The potent, indirect adenosine monophosphate- activated protein kinase activator R419 attenuates mitogen-activated protein kinase signaling, inhibits nociceptor excitability, and reduces pain hypersensitivity in mice [0.03%]
有效的非直接腺苷酸活化蛋白激酶激活剂R419可减弱丝裂原活化蛋白激酶信号传导，抑制伤害感受器兴奋性并降低小鼠疼痛过敏度
Galo L Mejia,Marina N Asiedu,Yasumichi Hitoshi et al.
Galo L Mejia et al.
There is a great need for new therapeutics for the treatment of pain. A possible avenue to development of such therapeutics is to interfere with signaling pathways engaged in peripheral nociceptors that cause these neurons to become hyperex...
Effect of osteopathic manipulative treatment on pain in palliative care patients: a randomized placebo-controlled clinical trial [0.03%]
整骨保健操对姑息治疗患者疼痛的影响：随机安慰剂对照临床试验
Introduction: Standard osteopathic manipulative therapy (OMT) is used as a supportive care for pain management in cancer patients. Objectives: ...