Kristopher R Bosse,Robbie G Majzner,Crystal L Mackall et al.
Kristopher R Bosse et al.
Immune-based therapies have now been credentialed for pediatric cancers with the robust efficacy of chimeric antigen receptor (CAR) T cells for pediatric B cell acute lymphocytic leukemia (ALL), offering a chance of a cure for children with...
The Epithelial-to-Mesenchymal Transition (EMT) in Development and Cancer [0.03%]
上皮间质转化（EMT）在发育和癌症中的作用
Alexandre Francou,Kathryn V Anderson
Alexandre Francou
Epithelial-to-mesenchymal transitions (EMTs) are complex cellular processes where cells undergo dramatic changes in signaling, transcriptional programming, and cell shape, while directing the exit of cells from the epithelium and promoting ...
Luke T Izzo,Hayley C Affronti,Kathryn E Wellen
Luke T Izzo
Metabolic and epigenetic reprogramming are characteristics of cancer cells that, in many cases, are linked. Oncogenic signaling, diet, and tumor microenvironment each influence the availability of metabolites that are substrates or inhibito...
Luisa Escobar-Hoyos,Katherine Knorr,Omar Abdel-Wahab
Luisa Escobar-Hoyos
RNA splicing, the enzymatic process of removing segments of premature RNA to produce mature RNA, is a key mediator of proteome diversity and regulator of gene expression. Increased systematic sequencing of the genome and transcriptome of ca...
Rushika M Perera,Chiara Di Malta,Andrea Ballabio
Rushika M Perera
Cancer cells have an increased demand for energy sources to support accelerated rates of growth. When nutrients become limiting, cancer cells may switch to nonconventional energy sources that are mobilized through nutrient scavenging pathwa...
Naiara Santana-Codina,Joseph D Mancias,Alec C Kimmelman
Naiara Santana-Codina
Autophagy is a highly conserved and regulated process that targets proteins and damaged organelles for lysosomal degradation to maintain cell metabolism, genomic integrity, and cell survival. The role of autophagy in cancer is dynamic and d...
Joshi Niraj,Anniina Färkkilä,Alan D D&#x;Andrea
Joshi Niraj
Fanconi anemia (FA) is a complex genetic disorder characterized by bone marrow failure (BMF), congenital defects, inability to repair DNA interstrand cross-links (ICLs), and cancer predisposition. FA presents two seemingly opposite characte...
Yun Zhang,Guillermina Lozano
Yun Zhang
The p53 tumor suppressor has been studied for decades, and still there are many questions left unanswered. In this review, we first describe the current understanding of the wild-type p53 functions that determine cell survival or death, and...
Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer [0.03%]
同源重组修复以及BRCA1、BRCA2及相关蛋白质在基因组稳定性和肿瘤发生中的作用
Chun-Chin Chen,Weiran Feng,Pei Xin Lim et al.
Chun-Chin Chen et al.
Germ-line and somatic mutations in genes that promote homology-directed repair (HDR), especially BRCA1 and BRCA2, are frequently observed in several cancers, in particular, breast and ovary but also prostate and other cancers. HDR is critic...
Clémentine Le Magnen,Michael M Shen,Cory Abate-Shen
Clémentine Le Magnen
Historically, it has been widely presumed that differentiated cells are determined during development and become irreversibly committed to their designated fates. In certain circumstances, however, differentiated cells can display plasticit...