neal et al.
Cytokines represent a diverse group of soluble proteins that play crucial roles in mediating cellular communication in order to regulate cell fate, particularly in the context of the immune system. Because of their critical roles in control...
The Role of Phase-Separated Condensates in Fusion Oncoprotein-Driven Cancers [0.03%]
融合致癌蛋白驱动的癌症中相分离凝聚体的作用
Hazheen K Shirnekhi,Bappaditya Chandra,Richard W Kriwacki
Hazheen K Shirnekhi
Fusion oncoproteins (FOs) resulting from in-frame chromosomal translocations are associated with many aggressive cancers with poor patient outcomes. Several FOs are now understood to perform their oncogenic functions within biomolecular con...
Impact of Chromosomal Instability and Aneuploidy in Cancer Development [0.03%]
染色体不稳定性和非整倍体现在癌症发生中的作用
Amanda K Mennie,Brittiny Dhital,Peter Ly
Amanda K Mennie
Somatic human cells contain a diploid genome consisting of 23 pairs of chromosomes. The maintenance of this diploid state is essential across all layers of biological organization, ranging from the physiology of individual cells to the prop...
The Hallmarks of Ferroptosis [0.03%]
铁死亡的特征
Scott J Dixon,Brent R Stockwell
Scott J Dixon
Ferroptosis is a nonapoptotic, iron-dependent form of cell death that can be activated in cancer cells by natural stimuli and synthetic agents. Three essential hallmarks define ferroptosis, namely: the loss of lipid peroxide repair capacity...
Chemical Proteomics-Guided Discovery of Covalent Ligands for Cancer Proteins [0.03%]
基于化学蛋白质组学的抗癌药物导向发现及其机制研究
Xiaoyu Zhang,Benjamin F Cravatt
Xiaoyu Zhang
Advances in genome sequencing and editing technologies have enriched our understanding of the biochemical pathways that drive tumorigenesis. Translating this knowledge into new medicines for cancer treatment, however, remains challenging, a...
Jordan H Driskill,Josephine K Dermawan,Cristina R Antonescu et al.
Jordan H Driskill et al.
Gene fusions are well-known drivers of cancer and are potent targets for molecular therapy. An emerging spectrum of human tumors harbors recurrent and pathognomonic gene fusions that involve the transcriptional coactivator YAP1 (which encod...
Colleen R Reczek,Navdeep S Chandel
Colleen R Reczek
Reactive oxygen species (ROS), now appreciated for their cellular signaling capabilities, have a dual role in cancer. On the one hand, ROS can promote protumorigenic signaling, facilitating cancer cell proliferation, survival, and adaptatio...
Complex Roles of PTPN11/SHP2 in Carcinogenesis and Prospect of Targeting SHP2 in Cancer Therapy [0.03%]
PTPN11/SHP2在 carcinogenesis中的复杂作用及靶向SHP2在癌症治疗中的前景
Alexander Scheiter,Li-Chun Lu,Lilian H Gao et al.
Alexander Scheiter et al.
The non-receptor tyrosine phosphatase SHP2 has been at the center of cell signaling research for three decades. SHP2 is required to fully activate the RTK-RAS-ERK cascade, although the underlying mechanisms are not completely understood. PT...
Charles L Limoli,Marie-Catherine Vozenin
Charles L Limoli
Ultrahigh-dose rate FLASH radiotherapy (FLASH-RT) is a potentially paradigm-shifting treatment modality that holds the promise of expanding the therapeutic index for nearly any cancer. At the heart of this exciting technology comes the capa...