COVID-19 vaccine type controls stromal reprogramming in draining lymph nodes [0.03%]
新冠疫苗类型控制引流淋巴结间质重编程
Ruth Fair-Mäkelä,Pinja Thorén,Joni Näsiaho et al.
Ruth Fair-Mäkelä et al.
Lymph node (LN) stromal cells are critical regulators of immune reactions, yet their responses to different SARS-CoV-2 vaccines remain unexplored. Here, we immunized mice with clinically approved gene- and protein-based COVID-19 vaccines ta...
Stem-like and effector peripheral helper T cells comprise distinct subsets in rheumatoid arthritis [0.03%]
类干和效应外周辅助T细胞在类风湿关节炎中组成不同的亚群
Yuki Masuo,Akinori Murakami,Rinko Akamine et al.
Yuki Masuo et al.
Peripheral helper T (TPH) cells can play pathogenic roles in human autoimmune diseases. TPH cells are proposed to be the major B cell helpers in inflamed joints in rheumatoid arthritis (RA), but whether and how TPH cells are engaged in tiss...
Combined Flt3L and CD40 agonism restores dendritic cell-driven T cell immunity in pancreatic cancer [0.03%]
Flt3L和CD40激动剂联合恢复胰腺癌中的树突状细胞驱动的T细胞免疫
Graham D Hogg,Alyssa G Weinstein,Natalie L Kingston et al.
Graham D Hogg et al.
T cell-directed immunotherapies have largely failed to slow progression of pancreatic ductal adenocarcinoma (PDAC) because of poor tumor antigenicity and an immunosuppressive tumor microenvironment. We hypothesized that conventional dendrit...
Erratum for the Research Article "Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening" by L. U. B. Enk et al [0.03%]
L. U. B. Enk等人发表的研究文章“利用单细胞CRISPR筛选针对肾脏和肠道炎症的T细胞可塑性”的勘误表
Published Erratum
Science immunology. 2025 Aug 8;10(110):eaea6150. DOI:10.1126/sciimmunol.aea6150 2025
A noncanonical cytoplasmic role for BUB1 in restraining DNA damage-induced dsRNA accumulation and sensing within stress granules [0.03%]
BUB1非规范胞质功能限制DNA损伤诱导的dsRNA在应激颗粒内的积累和感应作用
Mengjie Hu,Dong Pan,Meng Jiao et al.
Mengjie Hu et al.
Budding uninhibited by benzimidazoles 1 (BUB1) is a nuclear serine/threonine protein kinase that ensures proper chromosome segregation before mitosis. We report that BUB1 plays an unexpected cytoplasmic role in restraining DNA damage-induce...
GM-CSF derived from alveolar type 2 cells promotes CD301b+ cDC2 generation and allergic airway inflammation [0.03%]
肺泡2型细胞衍生的GM-CSF促进CD301b+cDC2生成及过敏性气道炎症
Julia Gschwend,Antonie Lechner,Nikolaos D Sidiropoulos et al.
Julia Gschwend et al.
Pulmonary conventional dendritic cells (cDCs) are functionally and phenotypically heterogeneous antigen-presenting cells essential for orchestrating adaptive immune responses in the lung. Here, we define a cell-intrinsic role for granulocyt...
Immune signature clues are key to unlocking the mystery of clinical responses [0.03%]
免疫特征线索是解开临床反应谜团的关键
Robin R Kobylski,Laura A Solt
Robin R Kobylski
A gene signature predicts infection severity and all-cause mortality across risk factors modifiable with lifestyle changes and treatment.
Thomas T Xu,Shiv Pillai
Thomas T Xu
LAG-3 dampens CD4+ T cell activation by disrupting CDε-Lck condensates and is a therapeutic target in both cancer and autoimmunity.
Human CD4+ T cells regulate peripheral immune responses in rheumatoid arthritis via insulin-like growth factor-like family member 2 [0.03%]
人CD4+T细胞通过胰岛素样生长因子2型成员调节类风湿关节炎的外周免疫应答
Akinori Murakami,Rinko Akamine,Shiro Tanaka et al.
Akinori Murakami et al.
Human CD4+ T cells play a central role in the pathogenesis of autoimmune diseases, but their immunoregulatory mechanisms driving pathogenesis remain to be elucidated. We show that human T peripheral helper cells (TPH cells) regulate periphe...
Vagal TRPV1+ sensory neurons protect against influenza virus infection by regulating lung myeloid cell dynamics [0.03%]
迷走神经TRPV1阳性感觉神经元通过调节肺髓系细胞动力学抵抗流感病毒感染
Nicole Almanzar,Daping Yang,Jingya Xia et al.
Nicole Almanzar et al.
Influenza viruses are a major global cause of morbidity and mortality. Although vagal TRPV1+ nociceptive sensory neurons are known to mediate defenses against harmful agents, including pathogens, their function in lung antiviral defenses re...