Refining surveillance of hepatocellular carcinoma in chronic hepatitis B through biomarker-based risk stratification [0.03%]
基于生物标志物的肝癌风险分层可改善慢性乙肝患者的监测体系
Tai-Chung Tseng,Shang-Chin Huang,Jia-Horng Kao
Tai-Chung Tseng
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with chronic hepatitis B (CHB) accounting for more than half of the cases. Regular surveillance, including abdominal ultrasonography with alpha-fe...
Camila Carvalho,Fulei Wuchu,Nicole Peterson et al.
Camila Carvalho et al.
Cholangiocarcinoma (CCA), a subset of biliary tract cancers, remains a therapeutically challenging malignancy with poor long-term survival despite recent advances in targeted therapies. Recent data suggest that IDH1-mutated CCA exhibits uni...
Improvement in health-related quality of life after treatment with resmetirom in patients with the spectrum of MASLD: From early MASH to MASH cirrhosis [0.03%]
用于治疗MASLD患者（从早期MASH到MASH肝硬化）的Resmetirom治疗后与健康相关的生活质量改善：来自REVERSE试验的事后分析
Zobair M Younossi,Fatema Nader,Dominic Labriola et al.
Zobair M Younossi et al.
Background: Resmetirom is approved for MASH F2-F3 fibrosis. Health-related quality of life (HRQL) was assessed in patients with MASH treated with resmetirom. ...
Reconsidering antiviral prophylaxis in HBsAg-negative, anti-HBc-positive patients treated with rituximab [0.03%]
HBsAg阴性、抗HBc阳性患者接受利妥昔单抗治疗的抗病毒预防再思考
George Papatheodoridis,Jessica Hwang
George Papatheodoridis
Hepatocellular carcinoma in Fontan-associated liver disease: Incidence, risk stratification, and surveillance implications [0.03%]
Fontan相关性肝病的肝细胞癌：发生率、风险分层和筛查意义
Hideki Onishi,Norihisa Toh,Kenji Baba et al.
Hideki Onishi et al.
Background: Hepatocellular carcinoma (HCC) is a serious complication of Fontan-associated liver disease (FALD). However, data on its incidence, risk factors, and outcomes in this rare population are limited. We aimed to a...
Crosstalk between SPP1+ macrophages and ITGA5+ fibroblasts promotes hepatocellular carcinoma metastasis [0.03%]
SPP1+巨噬细胞与ITGA5+成纤维细胞的串话促进肝细胞癌转移
Ting Tang,Yubo Li,Ni Xiyun et al.
Ting Tang et al.
Background: Hepatocellular carcinoma (HCC) develops from chronic inflammatory conditions to malignancy, with the immune microenvironment playing a significant role in this progression. However, the changes in the dynamic ...
Low anti-Mullerian hormone in reproductive age is associated with MASLD in midlife [0.03%]
生育年龄女性抗 Mullerian激素水平低与中年时期慢性肾脏病关系密切
Katherine M Cooper,Melissa Wellons,James G Terry et al.
Katherine M Cooper et al.
Background: Anti-Mullerian hormone (AMH) is produced by ovarian follicles and is clinically reflective of reproductive aging. AMH has been associated with the severity of steatohepatitis in those with known metabolic dysf...
Cyclic GMP-AMP synthase deficiency predisposes the liver to alcohol-induced cell death and ER stress [0.03%]
缺 cyclic GMP-AMP 合酶可使肝脏易受酒精引起的细胞死亡和内质网压力的影响
Mrigya Babuta,Aditi Ashish Datta,Marcelle de Carvalho Ribeiro et al.
Mrigya Babuta et al.
Background: Cyclic GMP-AMP synthase (cGAS) catalyzes the production of cGAMP, which activates the STING-IRF3 signaling pathway. Previous investigations indicated a role for STING-IRF3 in early alcohol-associated liver dis...
Validation of longitudinal biomarker screening algorithms for HCC detection in patients with cirrhosis [0.03%]
肝硬化患者纵向生物标志物筛查算法用于检测HCC的有效性评估
Amit G Singal,Qingchun Jin,Jorge Marrero et al.
Amit G Singal et al.
Background: Blood-based biomarker panels, including GALAD, have been proposed as an alternative to abdominal ultrasound for hepatocellular carcinoma (HCC) surveillance. Studies suggest longitudinal evaluation of biomarker...
Defining the Society of Pediatric Liver Transplantation (SPLIT) research agenda: A Delphi consensus project [0.03%]
儿童肝移植协会（SPLIT）研究议程的定义：德尔菲共识项目
Sharad I Wadhwani,Pooja Reddy Spector,Amy G Feldman et al.
Sharad I Wadhwani et al.
Background: Despite major advances in surgical and medical management, only one-third of pediatric liver transplant (LT) recipients remain morbidity-free at 10 years. The Society of Pediatric Liver Transplantation (SPLIT)...