Ailis Grieshaber,Kevin C O&#x;Connor
Ailis Grieshaber
Proteomic analysis shows that nearly all circulating human IgG4 undergoes Fab-arm exchange, creating a vast bispecific antibody repertoire.
Modulating AP-1 enables CAR T cells to establish an intratumoral stemlike reservoir and overcomes resistance to PD-1 blockade [0.03%]
调节AP-1能使CAR-T细胞在肿瘤微环境中建立类干祖细胞库并克服PD-1抑制剂的耐药性
Andrew J Snyder,Sarah M Garrison,Mitchell G Kluesner et al.
Andrew J Snyder et al.
Chimeric antigen receptor T (CAR T) cell therapy has shown limited synergy with immune checkpoint inhibitors, but the mechanisms underlying resistance remain unclear. Stemlike T cells coexpressing programmed cell death protein 1 (PD-1) and ...
Identification and characterization of dietary antigens in oral tolerance [0.03%]
饮食抗原的鉴定与表征在口服耐受中的作用
Jamie E Blum,Ryan Kong,E A Schulman et al.
Jamie E Blum et al.
Food antigens elicit immune tolerance through the action of intestinal regulatory T (Treg) cells. Unlike food allergens, the proteins that mediate tolerance are mostly undescribed. Here, we found that epitopes derived from seed storage prot...
Yoshiaki Yasumizu
Yoshiaki Yasumizu
EBV enables B cells to bypass death in the CNS, linking viral infection to autoimmune demyelination in multiple sclerosis.
Ahmad Yatim,Leila Youssefian,Aida Idani et al.
Ahmad Yatim et al.
The human integrin lymphocyte function-associated antigen 1 (LFA-1; αLβ2) is broadly expressed on leukocytes and involved in various intercellular adhesions. We report complete LFA-1 deficiency because of inherited αL (CD11a) deficiency ...
José L Fachi,Sarah de Oliveira,Tihana Trsan et al.
José L Fachi et al.
Platelet-derived growth factor D (PDGF-D) acts as a noncanonical ligand for human NKp44+ group 3 innate lymphoid cells (ILC3s). However, mice lack NKp44, raising the question of whether PDGF-D regulates murine ILC3s through a distinct pathw...
Jaewon Sim,Elizabeth O&#x;Guin,Chiho Sugimoto et al.
Jaewon Sim et al.
Women frequently experience longer-lasting pain than men, indicating delayed pain resolution, but the mechanisms underlying this sex difference remain unclear. Here, we show that interleukin-10+ (IL-10+) monocytes resolve inflammatory pain ...
Erratum for the Research Article "Two-dose priming immunization amplifies humoral immunity by synchronizing vaccine delivery with the germinal center response" [0.03%]
纠正：研究论文“两剂次疫苗免疫通过与生发中心反应同步化来放大体液免疫”中的错误
Published Erratum
Science immunology. 2026 Feb 13;11(116):eaef7375. DOI:10.1126/sciimmunol.aef7375 2026
Rapidly acquired HIV-1 neutralization breadth in a rhesus V2 apex knockin mouse model after a single bolus immunization [0.03%]
一种单次免疫后快速获得HIV-1广谱中和能力的恒河猴V2顶点敲入小鼠模型
Amrit Raj Ghosh,Rumi Habib,Nitesh Mishra et al.
Amrit Raj Ghosh et al.
Current immunization strategies to elicit broadly neutralizing antibodies (bnAbs) against HIV-1 generally propose complex, multiboost regimens. In rhesus macaques, simian-human immunodeficiency virus (SHIV) infection rapidly drives the deve...
Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development [0.03%]
环境-抗体共同进化揭示B细胞活化是HIV V2区广谱中和抗体发展的主要障碍
Rumi Habib,Ryan S Roark,Hui Li et al.
Rumi Habib et al.
Broadly neutralizing antibodies (bNAbs) are rarely elicited during HIV-1 infection. To identify obstacles to bNAb development, we longitudinally studied 122 rhesus macaques infected by 1 of 16 different simian-human immunodeficiency viruses...