A Global Update on the Status of Prevention of Folic Acid-Preventable Spina Bifida and Anencephaly in Year 2024 [0.03%]
2024年全球叶酸可预防脊柱裂和无脑儿现状的更新报告
Vijaya Kancherla,Kaustubh Wagh,Helena Pachón
Vijaya Kancherla
Background: Spina bifida and anencephaly are major birth defects, and the majority of them can be prevented through maternal intake of folic acid (vitamin B9) during early pregnancy. We estimated the proportion of folic a...
Developmental Toxicity Evaluation of the Dietary Supplement Vinpocetine Using Mouse and Human 3D Gastruloids [0.03%]
使用小鼠和人类3D原肠胚体评估饮食补充剂长春花碱的发育毒性
Alexia Maki,Yusuke Marikawa
Alexia Maki
Background: Vinpocetine is marketed as a dietary supplement for cognitive enhancement, despite the absence of regulatory requirements for comprehensive toxicity testing. The FDA has issued a warning against vinpocetine us...
New Approach Methodologies and Open Access Tools Help Characterize Risks for DART, DNT, or Endocrine Effects From Exposure to Hallucinogens With Potential Pesticide Contaminants [0.03%]
新的方法学和开放访问工具有助于表征致幻剂暴露于潜在农药污染物后的DART、DNT或内分泌效应的风险属性
Marilyn H Silva
Marilyn H Silva
Background: Psilocybe mushrooms (psilocybin/psilocin [PSI/PSC]) and ayahuasca (N,N-dimethyltryptamine [DMT]) are hallucinogenic serotonergic agonists. Pregnant and lactating women are frequently omitted from clinical stud...
Potential Risk Factors for Total Anomalous Pulmonary Venous Return: National Birth Defects Prevention Study, 1997-2011 and the Birth Defects Study to Evaluate Pregnancy Exposures, 2014-2021 [0.03%]
1997-2011年国家出生缺陷预防研究和2014-2021年出生缺陷评估妊娠暴露研究中完全异常肺静脉回流的潜在风险因素
Eva M Williford,Jada M Scott,Jeffrey Dayton et al.
Eva M Williford et al.
Background: Total anomalous pulmonary venous return (TAPVR) is a rare heart defect in which the pulmonary veins do not connect to the left atrium, instead draining into the right atrium or directly into other venous syste...
Perinatal Development: Misunderstood Biology That Can Lead Hazard Assessment Astray [0.03%]
围产期发育：容易被误解的生物学知识及其在危害评估中的误导作用
John M DeSesso
John M DeSesso
Background: Gestation periods of rodents and humans differ dramatically. Due to their brief time in utero, rodent offspring develop faster than humans, but at birth they are considerably less developmentally mature than h...
María Paz Bidondo,Paloma Brun,Boris Groisman et al.
María Paz Bidondo et al.
Oropouche virus (OROV) is an arbovirus that has caused multiple epidemic outbreaks in several Latin American countries. In 2024, cases of possible vertical transmission with congenital microcephaly were reported, raising concerns about pote...
Ashley M Mudd,Bladimir J Ovando,George P Daston
Ashley M Mudd
Background: Fluoride has come under recent scrutiny regarding concerns over potential neurodevelopmental and endocrine-related toxicities, with recent reviews by the National Toxicology Program (NTP) and European Food Saf...
Prevalence of Multivitamin/Folic Acid Intake, Diabetes, and Other Risk Factors for Birth Defects Among Women in the United States, Pregnancy Risk Assessment Monitoring System, 2017-2022 [0.03%]
2017—2022年美国妊娠风险监测系统中维生素/叶酸摄入、糖尿病及其他出生缺陷危险因素的流行情况
Eugene C Wong,Michelle Koh,Lorraine F Yeung et al.
Eugene C Wong et al.
Background: Birth defects can cause significant morbidity and mortality. We examined the prevalence of maternal characteristics and risk factors associated with birth defects and examined their associations with prepregna...
Ontogeny of Placental FcRn Protein During Human and Animal Pregnancy to Inform Developmental Toxicity Testing [0.03%]
人和动物妊娠期间胎盘FcRn蛋白的发育过程对开发毒性检测的意义
Christopher J Bowman,William J Breslin,Connie Chen et al.
Christopher J Bowman et al.
Introduction: Species differences exist in Fc domain-containing molecule transfer/biodistribution to the embryo-fetus during pregnancy. Placentation was reviewed and placental neonatal Fc receptor (FcRn) quantitation in t...
How Epigenetics Bridges Genes and Environment: A Multiomics Evidence Chain in Congenital Diaphragmatic Hernia [0.03%]
表观遗传学如何连接基因与环境：先天性膈疝的多组学证据链
Yunshan Gao,Xian Zhu,Rutao Dai et al.
Yunshan Gao et al.
Background/objectives: Congenital diaphragmatic hernia (CDH) is a severe developmental anomaly with high etiological heterogeneity. Although numerous susceptibility genes have been identified, genetic factors alone fail t...