Monocyte-derived IL-1β predicts and promotes HBsAg decline in chronic hepatitis B patients under nucleoside analogue therapy [0.03%]
单核细胞衍生的IL-1β预测并促进慢性乙型肝炎患者在口服核苷(酸)类似物治疗过程中的HBsAg下降
Satoshi Shigeno,Takahiro Kodama,Kazuhiro Murai et al.
Satoshi Shigeno et al.
Background: Although nucleos(t)ide analogs (NAs) suppress HBV replication, functional cure-defined by hepatitis B surface antigen (HBsAg) loss-is rarely achieved in chronic hepatitis B (CHB). Immune correlates of HBsAg de...
Development and validation of a disease-specific health-related quality of life questionnaire for alcohol-associated liver disease: The CLDQ-ALD [0.03%]
酒精相关性肝病特异性生命质量测量工具CLDQ-ALD的构建和验证
Zobair M Younossi,Maria Stepanova,Issah Younossi et al.
Zobair M Younossi et al.
Background: Accurate assessment of health-related quality of life (HRQL) is essential in clinical research and therapeutic trials in alcohol-associated liver disease (ALD). The study aimed to develop and validate an ALD-s...
Han Wang,Allan Tsung,Hongji Zhang
Han Wang
Neutrophil extracellular traps (NETs) are known for their propensity to expel decondensed chromatin embedded with inflammatory proteins, which can entrap and kill pathogens. The destructive role of NETs in sterile liver inflammation has als...
Reduced wait times for hepatology referrals in a prospective quality improvement initiative [0.03%]
前瞻性质量改进计划中肝病专科门诊预约等待时间缩短
Ofodile Joe-Uzuegbu,Yashasavi Sachar,Abdel Aziz Shaheen et al.
Ofodile Joe-Uzuegbu et al.
Background: Waitlist volumes for hepatology referrals in Calgary, Alberta, have increased with population growth and rising chronic liver disease [alcohol-related, metabolic dysfunction-associated steatotic liver disease,...
Epigenetic drug control of Clec4g/LSECtin expression reduces fibrosis burden in cirrhosis [0.03%]
表观遗传药物调控Clec4g/LSECtin表达减轻肝硬化纤维化负担
Enrique Ángel-Gomis,Isabel Gómez-Hurtado,Maite G Fernández-Barrena et al.
Enrique Ángel-Gomis et al.
Background: Liver and lymph node endothelial cell C-type lectin (LSECtin) loss in liver sinusoidal endothelial cells (LSECs) during cirrhosis favors hepatic pro-inflammatory T-cell infiltration. We characterize histone pr...
Midodrine versus placebo in patients with acute-on-chronic liver failure with ascites-A randomized trial (MIDAS trial) [0.03%]
急性肝衰竭并腹水患者使用米多君与安慰剂治疗的随机对照试验(MIDAS试验)
Anand V Kulkarni,Shantan Venishetty,Sridevi Prasanna et al.
Anand V Kulkarni et al.
Background: Ascites is common in patients with acute-on-chronic liver failure (ACLF) and can complicate the course of ACLF due to circulatory dysfunction and hemodynamic compromise. Oral midodrine has been variably report...
Randomized Controlled Trial
Hepatology communications. 2026 May 22;10(6):e0966. DOI:10.1097/HC9.0000000000000966 2026
Reply: Validation of MELD 3.0 in 2 centers from different continents [0.03%]
对来自不同洲的两中心使用MELD 3.0进行验证的回信
Nikki Duong,Daniel J Huynh,Newsha Nikzad et al.
Nikki Duong et al.
A tailored pain self-management intervention for patients with cirrhosis is acceptable and improves pain control [0.03%]
一套针对肝硬化患者的止痛自我管理干预措施能够提升止痛效果并被患者接受
Shari S Rogal,Angela D Phares,Marilyn Brach et al.
Shari S Rogal et al.
Background: Chronic pain is common and uniquely challenging to manage in people with cirrhosis. The purpose of this pilot study was to evaluate the feasibility and acceptability of a tailored pain self-management (PSM) in...
Secretion of the HBV small surface antigen is driven by an ER autophagic pathway [0.03%]
HBV小表面抗原的分泌由内质网自噬途径驱动
Hong Cao,Eugene Krueger,Jing Chen et al.
Hong Cao et al.
Chronic hepatitis B (CHB), a major global public health burden, is characterized by the presence of high circulating levels of non-infectious subviral particles (SVPs). These SVPs are mainly composed of small hepatitis B surface antigen (SH...
Effect of tiomolibdate choline on copper balance in patients with Wilson disease: An open-label phase 2 trial [0.03%]
一项开放标签2期试验：tiomolol胆碱对威尔森病患者铜平衡的影响
Aftab Ala,Thomas D Sandahl,Karl H Weiss et al.
Aftab Ala et al.
Background: Wilson disease (WD) is a rare disorder of copper (Cu) disposition. Tiomolibdate choline (TMC, bis-choline tetrathiomolybdate, ALXN1840), an oral Cu-binding agent, was investigated for the treatment of WD. The ...