OTUD3 prevents ulcerative colitis by inhibiting microbiota-mediated STING activation [0.03%]
OTUD3通过抑制微生物介导的STING活化来预防溃疡性结肠炎
Bo Li,Taiki Sakaguchi,Haruka Tani et al.
Bo Li et al.
Ulcerative colitis (UC) develops through a complicated interaction between the host and microbiota. Intestinal fibroblasts are believed to play crucial roles in the pathogenesis of UC, but the influence of the host-microbiota interaction on...
Interactions between placental Hofbauer cells and L. monocytogenes change throughout gestation [0.03%]
胎盘霍夫鲍尔细胞与单核细胞增生性李斯特菌的相互作用在妊娠期间发生变化
Nagisa Yoshida,Anna Appios,Qian Li et al.
Nagisa Yoshida et al.
Hofbauer cells (HBCs) are extraembryonic macrophages generated de novo within the human placenta. In this study, we explored how the properties of HBCs change throughout gestation. Our analysis revealed transcriptomic differences between fi...
Tissue origin and virus specificity shape human CD8+ T cell cytotoxicity [0.03%]
组织来源和病毒特异性塑造人类CD8⁺ T细胞的细胞毒性
Julia Niessl,Thomas R Müller,Christian Constantz et al.
Julia Niessl et al.
CD8+ T cells are classically defined by cytotoxic activity, but it has remained unclear whether cytotoxic programs are compartmentalized across tissues and memory subsets. Here, we established a human organ donor cohort and found that expre...
Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors [0.03%]
多重模式定义肿瘤中耗竭性CD8 T细胞功能亚群的方法
Arja Ray,Molly Bassette,Kenneth H Hu et al.
Arja Ray et al.
Undescribed functional axes may intersect with the trajectory of T cell exhaustion (TEX) to contribute to the antitumoral functions of CD8 T cells. By leveraging fluorescent transcriptional reporting of the T cell activation marker Cd69, we...
Innate lymphoid cells originate from fetal liver-derived tissue-resident progenitors [0.03%]
固有淋巴样细胞起源于胎儿肝脏来源的组织驻留祖细胞
Xianwei Wang,Jiarui Li,Lucas Rebuffet et al.
Xianwei Wang et al.
Committed progenitors with innate lymphoid cell (ILC) developmental potential are present in the fetus and bone marrow (BM). However, how fetal and BM hematopoiesis temporally and spatially contribute to ILC pools remains unclear. Here, we ...
Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses [0.03%]
灵长类动物的内源性逆转录病毒元件外显子化和IL13RA1性别二态转录调控2型免疫反应
Tobias Plowman,Tom Hofland,Callum Hall et al.
Tobias Plowman et al.
Type 2 immunity is orchestrated by IL-4 and IL-13 signaling, initiated by binding to receptors that are specific to each cytokine or to the shared heterodimeric receptor comprising the IL-4Rα and IL-13Rα1 subunits. Here, we report that se...
Maria de Los Reyes Capilla Guerra,Gabriel K Griffin
Maria de Los Reyes Capilla Guerra
IL-10 plays a dual role in diffuse large B cell lymphoma progression and microenvironment, which could be leveraged for immunotherapy.
Tuft cells restrain intestinal type 2 immunity through the transcription factor Spi-B [0.03%]
转录因子Spi-B通过 tuft 细胞抑制肠型2免疫反应
Jiali Wang,Ruoxi Shen,Kunpeng Yang et al.
Jiali Wang et al.
Excessive type 2 immunity underlies various disease conditions, including allergies, yet the homeostatic mechanisms that limit type 2 responses are not fully understood. Here, we revealed that intestinal tuft cells, specialized epithelial c...
Surabhi Kumar,Kevin C O&#x;Connor
Surabhi Kumar
Fc-swapped variant monoclonal antibodies reveal new mechanisms underlying Mycobacterium tuberculosis restriction.
Radiotherapy enhances anticancer CD8 T cell responses by cGAMP transfer through LRRC8A/C volume-regulated anion channels [0.03%]
放射治疗通过LRRC8A/C容积调节阴离子通道转移cGAMP增强抗肿瘤CD8T细胞反应
Limin Cao,Li Wang,Zhihong Li et al.
Limin Cao et al.
The volume-regulated anion channels (VRACs) transport osmolytes, neurotransmitters, and cyclic GMP-AMP (cGAMP) across the cell membrane to regulate cell volume and host defense. We report that the leucine-rich repeat-containing 8A/C (LRRC8A...