Norbert Albers,Sarah Cadarette,Ben Feakins et al.
Norbert Albers et al.
Long-acting growth hormone (LAGH) has the potential to improve adherence and outcomes over daily somatropin in growth hormone deficiency (GHD). Whereas daily somatropin products are molecularly identical, LAGHs are molecularly distinct; add...
Effect of Vitamin D on Regression to Normal Glucose Regulation in Adults With Prediabetes [0.03%]
维生素D对成人前糖尿病恢复正常血糖调节的影响
Philip M Kretschmer,Ethan M Balk,Anastassios G Pittas
Philip M Kretschmer
Meta-analyses of clinical trials have shown that vitamin D lowers the risk of progression from prediabetes to diabetes. Less is known about whether vitamin D promotes regression to normal glucose regulation (NGR). We conducted a systematic ...
Real-world Outcome of Vosoritide Treatment in Children With Achondroplasia: A 12-month Retrospective Observational Study [0.03%]
vosoritide治疗侏儒症儿童的现实世界结果：一项为期12个月的回顾性观察研究
Susanna Reincke,Oliver Semler,Shino Junghänel-Welzing et al.
Susanna Reincke et al.
Context: Vosoritide is the first approved targeted therapy for achondroplasia (ACH) based on increased annualized growth velocity in clinical trials. The aim of our project was an assessment of the real-world setting and ...
Dimuthu Tharanga Muthukuda,Kamani Dhanushka Liyanaarachchi,Kushalee Poornima Jayawickreme et al.
Dimuthu Tharanga Muthukuda et al.
Background: Severe Cushing syndrome is a medical emergency. Etomidate is the only IV option available for treating hypercortisolism, especially in critically ill patients obviating oral medications. ...
Growth Response to Weekly Somapacitan Therapy in Children With GH Deficiency Is Related to GH Thresholds in GH Stimulation Testing [0.03%]
生长激素刺激试验中GH阈值与GH缺乏儿童接受Somapacitan周期治疗的生长反应相关
Philippe F Backeljauw,Claudia Boettcher,Michael Højby et al.
Philippe F Backeljauw et al.
Context: The lack of a severity definition and standardized GH cutoff level for GH deficiency (GHD) diagnosis in children leads to ambiguity in the interpretation of GH stimulation tests and treatment recommendations. ...
Resting Energy Expenditure and Metabolic Features in Children With Septo-Optic Dysplasia [0.03%]
蝶鞍板发育不全儿童的静息能量消耗和代谢特点
David J Cullingford,Jacqueline A Curran,Mary B Abraham et al.
David J Cullingford et al.
Context: Septo-optic dysplasia (SOD) is a major cause of congenital hypopituitarism and is known to be associated with overweight and obesity in up to 44% of children. Given the role of the hypothalamus in hormonal regula...
Clinical Features and Plasma Metabolites Analysis in Obese Chinese Children With Nonalcoholic Fatty Liver Disease [0.03%]
肥胖儿童非酒精性脂肪肝的临床特征及血浆代谢物分析
Xiaoxiao Liu,Shifeng Ma,Jing Li et al.
Xiaoxiao Liu et al.
Objective: This study aimed to investigate the clinical characteristics and plasma metabolites of nonalcoholic fatty liver disease (NAFLD) in obese Chinese children and to develop machine learning-based NAFLD diagnostic m...
Osilodrostat Treatment for Adrenal and Ectopic Cushing Syndrome: Integration of Clinical Studies With Case Presentations [0.03%]
Osilodrostat治疗肾上腺和异位库欣综合症：临床研究与病例报告的结合
Maria Fleseriu,Richard J Auchus,Irina Bancos et al.
Maria Fleseriu et al.
Although most cases of endogenous Cushing syndrome are caused by a pituitary adenoma (Cushing disease), approximately one-third of patients present with ectopic or adrenal causes. Surgery is the first-line treatment for most patients with C...
Adult Growth Hormone Deficiency (AGHD) and Outcomes (NordiNet and ANSWER) [0.03%]
成人生长激素缺乏症(AGHD)和结局(NordiNet和ANSWER)
John D Carmichael,Atil Y Kargi,Laura Dichtel et al.
John D Carmichael et al.
Adult growth hormone deficiency (AGHD) is a rare disease with both physiological and psychological effects for untreated patients. AGHD symptoms can improve over time with GH treatment. Here we have analyzed the long-term effectiveness and ...