Narrative review of the scientific and methodological explanations for 101 mechanisms of opioid tolerance [0.03%]
opioids耐受性的101种机制的科学和方法学解释的叙述性综述
Michael M Morgan,Erin N Bobeck
Michael M Morgan
Opioids such as morphine and fentanyl are widely prescribed treatments for pain. Unfortunately, opioid use is limited by side effects, dependence, and the development of tolerance with repeated use. A major goal of preclinical opioid resear...
Efficacy and safety of the Cav2.2 blocker Ziconotide in pain: a meta-analysis and systematic review [0.03%]
卡贝灵（Cav2.2阻滞剂齐考诺肽）镇痛的疗效和安全性：meta分析及系统评价
Javier Picañol,Aida Castellanos,Francesco Sartori et al.
Javier Picañol et al.
Chronic pain remains a significant clinical challenge, especially in refractory cases. Ziconotide, a selective Cav2.2 channel blocker, offers an intrathecal approach, but concerns about its safety, potential biases, and impact on opioid con...
Spatial transcriptomic alterations of the dorsal horn in dogs with neuropathic pain [0.03%]
神经病理性疼痛犬背角空间转录组改变
Tenna Remler Pedersen,Jørgen Steen Agerholm,Clare Rusbridge et al.
Tenna Remler Pedersen et al.
Introduction: Microglia and astrocytes are believed to play a central role in the pathogenesis of neuropathic pain (NeP). These glial cells are commonly identified by the expression of ionized calcium-binding adaptor mole...
Comparative study evaluating the efficacy of duloxetine, gabapentin, and lacosamide on oxaliplatin-induced peripheral neuropathy [0.03%]
度洛西汀、加巴喷丁和拉考沙胺对奥沙利铂诱发的外周神经病变疗效的比较研究
Sally Said Tantawy,Osama Mohamed Ibrahim,Sahar Mohamed El-Haggar et al.
Sally Said Tantawy et al.
Introduction: Peripheral neuropathic pain limits oxaliplatin use and negatively impacts patients' quality of life. Objectives: This stu...
Chronic pain and mortality risk among middle-age and older Japanese: the Shika town cohort study [0.03%]
慢性疼痛与中老年人的死亡风险：志摩镇队列研究
Jam Camara,Hiromasa Tsujiguchi,Akinori Hara et al.
Jam Camara et al.
Introduction: The relationship between chronic pain (CP) and mortality among the Japanese elderly population remains unclear due to limited literature. Ob...
Intact endogenous pain inhibition in complex regional pain syndrome type 1 [0.03%]
复杂区域疼痛综合征I型患者内源性镇痛功能完好无损
Florin Allmendinger,Laura Sirucek,Iara De Schoenmacker et al.
Florin Allmendinger et al.
Introduction: Impaired endogenous pain modulation is a common characteristic of various chronic pain conditions and may be a key mechanism underlying the development of chronic pain in complex regional pain syndrome (CRPS...
Ziyi Guo,Jianhua Qiu,Wei Meng et al.
Ziyi Guo et al.
Neuropathic pain is caused by a lesion or disease of the somatosensory (peripheral or central) nervous system. Most patients are associated with persistent or intermittent spontaneous pain. Intercellular interactions and molecular signaling...
B-cell lymphoma-extra large expression correlated with protein kinase RNA-like ER kinase and ubiquitination signals in the type 1 diabetes mouse model [0.03%]
B细胞淋巴瘤-X大型表达与蛋白质激酶RNA样内质网激酶和泛素信号在1型糖尿病小鼠模型中的关联研究
Yu-Yu Kan,Ying-Shuang Chang,Tzu-Ning Chao et al.
Yu-Yu Kan et al.
Introduction: Diabetes mellitus with pain sensation is referred to as diabetic painful neuropathy (DN). DN development results from endoplasmic reticulum (ER) stress, including the upregulation of ER stress signaling-rela...
Bayesian attenuation of offset analgesia filters out random disturbances in noxious stimuli [0.03%]
Bayesian方法减弱偏置镇痛以过滤有害刺激中的随机干扰现象
Ryota Ishikawa,Michihiro Osumi,Jun Izawa
Ryota Ishikawa
Introduction: Offset analgesia (OA), an endogenous pain inhibition after an abrupt decrease in noxious stimulation, provides a paradigm to study dynamic interaction between ascending and descending pain pathways. Previous...