Exposure of male mice to nicotine leads to metabolic dysfunction in their male and female offspring [0.03%]
尼古丁暴露会导致小鼠后代代谢功能障碍
Stephanie Aguiar,Truman Natividad,Daniel Davis et al.
Stephanie Aguiar et al.
Paternal exposure to nicotine has been linked to altered metabolic phenotypes in offspring, yet the underlying mechanisms and sex-specific outcomes remain elusive. In this study, we investigated the effects of paternal nicotine exposure on ...
Transcriptomic and epigenetic alterations in aging-related genes in the medaka liver due to ancestral BPA exposure [0.03%]
斑马鱼肝脏因祖先双酚A暴露引起与衰老相关基因的转录组和表观遗传改变
Sourav Chakraborty,Thomas J Nickel,Santosh Anand et al.
Sourav Chakraborty et al.
Environmental endocrine disruptors (EEDs) can accelerate the onset of age-associated liver dysfunction, yet the underlying molecular mechanisms remain poorly understood. Whether unexposed offspring experience differential aging of the liver...
Hepatic embolization for Cushing syndrome from metastatic tumors: a single-center case series [0.03%]
库欣综合征肝转移瘤的肝动脉化疗栓塞治疗：单中心病例系列分析
Shuyao Zhang,Jorge Esteban Mosquera,Clive Musonza et al.
Shuyao Zhang et al.
Background: Cushing syndrome (CS) from metastatic adrenocortical carcinoma (ACC) or neuroendocrine tumors (NETs) presents a therapeutic challenge when surgery is not feasible. Liver-directed embolization, including bland ...
Circulating soluble CXCR4 fails to differentiate subtypes of primary aldosteronism [0.03%]
循环中的可溶性CXCR4无法区分原发性醛固酮增多症的亚型
Wanying Chao,Yan Ren,Mingxi Zou et al.
Wanying Chao et al.
Accurate subtyping of primary aldosteronism (PA) is essential for treatment selection. This study examined whether soluble CXC chemokine receptor type 4 (sCXCR4) in peripheral blood reflects adrenal CXCR4 expression assessed by 68Ga-pentixa...
Revisiting the TSH range in older adults: associations between subclinical hypothyroidism and geriatric conditions [0.03%]
重访老年人的促甲状腺激素范围：亚临床甲状腺功能减退与老年综合征之间的关系
Toshiki Kogai,Hideyoshi Kaga,Toyoyoshi Uchida et al.
Toshiki Kogai et al.
Context: Thyroid-stimulating hormone (TSH) levels physiologically increase with age. Applying a fixed adult reference range to older adults may cause overdiagnosis of subclinical hypothyroidism (SCH). This study examined ...
Prediction of distant metastases at diagnosis in medullary thyroid cancer: combining calcitonin with lymph node imaging [0.03%]
结合降钙素与淋巴结影像预测甲状腺髓样癌初诊时远处转移的可能性
Leonoor E Schonebaum,Hossein Razaghi Siahroudi,Layal Chaker et al.
Leonoor E Schonebaum et al.
Context: Current guidelines recommend performing preoperative additional imaging in patients with medullary thyroid cancer (MTC) when calcitonin levels exceed 500 pg/mL to detect distant metastases (M1). However, this rec...
Haoning Howard Cen,Aurora J Mattison,Alireza Omidi et al.
Haoning Howard Cen et al.
Context: Insulin action is critical for energy homeostasis and its dysfunction in muscle cells is associated with type 2 diabetes. Insulin receptor (INSR) internalization and cell-surface dynamics at rest and during insul...
Androgen and estrogen secretory dynamics in longitudinally followed moderately and late preterm infant girls [0.03%]
纵向随访的中度和晚期早产女婴的雄激素和雌激素分泌动力学
Carina Ankarberg-Lindgren,Kerstin Allvin,Jovanna Dahlgren
Carina Ankarberg-Lindgren
Context: Mini-puberty is a period when the hypothalamic-pituitary-gonadal (HPG) axis is activated and is believed to create the basis for future fertility. In prematurely born females, delayed HPG axis activity and lower ...
Associations between maternal prepregnancy body mass index and maternal and cord blood metabolome [0.03%]
孕前体质指数与母体和脐带血代谢组的关系
Heidi Sormunen-Harju,Polina V Girchenko,Eero Kajantie et al.
Heidi Sormunen-Harju et al.
Context: Prepregnancy body mass index (pBMI) is associated with the maternal metabolome during pregnancy. However, evidence remains inconclusive whether pBMI is also associated with alterations in the fetal cord blood met...