ILC3s promote intestinal tuft cell hyperplasia and anthelmintic immunity through RANK signaling [0.03%]
肠固有层ILC3通过RANK信号促进簇细胞增殖和抗寄生虫免疫
Hongkai Xu,Yibo Wang,Wenyan Wang et al.
Hongkai Xu et al.
Helminth infections, particularly in developing countries, remain a notable health burden worldwide. Group 3 innate lymphoid cells (ILC3s) are enriched in the intestine and play a critical role in immunity against extracellular bacteria and...
Uptake of lipids from ascites drives NK cell metabolic dysfunction in ovarian cancer [0.03%]
卵巢癌患者腹水中脂质的吸收导致NK细胞代谢功能障碍
Karen Slattery,Cong-Hui Yao,Eimear Mylod et al.
Karen Slattery et al.
High-grade serous ovarian cancer (HGSOC) remains an urgent unmet clinical need, with more than 70% of patients presenting with metastatic disease. Many patients develop large volumes of ascites, which promotes metastasis and is associated w...
Chimeric autoantibody receptor T cells clonally eliminate B cells producing autoantibodies against IFN-γ [0.03%]
嵌合自身抗体受体T细胞克隆清除产生IFN-γ自身抗体的B细胞
Jhan-Jie Peng,Jing-Ya Ding,Yingxi Xu et al.
Jhan-Jie Peng et al.
Neutralizing anti-interferon-γ (IFN-γ) autoantibodies (nAIGAs) impair IFN-γ-mediated immunity, predisposing patients with nAIGAs to infection by nontuberculous mycobacteria, Talaromyces marneffei, and other intracellular pathogens. Curre...
Cell type-specific efferocytosis determines functional plasticity of alveolar macrophages [0.03%]
肺泡巨噬细胞胞吞作用决定其功能的可塑性
Julian Better,Mohammad Estiri,Michael Wetstein et al.
Julian Better et al.
Resolution of lung injuries is vital to maintain gas exchange, but there is an increased risk of secondary bacterial infections during this stage. Alveolar macrophages (AMs) are crucial to clear bacteria and control the resolution of inflam...
Distinct type I and II interferon responses direct cortical and medullary thymic epithelial cell development [0.03%]
I型和II型干扰素反应引导皮质胸腺上皮细胞和髓质胸腺上皮细胞的发育distinct type I and II interferon responses direct cortical and medullary thymic epithelial cell development
Abdulvasey Mohammed,Wenqing Wang,Martin Arreola et al.
Abdulvasey Mohammed et al.
Advances in genomics have redefined our understanding of thymic epithelial heterogeneity and architecture, yet signals driving thymic epithelial differentiation remain incompletely understood. Here, we elucidated pathways instructing human ...
Fibroblastic reticular cells form reactive myeloid cell niches in human lymph nodes [0.03%]
人淋巴结中的成纤维网状细胞形成反应性髓样细胞生态位
Mechthild Lütge,Lisa Kurz,Yves Stanossek et al.
Mechthild Lütge et al.
Lymph nodes play a key role in maintaining fluid balance in homeostatic and inflamed tissues and provide fibroblastic niche environments for optimal immune cell positioning and interaction. Here, we used single-cell and spatial transcriptom...
Amanda O Wong,Kodi S Ravichandran
Amanda O Wong
After lung injury, uptake of apoptotic neutrophils, but not epithelial cells, by alveolar macrophages prioritizes tissue repair over bacterial clearance (see related Research Article by Better et al.).
Jordan Polster,David R Martinez
Jordan Polster
The acute humoral immune response in patients with severe dengue can be extrafollicular, driven by a unique subset of CD4+ T cells.
Danielle R Jacobsen,Stephanie C Eisenbarth
Danielle R Jacobsen
Multiple APC subsets cooperate to induce regulatory T cells in the gut.