Michael Dougan,Glenn Dranoff,Stephanie K Dougan
Michael Dougan
Blocking antibodies to the immune checkpoint receptors or their ligands have revolutionized the treatment of diverse malignancies. Many tumors are recognized by adaptive immunity, but these adaptive responses can be inhibited by immunosuppr...
Kelli A Connolly,Brittany Fitzgerald,Martina Damo et al.
Kelli A Connolly et al.
Mouse models for the study of cancer immunology provide excellent systems in which to test biological mechanisms of the immune response against cancer. Historically, these models have been designed to have different strengths based on the c...
Varun Sahu,Chao Lu
Varun Sahu
Chromatin dysfunction has been implicated in a growing number of cancers especially in children and young adults. In addition to chromatin modifying and remodeling enzymes, mutations in histone genes are linked to human cancers. Since the f...
Szu-Ying Chen,Ons Mamai,Rosemary J Akhurst
Szu-Ying Chen
Discovered over four decades ago, transforming growth factor β (TGFβ) is a potent pleiotropic cytokine that has context-dependent effects on most cell types. It acts as a tumor suppressor in some cancers and/or supports tumor progression ...
Martin W LaFleur,Arlene H Sharpe
Martin W LaFleur
Cancer immunotherapies, such as immune checkpoint blockade (ICB), have been used in a wide range of tumor types with immense clinical benefit. However, ICB does not work in all patients, and attempts to combine ICB with other immune-based t...
Nutritional Preconditioning in Cancer Treatment in Relation to DNA Damage and Aging [0.03%]
营养预处理在癌症治疗中的作用及其与DNA损伤和衰老的关系
Winnie M C van den Boogaard,Marry M van den Heuvel-Eibrink,Jan H J Hoeijmakers et al.
Winnie M C van den Boogaard et al.
Dietary restriction (DR) is the most successful nutritional intervention for extending lifespan and preserving health in numerous species. Reducing food intake triggers a protective response that shifts energy resources from growth to maint...
Kevin Kos,Karin E de Visser
Kevin Kos
The microenvironment of breast cancer hosts a dynamic cross talk between diverse players of the immune system. While cytotoxic immune cells are equipped to control tumor growth and metastasis, tumor-corrupted immunosuppressive immune cells ...
Joe Nassour,Tobias T Schmidt,Jan Karlseder
Joe Nassour
Decades of study on cell cycle regulation have provided great insight into human cellular life span barriers, as well as their dysregulation during tumorigenesis. Telomeres, the extremities of linear chromosomes, perform an essential role i...
Ex Vivo Analysis of Primary Tumor Specimens for Evaluation of Cancer Therapeutics [0.03%]
原发性肿瘤样本的体外分析以评估癌症治疗药物的效果
Cristina E Tognon,Rosalie C Sears,Gordon B Mills et al.
Cristina E Tognon et al.
The use of ex vivo drug sensitivity testing to predict drug activity in individual patients has been actively explored for almost 50 years without delivering a generally useful predictive capability. However, extended failure should not be ...
Tuomas Tammela,Julien Sage
Tuomas Tammela
Cancer arises from a single cell through a series of acquired mutations and epigenetic alterations. Tumors gradually develop into a complex tissue comprised of phenotypically heterogeneous cancer cell populations, as well as noncancer cells...