GPR25 promotes the formation of lung and liver tissue-resident memory CD8 T cells [0.03%]
GPR25促进肺和肝驻留记忆CD8+t细胞的形成
Han Feng,Sungjun Park,Jae Woo Shin et al.
Han Feng et al.
Tissue-resident memory CD8 T (TRM) cells provide critical antiviral and antitumor immunity, but the molecular pathways guiding their development are not fully defined. Here, we identify the G protein-coupled receptor GPR25, induced by TGF-...
An islet-resident macrophage antioxidant program preserves β cell physiology [0.03%]
一种海岛型巨噬细胞抗氧化程序可保持β细胞生理功能
Amélie Grosjean,Aude Jalon,Claire Leveau et al.
Amélie Grosjean et al.
Pancreatic islet-resident macrophages (IRMs) display an activated phenotype and contribute to islet development and remodeling, yet their origin, heterogeneity, and functional roles remain poorly understood. Using complementary fate-mapping...
CD21 primes extrafollicular differentiation of autoreactive B cells in a TLR7-driven lupus model [0.03%]
B细胞表面分子CD21在TLR7驱动的自身反应性B淋巴细胞分化和产生自身抗体中的作用机制研究
Danni Y Zhu,Daniel P Maurer,Carlos Castrillon et al.
Danni Y Zhu et al.
The extrafollicular (EF) B cell differentiation pathway has emerged as a prominent source of autoantibody-secreting cells (ASCs) in systemic lupus erythematosus (SLE). CD21loCD11c+ B cells are associated with aging, infection, and autoimmun...
Characterization of the mammalian prodefinitive angio-hematopoietic lineage [0.03%]
哺乳动物血管造血祖细胞的特征分析
Tomi Lazarov,Pierre-Louis Loyher,Hairu Yang et al.
Tomi Lazarov et al.
Mammalian hematopoietic cells arise from mesodermal progenitors in a close developmental relationship with endothelium and along three distinct cell lineages known as primitive, prodefinitive, and definitive hematopoiesis. However, the deve...
Kevin Champagne-Jorgensen,Jennifer L Gommerman
Kevin Champagne-Jorgensen
An MS twin study links ileal Lachnospiraceae to spontaneous CNS autoimmunity in mice receiving a human microbiome transplant.
TH17 cells converted into exTH17 cells sustain rheumatoid-like IL-17-independent inflammatory arthritis [0.03%]
转化而来的exTH17细胞能够引起IL-17非依赖性的类风湿关节炎样的炎症反应
Martina Zoccheddu,Kensuke Suga,Amara Seng et al.
Martina Zoccheddu et al.
T helper 17 (TH17) cells are found in the periphery and synovium of patients with rheumatoid arthritis (RA); however, IL-17-targeted interventions have limited efficacy in established RA. Inflammation can induce TH17 cell transdifferentiati...
B cells targeting parasites capture spatially linked antigens to secure T cell help [0.03%]
针对寄生虫的B细胞捕获空间上相互关联的抗原以获得T细胞帮助
Xin Gao,Hayley A McNamara,Jiwon Lee et al.
Xin Gao et al.
T cell-dependent antibody responses have been well studied in the context of small proteins and viruses. However, how B cells acquire and process antigens from large pathogens such as parasites remains poorly understood. Here, using Plasmod...
Kritika Dixit,David R Martinez
Kritika Dixit
Repeated dengue infections elicit broadly neutralizing antibodies that are protective against severe disease.
Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine [0.03%]
类干细胞组织驻留记忆T细胞控制肠道T细胞记忆的功能异质性和再激活现象
Kevin Man,Vinicius A Duarte da Silva,Nikita Potemkin et al.
Kevin Man et al.
Tissue-resident memory T (TRM) cells provide localized immunity against intracellular pathogens and cancer. Upon antigen reencounter, TRM cells differentiate into effector cells while also giving rise to another generation of memory cells. ...
RNA binding proteins control the G2-M checkpoint of the germinal center B cell [0.03%]
RNA结合蛋白控制生发中心B细胞G2/M检查点
Fiamma Salerno,Alex J Whale,Louise S Matheson et al.
Fiamma Salerno et al.
The germinal center (GC) reaction drives the production of high-affinity antibodies by iterative cycles of B cell somatic hypermutation, selection, and proliferation. How GC B cells undergo rapid cell division while maintaining genome stabi...