In vivo reprogramming of cytotoxic effector CD8 T cells via fractalkine-conjugated mRNA-LNPs [0.03%]
通过fractalkine共价连接的mRNA-LNP在体内重新编程细胞毒性效应CD8T细胞
Angela R Corrigan,Shin Foong Ngiow,Maura Statzu et al.
Angela R Corrigan et al.
Selective in vivo reprogramming of cytotoxic effector CD8 T (Teff) cells holds tremendous promise as a therapeutic tool but has not yet been accomplished. Here, we demonstrate that fractalkine-conjugated mRNA lipid nanoparticles (mRNA-LNPs)...
Monocyte-derived macrophages drive neurological tissue damage through mitochondrial reactive oxygen species [0.03%]
单核细胞衍生的巨噬细胞通过线粒体活性氧驱动神经组织损伤
Juan Villar-Vesga,Donatella De Feo,Pauline Clément et al.
Juan Villar-Vesga et al.
Reactive oxygen species (ROS) produced by mononuclear phagocytes (MPs) are widely believed to drive tissue damage in multiple sclerosis (MS), yet the distinct roles of central nervous system (CNS)-resident versus CNS-invading MPs remain unc...
Mieke Metzemaekers,Ralph Stadhouders
Mieke Metzemaekers
Foxp3 exerts context-dependent chromatin-remodeling activity to establish key epigenetic programs that define the functional identity of regulatory T cells (see related Research Article by Wei et al.).
Isabella O Conway,Christopher A Hunter
Isabella O Conway
Targeting Treg cells to mitigate inflammation has been a challenge, but a parasite-derived cytokine may be key to engineering a Treg cell therapy.
Wenhui Li,Minmin Ge,Ziyi Luo et al.
Wenhui Li et al.
Metabolic perturbations in the tumor microenvironment profoundly compromise the stemlike properties and effector functions of CD8 T cells. Deciphering the metabolic circuitry that sustains T cell stemness is critical for reinvigorating tumo...
Foxp3 drives context-dependent epigenetic programs that define regulatory T cell molecular identity and function [0.03%]
FOXP3通过驱动上下文相关的表观遗传程序来定义调节性T细胞的分子身份和功能
Yuxi Wei,Hinako Ago,Ryuichi Murakami et al.
Yuxi Wei et al.
Regulatory T cells (Treg cells) express the master regulator, Foxp3, and display distinctive epigenetic landscapes ensuring Treg cell-specific gene expression and stable suppressive functions, yet Foxp3's contribution to this epigenetic ide...
Easton E Ford,Melissa L Smith
Easton E Ford
Antigen-specific B cell profiling uncovers key determinants of SARS-CoV-2 antibody breadth after infection and vaccination.
Erratum for the Research Article "The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/IL-33/type 2 innate immunity circuit" [0.03%]
“ Chemerin-CMKLR1轴系通过调控 beige脂肪细胞/IL-33/2型固有免疫回路限制产热”的研究论文勘误表
Published Erratum
Science immunology. 2026 Apr 24;11(118):eaeh5833. DOI:10.1126/sciimmunol.aeh5833 2026
Mitochondrial fission mediates an evolutionarily conserved antibacterial defense response [0.03%]
线粒体分裂介导一种进化上保守的抗菌防御反应
Ronan Kapetanovic,Syeda Farhana Afroz,James E B Curson et al.
Ronan Kapetanovic et al.
Animals engage pleiotropic immune defense mechanisms to survive infections. Here, we present a function for mitochondrial fission in host defense. Challenge of macrophages with Escherichia coli increased mitochondrial fission, with this res...
An adaptive cellular source of IL-17A and IL-17F is critical for the induction of experimental autoimmune encephalomyelitis [0.03%]
适应性细胞源的IL-17A和IL-17F对于实验性自身免疫性脑脊髓炎的诱发是必要的
Allen W Ho,Linglin Huang,Sumiti Sandhu et al.
Allen W Ho et al.
T helper 17 (TH17) cells are thought to play an important role in the pathogenesis of many autoimmune disorders, including multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). However, recent studies hav...