Divergent granulopoiesis at extramedullary sites safeguards antibacterial host defense [0.03%]
髓外粒细胞分化保证宿主抗细菌防御功能
Carlos Silvestre-Roig,Raphael Chevre,Merieme Farjia et al.
Carlos Silvestre-Roig et al.
Extramedullary organs such as the spleen can assume granulopoiesis as a supportive mechanism to cope with increased demands during persistent inflammation. However, the quantitative output of extramedullary granulopoiesis is limited, and wh...
Gene delivery of immunomodulatory cytokines to the lung preserves respiratory function during inflammatory challenge [0.03%]
基因传递免疫调节细胞因子保护气道阻力和肺顺应性免受炎症损伤
Ntombizodwa Makuyana,Laura Seldeslachts,Lauren Michiels et al.
Ntombizodwa Makuyana et al.
Respiratory infections that result in severe and life-threatening immune-mediated respiratory decline are a major public health issue. Controlling local respiratory immune reactions without the use of systemic immunosuppressants remains an ...
The autoantigen TRIM21 assembles proinflammatory immune complexes after lytic cell death [0.03%]
裂解性细胞死亡后的自体抗原TRIM21可形成促炎症免疫复合物
Esther L Jones Evans,Benjamin Demarco,Han Cai et al.
Esther L Jones Evans et al.
Sjögren's disease (SjD) causes localized and systemic inflammation and autoantibody production against intracellular proteins such as TRIM21/Ro52 (tripartite motif-containing protein 21). TRIM21, an E3 ubiquitin ligase, binds antibody Fc d...
Erratum for the Research Article "A noncanonical cytoplasmic role for BUB1 in restraining DNA damage-induced dsRNA accumulation and sensing within stress granules" [0.03%]
“BUB1具有非规范的细胞质功能以限制DNA损伤诱导的dsRNA积累和在应激颗粒内的感应”的研究论文的勘误表
Published Erratum
Science immunology. 2026 Apr 10;11(118):eaeh4448. DOI:10.1126/sciimmunol.aeh4448 2026
Single-cell TCR mapping reveals spatially coordinated T cell states in head and neck cancer [0.03%]
单细胞TCR鉴定揭示头颈肿瘤中空间协调的T细胞状态
Kelli A McCord,Emerald Kan,Sean Hyslop et al.
Kelli A McCord et al.
Current spatial T cell receptor (TCR) profiling approaches lack the resolution needed to link clonal identity, transcriptional state, and spatial positioning of individual T cells in the tumor microenvironment. Here, we introduce a spatial ...
The rise of spatial TCR profiling: Emerging technologies and open challenges [0.03%]
空间TCR谱系测序技术的兴起：新兴技术与开放性挑战
Yinglu Tang,Tao Wang
Yinglu Tang
High-definition spatial TCR profiling illuminates how clonal identity and T cell state are coordinated in the tumor microenvironment (see related Research Article by McCord et al.).
Intratumoral Treg cell ablation elicits NK cell-mediated control of CD8 T cell-resistant tumors [0.03%]
瘤内Treg细胞消融激发NK细胞介导的CD8 T细胞抵抗肿瘤控制作用
Chenyu Zhang,Charles Chien,Eglė Jurgaitytė et al.
Chenyu Zhang et al.
Cancer cells frequently lose major histocompatibility complex class I (MHC I) to evade CD8 T cell recognition. Natural killer (NK) cells are poised to target MHC I-deficient cancer cells, but MHC I loss alone is often insufficient to unleas...
Skull-pting meningeal immunity: Skull bone channels shape neonatal meningeal immune cell trafficking [0.03%]
颅骨塑形脑膜免疫：颅骨通道限制新生儿脑膜免疫细胞运输
Emma N Barnes,David R Martinez
Emma N Barnes
Osteoclast-mediated skull bone channel remodeling influences meningeal immune infiltration upon challenge.
Copper supports regulatory T cell energetic state to sustain peripheral immune tolerance [0.03%]
铜支持调节性T细胞的代谢状态以维持外周免疫耐受
Yage Zhang,Fan Shi,Haoyu Tang et al.
Yage Zhang et al.
Fine-tuning of energy metabolism is essential for the survival and suppressive function of regulatory T cells (Treg cells). Here, we show that Treg cells with a high energetic state display enhanced functional capacity. Using a screen of mi...
Claudins interact with LILRB immune inhibitory receptors to promote myeloid immunosuppression in cancer [0.03%]
Claudin蛋白通过与LILRB免疫抑制受体相互作用促进癌症中的髓系细胞免疫抑制
Xiaoye Liu,Ryan Huang,Zhiqiang Ku et al.
Xiaoye Liu et al.
The mechanisms underlying tumor cell-myeloid cell interactions in the tumor microenvironment (TME) remain unclear, and predictive biomarkers for patient response to myeloid checkpoint blockade are lacking. This study identified specific bin...