Pemafibrate Improves Lipid and Liver Metabolism in Adult GH Deficiency: A Prospective Observational Study [0.03%]
pemafibrate改善成人生长激素缺乏患者的脂质和肝脏代谢：一项前瞻性观察研究
Hiroshi Iesaka,Kyu Yong Cho,So Nagai et al.
Hiroshi Iesaka et al.
Context: The outcomes of pemafibrate administration on hypertriglyceridemia and metabolic dysfunction-associated steatotic liver disease associated with adult growth hormone deficiency (AGHD) are unknown. ...
Julio Soto,Rucha Anant Patki,Lauren J Ehrlich et al.
Julio Soto et al.
Context: Bone age (BA) assessment and prediction of adult height (AdHt) has not been well studied in children with X-linked hypophosphatemia (XLH). Object...
Long-term Safety, Efficacy, and PROs: Phase 3 Study of Leuprolide Acetate 6-month IM Depot in Central Precocious Puberty [0.03%]
长效性、有效性和PROS：中央性早熟患儿注射醋酸亮丙瑞林六个月长效剂型的三期研究
Karen O Klein,Nelly Mauras,Sunil Nayak et al.
Karen O Klein et al.
Context: The long-term safety and efficacy of leuprolide acetate (LA) intramuscular (IM) depot in children with central precocious puberty (CPP) have not been examined. ...
Greater Concentrations of IGF Binding Protein-2 after Bariatric Surgery Compared with Diet [0.03%]
与单纯饮食相比，代谢手术后IGF结合蛋白水平更高
Chino Aneke-Nash,Sarah Borden,Emily G Werth et al.
Chino Aneke-Nash et al.
Context: Bariatric surgery causes greater sustained weight loss (WL) and metabolic improvements compared to lifestyle modification. It remains unclear which metabolic changes are solely attributable to WL and which also i...
Effect of Tofogliflozin on Skeletal Muscle Mitochondrial Function in Male Diabetic Mice With Muscle Atrophy [0.03%]
托格列净对糖尿病肌肉萎缩小鼠骨骼肌线粒体功能的影响
Chiaki Kishida,Maki Murakoshi,Hiroko Sakuma et al.
Chiaki Kishida et al.
Sodium-glucose cotransporter-2 (SGLT2) inhibitors are effective medications for type 2 diabetes (T2D), chronic kidney disease, and chronic heart failure regardless of diabetic status. However, concerns remain about their potential to reduce...
Disuse Bone Loss After Spinal Cord Injury: Scope and Challenges, Potential Mechanisms, Treatment, and Future Directions [0.03%]
脊髓损伤后的废用性骨丢失：范围和挑战、潜在机制、治疗及未来方向
Hesham A Tawfeek
Hesham A Tawfeek
Traumatic spinal cord injury (SCI) is a major insult that causes motor and sensory neurological deficits and multisystem dysfunction. The skeletal system is severely affected after SCI, with disuse bone loss being one of the most common and...
Embryo Culture Duration Is an Independent Risk Factor for Gestational Diabetes in Frozen Embryo Transfer Pregnancies [0.03%]
胚胎培养时间是冻胚移植妊娠期糖尿病的独立危险因素
Huijun Chen,Shujuan Ma,Yvonne Liu et al.
Huijun Chen et al.
Objective: To investigate whether prolonged embryo culture increases the risk of gestational diabetes mellitus (GDM) in pregnancies conceived via frozen embryo transfer (FET). ...
Bassam Bin-Abbas,Afaf Alsagheir,Balgees Alghamdi et al.
Bassam Bin-Abbas et al.
Context: The aim of this study was to characterize the molecular genetics of 1α-hydroxylase deficiency in the highly consanguineous population of Saudi Arabia, hypothesizing that the results will show a unique CYP27B1 ge...
Acyl-CoA Synthetase 5 Knockout and Inhibitors Protect Against Diet-Induced Obesity in Mice by Activating the Ileal Brake [0.03%]
乙酰辅酶A合成酶5敲除和抑制剂通过激活回肠制动作用保护小鼠免受高脂饮食诱导的肥胖影响
David R Powell,Isaac Van Sligtenhorst,Alan Main et al.
David R Powell et al.
Genes regulating body fat are shared by mice and humans, and mouse knockout phenotypes for known drug targets correlate well with drug efficacy, suggesting that mouse knockout phenotyping can identify anti-obesity drug targets. Mice with an...
Venous Thromboembolism Risk Associated With Relugolix-estradiol-norethisterone Acetate Combination Therapy [0.03%]
口服Relugolix复合激素制剂导致静脉血栓风险增加
Jonathan Douxfils,Marie Didembourg,Lorraine Maitrot-Mantelet et al.
Jonathan Douxfils et al.
Background: Relugolix, an oral GnRH receptor antagonist, is effective in treating uterine myomas and endometriosis. However, concerns persist regarding the venous thromboembolism (VTE) risk associated with its combination...