The sphingosine-1-phosphate pathway is differentially activated in human gestational tissues [0.03%]
鞘氨醇-1-磷酸途径在人类妊娠组织中差异化激活
Magdaleena Naemi Mbadhi,Hideji Fujiwara,Ruth Gill et al.
Magdaleena Naemi Mbadhi et al.
Background: Dysregulated myometrial contractility contributes to obstetric complications. Sphingosine-1-phosphate (S1P), a bioactive lipid, modulates inflammation and smooth muscle contractility, including uterine contrac...
TS3 Asn347 corticosteroid-binding globulin (CBG) glycoform deficiency is associated with mortality in human septic shock [0.03%]
人重症感染性休克患者的TS3 Asn347皮质类固醇结合蛋白(CBG)糖链缺乏与病死率相关
Jessica H Lee,Zeynep Sumer-Bayraktar,R Louise Rushworth et al.
Jessica H Lee et al.
Context: Corticosteroid-binding globulin (CBG) deficiency is an independent predictor of intensive care unit (ICU) mortality in septic shock. CBG glycosylation at the Asn347 site affects neutrophil elastase cleavage susce...
Regulatory risk loci link disrupted androgen response to the pathophysiology of polycystic ovary syndrome [0.03%]
调控性风险基因位点链接雄激素反应受阻与多囊卵巢综合征病理生理学之间的联系
Jaya Srivastava,Ivan Ovcharenko
Jaya Srivastava
A major challenge in deciphering the complex genetic landscape of polycystic ovary syndrome (PCOS) lies in the limited understanding of how susceptibility loci drive molecular mechanisms across diverse phenotypes. To address this, we integr...
Glucose-dependent dynamics of glucagon, cortisol and adrenocorticotropic hormone before and after gastric bypass [0.03%]
胃旁路术前术后血糖依赖性的胰高糖素、皮质醇和促肾上腺皮质激素动态变化规律研究
Vasileios Chronopoulos,Maria C Kjellsson,Martin H Lundqvist
Vasileios Chronopoulos
Context: Roux-en-Y gastric bypass (RYGB) improves glucose homeostasis beyond weight loss, but the underlying mechanisms remain incompletely understood. Counter-regulatory hormones such as glucagon, ACTH, and cortisol are ...
Determining EDC exposure: direct analytical methods are essential for accurate analysis of human biospecimens [0.03%]
确定EDC暴露：准确分析人类生物标本的关键在于直接分析方法
Roy Gerona,Alia Sovereign,Deborah French et al.
Roy Gerona et al.
Purpose: Estimates of human exposure are a major component of chemical risk assessment. Studies of bisphenol A (BPA) have raised concern that exposure has been underestimated because the lack of standards for the measurem...
Characterization of adrenal masses in young adults at a tertiary care academic medical center [0.03%]
三级医疗学术中心年轻成年人肾上腺肿物的特征分析
Sarah Jacob,Malak Itani,Mark J Hoegger et al.
Sarah Jacob et al.
Context: Evidence on the etiology and function of adrenal masses in younger adults is scarce. Objective: This work aimed to characteriz...
Assessing the accuracy of thyroid nodule risk-stratification tools in Hispanic and non-Hispanic patients [0.03%]
评估甲状腺结节风险分层工具在西班牙裔和非西班牙裔患者中的准确性
Carine Tamamian,Clifford Jiajun He,Charles Choe et al.
Carine Tamamian et al.
Context: Ultrasound risk categories (thyroid imaging, reporting, and data systems, TI-RADS), fine-needle aspiration cytology (Bethesda), and molecular classifiers guide thyroid nodule management. However, these tools may ...
Impact of idiopathic short stature on children's well-being: a nationwide study of short Danish children [0.03%]
特发性身材矮小对儿童健康的影响：一项关于丹麦矮小儿童的全国性研究
Anders Juul,Agnès Linglart,Michael Højby et al.
Anders Juul et al.
Context: It remains unclear whether idiopathic short stature (ISS), defined as a height below -2.0 SD score (SDS) without an identifiable cause, adversely affects psychosocial well-being. ...
Sex-specific disruption of estrogen receptor alpha (ERα) density in the social brain neural network by Firemaster 550 [0.03%]
助燃剂550对社交大脑神经网络中雌激素受体α密度的性别差异破坏作用
Jinyan Cao,Sagi Enicole A Gillera,William P Marinello et al.
Jinyan Cao et al.
We investigated how developmental exposure to the commercial flame retardant (FR) mixture Firemaster 550 (FM 550) affects estrogen receptor alpha (ERα) expression in key brain regions related to sociosexual behavior. We used prairie voles,...
A prospective cohort study of the factors associated with recurrence in young patients with thyroid cancer [0.03%]
年轻甲状腺癌患者的复发因素的前瞻性队列研究
Koki Shio,Satoshi Suzuki,Yoshiko Matsumoto et al.
Koki Shio et al.
Context: The incidence of thyroid cancer in young people has increased over the past 40 years. While prognosis is favorable, recurrence rates may reach 20%. We previously reported the pathological characteristics of 220 y...