PolyIC as an adjuvant outperforms anti-VEGF in combination with anti-PD-L1 therapy in mouse liver tumor models [0.03%]
聚乙二醇化OX40配体(PolyIC)可增强抗PD-L1的抗肿瘤疗效
Yichun Ji,Li-Chun Lu,Hao Zhuang et al.
Yichun Ji et al.
Background: Immune checkpoint inhibitors combined with antiangiogenic therapy have become the standard of care for advanced HCC, albeit with limited therapeutic benefit. Our previous studies demonstrated the immunomodulat...
Alcohol-induced KDM5B activation in hepatocytes drives pathogenic cell-cell communication, leading to loss of liver function [0.03%]
酒精诱导的肝细胞KDM5B活化驱动致病性细胞间通讯并导致肝功能丧失
Kruti Nataraj,Michael Schonfeld,Samson Mah et al.
Kruti Nataraj et al.
Background: Alcohol-associated liver disease (ALD) is a major cause of alcohol-associated mortality. Previously, we identified KDM5B as a sex-specific mediator of ALD development; however, the mechanism behind KDM5B-induc...
A randomized trial of ascorbic acid for the prevention of post-reperfusion syndrome during liver transplantation [0.03%]
维生素C预防肝移植再灌注时发生再灌注损伤的随机对照试验研究
Luis Gajate Martín,Inés de la Hoz,María Martín et al.
Luis Gajate Martín et al.
Background: Post-reperfusion syndrome (PRS) is a critical hemodynamic complication during liver transplantation, characterized by a significant drop in mean arterial pressure and associated with increased morbidity and mo...
Aramchol attenuates fibrosis in mouse models of biliary fibrosis and blocks the TGFβ-induced fibroinflammatory mediators in cholangiocytes [0.03%]
Aramchol可减轻胆管纤维化小鼠模型中的纤维化并阻止转化生长因子β诱导的胆管上皮细胞纤维炎症介质
Sayed Obaidullah Aseem,Jing Wang,Maleeha F Kalaiger et al.
Sayed Obaidullah Aseem et al.
Background: Cholestatic liver diseases, including primary sclerosing cholangitis, are characterized by biliary fibroinflammation. TGFβ-activated cholangiocytes release signals that recruit immune cells and activate myofi...
Outcome of hepatic resection for HCC in ideal and non-ideal candidates [0.03%]
理想的和非理想的肝癌患者手术切除的效果研究
Lorenzo Lani,Laura Bucci,Valentina Santi et al.
Lorenzo Lani et al.
Background: The Barcelona Clinic Liver Cancer staging system considers, among patients with HCC, "ideal candidates" (ICs) for hepatic resection (HR) those with a single lesion, normal bilirubin, and without clinically sig...
Integrating hepatology with addiction care for inpatients with alcohol use disorder reduces future liver-related events [0.03%]
将肝学与住院治疗酒精使用障碍的戒瘾疗法相结合可减少未来的肝脏相关事件
Paul George,Chantelle Marshall,Wei Zhang et al.
Paul George et al.
Background: Strategies to identify patients with early alcohol-associated liver disease (ALD), prior to the development of liver-related decompensated events, and promote alcohol therapy engagement in these patients are u...
Opioid use after adult liver transplantation: Incidence, high-risk use, and adverse events in a large US cohort [0.03%]
美国成人肝移植受者的阿片使用：大型队列中的发病率、高风险使用和不良事件
Sarah R Lieber,Olgert Bardhi,Yue Jiang et al.
Sarah R Lieber et al.
Background: Opioid use contributes to significant morbidity, posing specific risks to liver transplant recipients (LTRs). This study aimed to characterize outpatient opioid use before and after liver transplantation (LT) ...
Vanilla Xin Zhang,Yu-Man Tsui,Irene Oi-Lin Ng
Vanilla Xin Zhang
Erratum: BTLA deficiency promotes HSC activation and protects against hepatic ischemia-reperfusion injury [0.03%]
更正：BTLA缺乏促进造血干细胞活化并防止肝缺血再灌注损伤
Shen Xiaoyun,Mai Rongyun,Han Xiao et al.
Shen Xiaoyun et al.
Published Erratum
Hepatology communications. 2025 Jul 21;9(8):e0761. DOI:10.1097/HC9.0000000000000761 2025