CBG Montevideo: A Clinically Novel SERPINA6 Mutation Leading to Haploinsufficiency of Corticosteroid-binding Globulin [0.03%]
乌拉圭蒙得维的亚CBG病例：皮质类固醇结合球蛋白半定量缺乏导致的新类型的SERPINA6突变
Emily Jane Meyer,Lucía Spangenberg,Maria José Ramírez et al.
Emily Jane Meyer et al.
Corticosteroid-binding globulin (CBG) is the main transport protein for cortisol, binding up to 90% in a 1:1 ratio. CBG provides transport of cortisol within the circulation and targeted cortisol tissue delivery. Here, we describe the clini...
Practical Considerations for Initiating and Utilizing Flash Continuous Glucose Monitoring in Clinical Practice [0.03%]
临床实践中开始并利用动态血糖监测的实用考量
Carol H Wysham,Davida F Kruger
Carol H Wysham
Use of continuous glucose monitoring (CGM) has been shown to improve clinical outcomes in patients with type 1 diabetes (T1D) and type 2 diabetes (T2D), including improved glycemic control, better treatment adherence, and an increased under...
A Pilot Trial: Fish Oil and Metformin Effects on ApoB-Remnants and Triglycerides in Women With Polycystic Ovary Syndrome [0.03%]
鱼油和二甲双胍对多囊卵巢综合征妇女载脂蛋白B残粒和甘油三酯的影响：一项试点试验
Donna Vine,Ethan Proctor,Olivia Weaver et al.
Donna Vine et al.
Context: Women with polycystic ovary syndrome (PCOS) have increased incidence of atherogenic dyslipidemia and cardiovascular disease (CVD). Interventions targeting atherogenic dyslipidemia to reduce CVD risk are limited i...
Diagnosis and Management of Tumor-induced Osteomalacia: Perspectives From Clinical Experience [0.03%]
肿瘤引起的骨软化症的诊断与治疗：临床经验视角
Kathryn Dahir,María Belén Zanchetta,Irinel Stanciu et al.
Kathryn Dahir et al.
Purpose: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of abnormal phosphate and vitamin D metabolism caused by typically small endocrine tumors that secrete fibroblast growth factor 23 (FGF23). TIO i...
Juvenile Granulosa Cell Tumor as the Presenting Feature of McCune-Albright Syndrome [0.03%]
McCune-Albright综合征的首发表现为颗粒细胞瘤
Brynn E Marks,Ronan Sugrue,Wallace Bourgeois et al.
Brynn E Marks et al.
Introduction: GNAS mutations have been reported in both McCune-Albright syndrome (MAS) and juvenile granulosa cell tumors (JGCT) but have never been reported simultaneously in the same patient. ...
Genetic Diagnosis of Primary Adrenal Insufficiency in Children: A Paradigm Change [0.03%]
儿童原发性肾上腺皮质功能不全的基因诊断：一场变革
Madson Q Almeida
Madson Q Almeida
Response to the Letter to the Editor From Jialal and Sood: "New Cutoffs for the Biochemical Diagnosis of Adrenal Insufficiency After ACTH Stimulation Using Specific Cortisol Assays" [0.03%]
对Jialal和Sood致编辑部来信的答复：“使用特异性皮质醇测定法在ACTH刺激后诊断肾上腺功能不全的新临界值”
Bradley R Javorsky,Hershel Raff,Ty B Carroll et al.
Bradley R Javorsky et al.
An Approach to Nonsuppressed Testosterone in Transgender Women Receiving Gender-Affirming Feminizing Hormonal Therapy [0.03%]
跨性别女性接受性别肯定的女性激素治疗期间非抑制性睾酮的一例报告
Arvind Maheshwari,Todd Nippoldt,Caroline Davidge-Pitts
Arvind Maheshwari
Nonsuppressed levels of testosterone are seen in up to a quarter of transgender women on gender-affirming feminizing hormonal treatment. Multiple factors contribute to this situation, including patient, medication, laboratory, and organ-spe...
Aleksandra Sliwinska,Fatima Jalil,Lori De La Portilla et al.
Aleksandra Sliwinska et al.
Background: Giant prolactinomas are an exceedingly uncommon type of pituitary adenomas that usually occur in men, and cause extremely high prolactin levels and mass-related symptoms. Rarely, patients may experience neurol...
The Effect of Obstructive Sleep Apnea and Continuous Positive Airway Pressure Therapy on Skeletal Muscle Lipid Content in Obese and Nonobese Men [0.03%]
阻塞性睡眠呼吸暂停及持续气道正压治疗对肥胖和非肥胖男性骨骼肌脂质含量的影响
Alexander M Koenig,Ulrich Koehler,Olaf Hildebrandt et al.
Alexander M Koenig et al.
Obstructive sleep apnea (OSA), independently of obesity (OBS), predisposes to insulin resistance (IR) for largely unknown reasons. Because OSA-related intermittent hypoxia triggers lipolysis, overnight increases in circulating free fatty ac...