TCRγ constant usage tunes human γδ T cell antigen sensitivity, thymic programming, and peripheral function [0.03%]
TCRγ恒定区的使用调节人γδT细胞抗原敏感性、胸腺编程及外周功能
Mayuri Viswanathan,Caitlin D Castro,Augusta E Broughton et al.
Mayuri Viswanathan et al.
Activation in T cells through their antigen receptors has been closely tied to the strength of recognition of their cognate antigens, dictated by the variable complementarity-determining region loops. We show that, in the human gamma delta ...
Aldehyde and seek: Toxic aldehydes drive exhaustion in tumor-infiltrating T cells [0.03%]
甲醛与寻找：有毒的甲醛导致浸润在肿瘤中的T细胞衰竭
Cait A McAlindon,Rachael A Clark
Cait A McAlindon
Aldehydes accumulating in response to reduced fatty acid oxidation in tumor-infiltrating lymphocytes damage mitochondria and drive T cell exhaustion.
Single-cell profiling reveals diverse γδ T cell subsets in ulcerative colitis [0.03%]
单细胞分析揭示克罗恩病中多样的γδT细胞亚群
Lena S Mayer,Jakob Arnold,Felix Roettele et al.
Lena S Mayer et al.
γδ T cells maintain intestinal immune homeostasis, but their contributions to human ulcerative colitis (UC) are poorly understood. We characterized γδ T cells in intestinal biopsies obtained from patients with UC and healthy donors usin...
Ruimin Wang,Etienne Caron
Ruimin Wang
Melanoma cells evade immune detection by secreting MHC-peptide-loaded melanosomes that interact with and impair CD8+ TCRs.
Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells [0.03%]
共hesin介导的染色质组织控制树突状细胞的分化和功能
Nicholas M Adams,Aleksandra Galitsyna,Ioanna Tiniakou et al.
Nicholas M Adams et al.
The cohesin complex extrudes chromatin loops, stopping at sites bound by CCCTC-binding factor (CTCF) and organizing chromosomes into topologically associated domains, yet biological implications of this process remain obscure. We show that ...
James E Parkinson,Judith E Allen,Lucy H Jackson-Jones
James E Parkinson
The serous cavities are fluid-filled spaces that surround the lung, heart, and abdomen. One of their main functions is to provide protection and lubrication for their encapsulated organs. In addition to these physiological roles, the serous...
B cells drive CD4 T cell immunosenescence and age-associated health decline [0.03%]
B细胞驱动的CD4 T细胞免疫衰老及与年龄相关的健康下降
Saad Khan,Mainak Chakraborty,Fei Wu et al.
Saad Khan et al.
Dysregulation of the adaptive immune system is a key feature of aging and is associated with age-related chronic diseases and mortality. Here, we find that T cell aging, especially in the CD4 subset, is controlled by B cells. B cells contri...
Cross-species cellular mapping and humanization of Fcγ receptors to advance antibody modeling [0.03%]
跨物种细胞图谱绘制及Fcγ受体的人源化以促进抗体建模
Karel F A Van Damme,Dorine Sichien,Katrien Van der Borght et al.
Karel F A Van Damme et al.
Fc receptors mediate antibody effector functions. Immunoglobulin G (IgG), the predominant antibody in circulation and in clinical use, engages diverse Fc gamma (Fcγ) receptors differentially expressed across cell types. Here, we provide a ...
Patrick Fernandes Rodrigues,Shitong Wu,Tihana Trsan et al.
Patrick Fernandes Rodrigues et al.
How tolerogenic dendritic cell (DC) lineages are established to prevent inappropriate immune responses to commensals and food antigens remains unclear. We identify RORγt+ DCs in mice as a distinct lymphoid-derived lineage to safeguard inte...
Epidermal growth factor receptor controls sex differences in lung type 2 responses to inhaled allergen [0.03%]
表皮生长因子受体控制气道过敏原所致肺泡2型细胞的性别差异反应
Helen Stölting,April L Raftery,Simone A Walker et al.
Helen Stölting et al.
Hormonal disruptions are associated with poor asthma control in females, yet how these phenomena are linked remains unknown. Here, we investigated distinct allergen-induced immune responses between the sexes during maturation. By 6 weeks of...