SDHB-associated paraganglioma in Saudi Arabia: High metastatic risk linked to a likely founder mutation [0.03%]
沙特阿拉伯的SDHB相关副神经节瘤：高转移风险与疑似创始人突变有关
Ali S Alzahrani,Balgees Alghamdi,Allianah Benito et al.
Ali S Alzahrani et al.
Context: SDHB-related pheochromocytoma and paraganglioma (PPGL) are associated with a high risk of metastasis. Minimal data are available on these genetically based tumors from the Middle East. ...
Clinical profile, treatment practices, and complications in chronic hypoparathyroidism in a Middle Eastern cohort [0.03%]
中东地区慢性低甲状旁腺素血症的临床特征、治疗实践和并发症分析
Fauzia Rashid,Budoor Alemadi,Elamin Abdelgadir et al.
Fauzia Rashid et al.
Context: Hypoparathyroidism is a rare but clinically significant endocrine disorder with an unknown prevalence and complication burden in our region. Obje...
Clinical characteristics, disease course, and clinical subgroups of young adults with type 2 diabetes [0.03%]
年轻2型糖尿病患者临床特征、病程及临床分型研究
Anu Sharma,Jose M Lazaro-Guevara,Devorah Stucki et al.
Anu Sharma et al.
Context: Type 2 diabetes (T2D) in young adults is an emerging entity distinct from that in older adults. Objective: To identify unique ...
Systematic or targeted molecular screening of SHOX gene variations in children with idiopathic short stature? [0.03%]
系统或靶向筛查SHOX基因变异在儿童特发性身材矮小中的作用？
Romee Pouliquen,Sebastien Schmitt,Tifenn Gueguen et al.
Romee Pouliquen et al.
Context: Diagnosing SHOX gene variations is important because growth hormone treatment is an approved option for affected children. Subtle clinical and radiological abnormalities were reported in SHOX deficiency associate...
Potential risk of neoplasms with fezolinetant: clinical evidence, mechanisms, and post-marketing implications [0.03%]
费佐林塔nt的潜在致瘤风险：临床证据、机制及上市后问题
Emma Boretti,Jean-Michel Dogné,Jonathan Douxfils
Emma Boretti
In 2023, the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) approved fezolinetant (Veozah® in the United States, Veoza® in Europe), a novel neurokinin 3 receptor (NK3R) antagonist and first-in-class nonhormonal...
High protein ingestion does not affect whole-body insulin sensitivity in individuals with overweight or obesity [0.03%]
高蛋白摄入不影响超重或肥胖个体的全身胰岛素敏感性
Oana Ancu,Astrid C Hauge-Evans,Fulvia Draicchio et al.
Oana Ancu et al.
Context: High protein diets (HPD), rich in branched-chain amino acids (BCAAs), are proposed to enhance glycemic control. The metabolic implications of elevated BCAAs in insulin resistance (IR) are unclear, but overactivat...
Effects of saccharin on insulin sensitivity in adult, overweight individuals without diabetes: a real-world pilot study [0.03%]
安赛蜜对超重且没有糖尿病的成年人胰岛素敏感性影响的现实世界试点研究
Kenny Kalin,Karin Rådholm,Lisa Olsson et al.
Kenny Kalin et al.
Context: It has been suggested that consumption of saccharin, a widely used artificial sweetener, decreases insulin sensitivity in rodents and humans, but studies show conflicting results. ...
Emma S Sutherland,Gihani Manodara,Ashley Gillon et al.
Emma S Sutherland et al.
Tampons are widely used menstrual products with prolonged mucosal contact, raising questions about their potential role in exposing females to endocrine-disrupting chemicals (EDCs). This study evaluated estrogenic activity in tampon extract...
Diazoxide choline extended-release (DCCR) use in Prader-Willi syndrome: patient selection, dosing, and management [0.03%]
戴索氧化胆碱缓释(DCCR)在普拉德-威利综合征中的应用：患者选择、剂量和管理
Jennifer M Miller,Ashley H Shoemaker,Parisa Salehi et al.
Jennifer M Miller et al.
Prader-Willi syndrome (PWS) is a rare genetic disorder marked by metabolic, endocrine, and behavioral challenges, with hyperphagia as a central feature contributing to significant health risks. Diazoxide choline extended-release (DCCR; VYKA...
Determinants of diagnostic delay in thyroid storm: a 12-year single-center cohort study [0.03%]
12年单中心队列研究决定甲状腺风暴诊断延迟的因素
Tetsuya Kawahara,Mikio Toda,Maiko Kanagawa et al.
Tetsuya Kawahara et al.
Objective: Thyroid storm is a life-threatening endocrine emergency. Although predictors of mortality have been described, determinants of diagnostic delay remain unclear. We aimed to identify factors associated with diagn...