Nutritional Preconditioning in Cancer Treatment in Relation to DNA Damage and Aging [0.03%]
营养预处理在癌症治疗中的作用及其与DNA损伤和衰老的关系
Winnie M C van den Boogaard,Marry M van den Heuvel-Eibrink,Jan H J Hoeijmakers et al.
Winnie M C van den Boogaard et al.
Dietary restriction (DR) is the most successful nutritional intervention for extending lifespan and preserving health in numerous species. Reducing food intake triggers a protective response that shifts energy resources from growth to maint...
Kevin Kos,Karin E de Visser
Kevin Kos
The microenvironment of breast cancer hosts a dynamic cross talk between diverse players of the immune system. While cytotoxic immune cells are equipped to control tumor growth and metastasis, tumor-corrupted immunosuppressive immune cells ...
Joe Nassour,Tobias T Schmidt,Jan Karlseder
Joe Nassour
Decades of study on cell cycle regulation have provided great insight into human cellular life span barriers, as well as their dysregulation during tumorigenesis. Telomeres, the extremities of linear chromosomes, perform an essential role i...
Ex Vivo Analysis of Primary Tumor Specimens for Evaluation of Cancer Therapeutics [0.03%]
原发性肿瘤样本的体外分析以评估癌症治疗药物的效果
Cristina E Tognon,Rosalie C Sears,Gordon B Mills et al.
Cristina E Tognon et al.
The use of ex vivo drug sensitivity testing to predict drug activity in individual patients has been actively explored for almost 50 years without delivering a generally useful predictive capability. However, extended failure should not be ...
Tuomas Tammela,Julien Sage
Tuomas Tammela
Cancer arises from a single cell through a series of acquired mutations and epigenetic alterations. Tumors gradually develop into a complex tissue comprised of phenotypically heterogeneous cancer cell populations, as well as noncancer cells...
Kristopher R Bosse,Robbie G Majzner,Crystal L Mackall et al.
Kristopher R Bosse et al.
Immune-based therapies have now been credentialed for pediatric cancers with the robust efficacy of chimeric antigen receptor (CAR) T cells for pediatric B cell acute lymphocytic leukemia (ALL), offering a chance of a cure for children with...
The Epithelial-to-Mesenchymal Transition (EMT) in Development and Cancer [0.03%]
上皮间质转化（EMT）在发育和癌症中的作用
Alexandre Francou,Kathryn V Anderson
Alexandre Francou
Epithelial-to-mesenchymal transitions (EMTs) are complex cellular processes where cells undergo dramatic changes in signaling, transcriptional programming, and cell shape, while directing the exit of cells from the epithelium and promoting ...
Luke T Izzo,Hayley C Affronti,Kathryn E Wellen
Luke T Izzo
Metabolic and epigenetic reprogramming are characteristics of cancer cells that, in many cases, are linked. Oncogenic signaling, diet, and tumor microenvironment each influence the availability of metabolites that are substrates or inhibito...
Luisa Escobar-Hoyos,Katherine Knorr,Omar Abdel-Wahab
Luisa Escobar-Hoyos
RNA splicing, the enzymatic process of removing segments of premature RNA to produce mature RNA, is a key mediator of proteome diversity and regulator of gene expression. Increased systematic sequencing of the genome and transcriptome of ca...
Rushika M Perera,Chiara Di Malta,Andrea Ballabio
Rushika M Perera
Cancer cells have an increased demand for energy sources to support accelerated rates of growth. When nutrients become limiting, cancer cells may switch to nonconventional energy sources that are mobilized through nutrient scavenging pathwa...