Impacts of new sex- and age-specific TSH and FT4 reference ranges on thyroid status and metabolic disorder associations [0.03%]
新的性别和年龄特异性TSH和FT4参考范围对甲状腺状态及与代谢紊乱关联的影响
Sayaka Yamada,Kazuhiko Horiguchi,Masako Akuzawa et al.
Sayaka Yamada et al.
Context: Thyroid hormone levels vary by age, sex, and genetic background; yet most clinical reference ranges (RRs) do not account for these factors, potentially leading to misclassification of thyroid status and missed as...
Challenges in the management of bone metastases: focus on differentiated thyroid cancer and neuroendocrine tumors [0.03%]
骨转移瘤治疗的挑战：以分化型甲状腺癌和神经内分泌肿瘤为例
Julie Chen,Joy Y Wu
Julie Chen
Bone metastases represent an uncommon but clinically significant complication in endocrine malignancies including differentiated thyroid cancer and neuroendocrine tumors. Although these malignancies typically follow an indolent course, the ...
Optimal visceral adipose tissue thresholds that minimize risk for osteoporosis and/or diabetes in midlife women [0.03%]
最佳的内脏脂肪组织阈值可将中年妇女骨质疏松症和/或糖尿病的风险降至最低
Sheryl Yen Pin Tan,Kothandaraman Narasimhan,Beverly Wen Xin Wong et al.
Sheryl Yen Pin Tan et al.
Context: Visceral adipose tissue (VAT) is increasingly recognized as a key determinant of diabetes and osteoporosis risk. However, clinically relevant VAT thresholds associated with both osteoporosis and type 2 diabetes r...
The sphingosine-1-phosphate pathway is differentially activated in human gestational tissues [0.03%]
鞘氨醇-1-磷酸途径在人类妊娠组织中差异化激活
Magdaleena Naemi Mbadhi,Hideji Fujiwara,Ruth Gill et al.
Magdaleena Naemi Mbadhi et al.
Background: Dysregulated myometrial contractility contributes to obstetric complications. Sphingosine-1-phosphate (S1P), a bioactive lipid, modulates inflammation and smooth muscle contractility, including uterine contrac...
TS3 Asn347 corticosteroid-binding globulin (CBG) glycoform deficiency is associated with mortality in human septic shock [0.03%]
人重症感染性休克患者的TS3 Asn347皮质类固醇结合蛋白(CBG)糖链缺乏与病死率相关
Jessica H Lee,Zeynep Sumer-Bayraktar,R Louise Rushworth et al.
Jessica H Lee et al.
Context: Corticosteroid-binding globulin (CBG) deficiency is an independent predictor of intensive care unit (ICU) mortality in septic shock. CBG glycosylation at the Asn347 site affects neutrophil elastase cleavage susce...
Regulatory risk loci link disrupted androgen response to the pathophysiology of polycystic ovary syndrome [0.03%]
调控性风险基因位点链接雄激素反应受阻与多囊卵巢综合征病理生理学之间的联系
Jaya Srivastava,Ivan Ovcharenko
Jaya Srivastava
A major challenge in deciphering the complex genetic landscape of polycystic ovary syndrome (PCOS) lies in the limited understanding of how susceptibility loci drive molecular mechanisms across diverse phenotypes. To address this, we integr...
Glucose-dependent dynamics of glucagon, cortisol and adrenocorticotropic hormone before and after gastric bypass [0.03%]
胃旁路术前术后血糖依赖性的胰高糖素、皮质醇和促肾上腺皮质激素动态变化规律研究
Vasileios Chronopoulos,Maria C Kjellsson,Martin H Lundqvist
Vasileios Chronopoulos
Context: Roux-en-Y gastric bypass (RYGB) improves glucose homeostasis beyond weight loss, but the underlying mechanisms remain incompletely understood. Counter-regulatory hormones such as glucagon, ACTH, and cortisol are ...
Determining EDC exposure: direct analytical methods are essential for accurate analysis of human biospecimens [0.03%]
确定EDC暴露：准确分析人类生物标本的关键在于直接分析方法
Roy Gerona,Alia Sovereign,Deborah French et al.
Roy Gerona et al.
Purpose: Estimates of human exposure are a major component of chemical risk assessment. Studies of bisphenol A (BPA) have raised concern that exposure has been underestimated because the lack of standards for the measurem...
Characterization of adrenal masses in young adults at a tertiary care academic medical center [0.03%]
三级医疗学术中心年轻成年人肾上腺肿物的特征分析
Sarah Jacob,Malak Itani,Mark J Hoegger et al.
Sarah Jacob et al.
Context: Evidence on the etiology and function of adrenal masses in younger adults is scarce. Objective: This work aimed to characteriz...
Assessing the accuracy of thyroid nodule risk-stratification tools in Hispanic and non-Hispanic patients [0.03%]
评估甲状腺结节风险分层工具在西班牙裔和非西班牙裔患者中的准确性
Carine Tamamian,Clifford Jiajun He,Charles Choe et al.
Carine Tamamian et al.
Context: Ultrasound risk categories (thyroid imaging, reporting, and data systems, TI-RADS), fine-needle aspiration cytology (Bethesda), and molecular classifiers guide thyroid nodule management. However, these tools may ...