CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity [0.03%]
通过保护肠道屏障的完整性来对抗炎症性和衰老的CD4T细胞治疗
Manuel M Gómez de Las Heras,Elisa Carrasco,Mario Pérez-Manrique et al.
Manuel M Gómez de Las Heras et al.
Healthy aging relies on a symbiotic host-microbiota relationship. The age-associated decline of the immune system can pose a threat to this delicate equilibrium. In this work, we investigated how the functional deterioration of T cells can ...
Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ-producing lymphocytes [0.03%]
棕色脂肪组织中的调节性T细胞通过限制产生干扰素-γ的淋巴细胞来保障产热作用
Nathan W Zammit,Ariana Vargas-Castillo,P Kent Langston et al.
Nathan W Zammit et al.
Whereas visceral adipose tissue (VAT) primarily stores excess energy, brown adipose tissue (BAT) dissipates it in a process termed nonshivering thermogenesis. Several key VAT features, particularly murine epidydimal VAT, are regulated by a ...
OTUD3 prevents ulcerative colitis by inhibiting microbiota-mediated STING activation [0.03%]
OTUD3通过抑制微生物介导的STING活化来预防溃疡性结肠炎
Bo Li,Taiki Sakaguchi,Haruka Tani et al.
Bo Li et al.
Ulcerative colitis (UC) develops through a complicated interaction between the host and microbiota. Intestinal fibroblasts are believed to play crucial roles in the pathogenesis of UC, but the influence of the host-microbiota interaction on...
Interactions between placental Hofbauer cells and L. monocytogenes change throughout gestation [0.03%]
胎盘霍夫鲍尔细胞与单核细胞增生性李斯特菌的相互作用在妊娠期间发生变化
Nagisa Yoshida,Anna Appios,Qian Li et al.
Nagisa Yoshida et al.
Hofbauer cells (HBCs) are extraembryonic macrophages generated de novo within the human placenta. In this study, we explored how the properties of HBCs change throughout gestation. Our analysis revealed transcriptomic differences between fi...
Tissue origin and virus specificity shape human CD8+ T cell cytotoxicity [0.03%]
组织来源和病毒特异性塑造人类CD8⁺ T细胞的细胞毒性
Julia Niessl,Thomas R Müller,Christian Constantz et al.
Julia Niessl et al.
CD8+ T cells are classically defined by cytotoxic activity, but it has remained unclear whether cytotoxic programs are compartmentalized across tissues and memory subsets. Here, we established a human organ donor cohort and found that expre...
Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors [0.03%]
多重模式定义肿瘤中耗竭性CD8 T细胞功能亚群的方法
Arja Ray,Molly Bassette,Kenneth H Hu et al.
Arja Ray et al.
Undescribed functional axes may intersect with the trajectory of T cell exhaustion (TEX) to contribute to the antitumoral functions of CD8 T cells. By leveraging fluorescent transcriptional reporting of the T cell activation marker Cd69, we...
Innate lymphoid cells originate from fetal liver-derived tissue-resident progenitors [0.03%]
固有淋巴样细胞起源于胎儿肝脏来源的组织驻留祖细胞
Xianwei Wang,Jiarui Li,Lucas Rebuffet et al.
Xianwei Wang et al.
Committed progenitors with innate lymphoid cell (ILC) developmental potential are present in the fetus and bone marrow (BM). However, how fetal and BM hematopoiesis temporally and spatially contribute to ILC pools remains unclear. Here, we ...
Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses [0.03%]
灵长类动物的内源性逆转录病毒元件外显子化和IL13RA1性别二态转录调控2型免疫反应
Tobias Plowman,Tom Hofland,Callum Hall et al.
Tobias Plowman et al.
Type 2 immunity is orchestrated by IL-4 and IL-13 signaling, initiated by binding to receptors that are specific to each cytokine or to the shared heterodimeric receptor comprising the IL-4Rα and IL-13Rα1 subunits. Here, we report that se...
Maria de Los Reyes Capilla Guerra,Gabriel K Griffin
Maria de Los Reyes Capilla Guerra
IL-10 plays a dual role in diffuse large B cell lymphoma progression and microenvironment, which could be leveraged for immunotherapy.
Tuft cells restrain intestinal type 2 immunity through the transcription factor Spi-B [0.03%]
转录因子Spi-B通过 tuft 细胞抑制肠型2免疫反应
Jiali Wang,Ruoxi Shen,Kunpeng Yang et al.
Jiali Wang et al.
Excessive type 2 immunity underlies various disease conditions, including allergies, yet the homeostatic mechanisms that limit type 2 responses are not fully understood. Here, we revealed that intestinal tuft cells, specialized epithelial c...