Inducible protein degradation reveals inflammation-dependent function of the Treg cell lineage-defining transcription factor Foxp3 [0.03%]
诱导型蛋白质降解揭示了Tregs细胞谱系决定性转录因子Foxp3在炎症依赖功能中的作用
Christina Jäger,Polina Dimitrova,Qiong Sun et al.
Christina Jäger et al.
Regulatory T cells (Treg cells) are immunosuppressive CD4 T cells defined by expression of the transcription factor Foxp3. Genetic loss-of-function mutations in Foxp3 cause lethal multiorgan autoimmune inflammation resulting from defects in...
Dissection of the immune landscape in psoriatic arthritis defines immunoproteasome up-regulation in treatment resistance [0.03%]
银屑病关节炎免疫特征的解析定义了治疗抵抗中的免疫蛋白酶体上调
Reut Tzemach,Chamutal Gur,Truong San Phan et al.
Reut Tzemach et al.
Despite substantial advancements in psoriatic arthritis (PsA) treatment modalities, a considerable proportion of patients continue to experience persistent joint inflammation, unresponsive to the armamentarium of disease-modifying antirheum...
Inflammatory mischief managed: How retinoic acid calms heart attacks at the (marrow) source [0.03%]
炎症作乱 Retinoic酸坐镇骨髓应对心脏病发作
Sahily Reyes-Esteves,Christopher A Hunter
Sahily Reyes-Esteves
Targeting vitamin A metabolism limits emergency hematopoiesis and promotes resolution of inflammation in myocardial infarction.
Jonathan S Maltzman
Jonathan S Maltzman
Why B cells are needed for optimal CD8 T cell memory.
An activating Stat1 mutant disrupts normal STAT4 innate lymphocyte programs during viral infection [0.03%]
STAT1激活突变体在病毒感染期间干扰正常的STAT4固有淋巴细胞程序
Rachael L Philips,Yi-Chu Liao,Colleen M Lau et al.
Rachael L Philips et al.
Interferonopathies drive autoimmunity but can also impair host responses to pathogens, including viral infections. To better understand viral susceptibility of patients with STAT1 gain-of-function (GOF) mutations, we generated conditional k...
Human LY9 governs CD4+ T cell IFN-γ immunity to Mycobacterium tuberculosis [0.03%]
人LY9通过调节CD4⁺T细胞中IFN-γ的产生来调控Mycobacteriumtuberculosis免疫反应
Masato Ogishi,Julia Puchan,Rui Yang et al.
Masato Ogishi et al.
CD4+ T cells are indispensable for optimal immunity to Mycobacterium tuberculosis (M.tb), a pathogen that triggers tuberculosis (TB) in humans. M.tb-specific human CD4+ T cells are known to polarize toward an interferon-γ (IFN-γ)-producin...
An engineered viral protein activates STAT5 to prevent T cell suppression [0.03%]
一种工程化病毒蛋白可通过活化STAT5来防止T细胞受到抑制
Yating Zheng,Zehui Gu,Claire E Shudde et al.
Yating Zheng et al.
T cell therapy efficacy can be compromised if cytokine-induced Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling is dysregulated or insufficient to sustain functionality. Here, we demonstrate that LCK kina...
A light-regulated circadian timer optimizes neutrophil bactericidal activity to boost daytime immunity [0.03%]
一种光控昼夜时钟调节器可优化中性粒细胞的杀菌活性以增强白天免疫反应
Lucia Yi Du,Pramuk Keerthisinghe,Leah Rolland et al.
Lucia Yi Du et al.
The immune response exhibits strong circadian rhythmicity, with enhanced bacterial clearance often synchronized with an organism's active phase. Despite providing the bulk of cellular antibacterial defense, the neutrophil clockwork is poorl...
C/EBPα activates Irf8 expression in myeloid progenitors at the +56-kb enhancer to initiate cDC1 development [0.03%]
C/EBPα在髓系前体细胞的+56 kb增强子处激活Irf8表达以启动cDC1发育
Jing Chen,Tian-Tian Liu,Feiya Ou et al.
Jing Chen et al.
Development of type 1 conventional dendritic cells (cDC1s) underlies the capacity to generate antiviral and antitumor immune responses. Here, we identify the basis for cDC1 development from its earliest progenitors, determining the hierarch...
Nicholas M Mroz,Pailin Chiaranunt,Anna V Molofsky et al.
Nicholas M Mroz et al.
Interactions between the nervous and immune systems are critical to healthy physiology and are altered in many human diseases. Many of the major players in type 2 immune responses, including type 2 lymphocytes and cytokines, mast cells, and...