Targeting fatty acid metabolism in hepatic macrophages mitigates acetaminophen-induced liver injury and promotes regeneration in mice [0.03%]
靶向肝巨噬细胞脂肪酸代谢减轻小鼠乙酰氨基酚致肝脏损伤并促进其再生
Xiaoyong Jiang,Beng Wu,Liuyu Xie et al.
Xiaoyong Jiang et al.
Background: An overdose of acetaminophen (APAP) can cause severe liver injury and may even lead to death. However, the mechanisms that underlie APAP-induced liver injury (AILI) are not fully understood. The extensive live...
Nicotinamide riboside enhances liver regeneration via the MCART1/ASB3 axis in obesity-compromised rats [0.03%]
烟酰胺核糖通过MCART1/ASB3轴促进肥胖小鼠肝再生
Hongbo Wang,Hai Li,Yang Liu et al.
Hongbo Wang et al.
Background: Obesity impairs liver regeneration by promoting chronic inflammation and metabolic dysfunction, especially in conditions like non-alcoholic fatty liver disease. Portal vein embolization (PVE), used to stimulat...
Chip A Bowman
Chip A Bowman
Abbreviated gadoxetic acid-enhanced MRI versus ultrasonography for HCC surveillance in high-risk patients: A randomized trial protocol [0.03%]
高风险患者肝癌筛查缩略gadoxetic酸增强MRI与超声随机对照试验方案
Hyo Jung Park,Jonggi Choi,Dong Wook Kim et al.
Hyo Jung Park et al.
Background: Although ultrasonography (US) is widely recommended for HCC surveillance, its limited sensitivity for early-stage HCC remains a concern. Gadoxetic acid-enhanced abbreviated MRI (HBP-AMRI) has demonstrated high...
Erratum: HMOX1+ macrophages determine immunosuppressive microenvironment and immunotherapy efficacy in hepatocellular carcinoma [0.03%]
校正:HMOX1+巨噬细胞决定肝癌免疫微环境的抑制性和免疫治疗的效果
Yabing Du,Wenxin Xu,Zhenkun Liu et al.
Yabing Du et al.
Autoimmune liver diseases in Latin America: Current landscape and challenges [0.03%]
拉丁美洲的自身免疫性肝病：现状与挑战
Cláudia Alves Couto,Alejandra Villamil,Debora Raquel Benedita Terrabuio et al.
Cláudia Alves Couto et al.
Burden of primary sclerosing cholangitis in Sweden (2002-2020): Incidence, outcomes, healthcare utilization, and costs [0.03%]
瑞典(2002-2020年)原发性硬化性胆管炎的疾病负担：发病率、结果、医疗保健利用和成本
Annika Bergquist,Nandita Kachru,Martina Aldvén et al.
Annika Bergquist et al.
Background: There is limited real-world evidence on the economic burden associated with primary sclerosing cholangitis (PSC). This study evaluated the prevalence, incidence, baseline characteristics, long-term outcomes, h...
The alternative splicing landscape of hepatocellular carcinoma and its potential for HCC detection [0.03%]
肝癌的可变剪接谱及在肝癌检测中的应用潜力
Courtney E Hershberger,Noah J Daniels,William M Patterson et al.
Courtney E Hershberger et al.
Background: Pre-mRNA alternative splicing contributes to oncogenic gene expression in hepatocellular carcinoma (HCC), and some oncogenic isoforms escape the tumor into circulation. This study aimed to characterize the alt...
A novel cell-permeable LOXL2 inhibitor PAT-1251 potently suppresses biliary liver fibrosis via collagen crosslinking-dependent and -independent mechanisms [0.03%]
一种新型的细胞通透性LOXL2抑制剂PAT-1251通过胶原交联依赖性和非依赖性机制有力地抑制胆汁性肝纤维化
Ping An,Guangyan Wei,Pinzhu Huang et al.
Ping An et al.
Background: LOXL2 promotes fibrosis through extracellular collagen crosslinking and intracellular signaling mechanisms. Here, we studied the mode of action of a novel potent, cell-permeable LOXL2 inhibitor PAT-1251 on hep...
Retraction: Adverse effects of anti-COVID-19 drug candidates and alcohol on cellular stress responses of hepatocytes [0.03%]
撤稿：抗新冠肺炎药物候选药物和酒精对肝细胞细胞应激反应的不良影响
Atousa Khalatbari,Zahra Aghazadeh,Cheng Ji
Atousa Khalatbari