Transient disruption of T cell help impairs germinal center dynamics and memory responses [0.03%]
T细胞帮助的暂时干扰损害生发中心的动力学和记忆反应
Louise M C Webb,Helena A Carslaw,Jessica James et al.
Louise M C Webb et al.
T follicular helper (TFH) cells are essential for germinal center (GC) formation and long-lived humoral immunity. Here, we used an Il21 fate mapping (Il21-fm) strategy to remove TFH cells from established GCs to disentangle their function f...
PTMA safeguards mitochondrial integrity to sustain metabolic function and antitumor activity of CD8 T cells [0.03%]
PTMA通过维护线粒体完整性来维持CD8 T细胞的代谢功能和抗肿瘤活性
Keling Huang,Xiaoxue Li,Wenhua Liang et al.
Keling Huang et al.
Immune checkpoint blockade (ICB) has transformed cancer treatment, yet its efficacy is often limited by the progressive exhaustion of tumor-reactive CD8 T cells. By analyzing transcriptomes of CD8 T cells from patients treated with ICB acro...
Intestinal epithelial TLR5 signaling promotes barrier-supportive macrophages [0.03%]
肠上皮TLR5信号促进屏障支持型巨噬细胞
Ming-Ting Tsai,Ryann Callaghan,Charles Ng et al.
Ming-Ting Tsai et al.
Intestinal macrophages are essential for epithelial barrier repair. In homeostasis, macrophages are continuously replenished by recruitment of circulating C-C chemokine receptor 2 (CCR2)+ monocytes into the intestinal lamina propria (LP), a...
Structural variation tunes apoptotic responses to drive immune escape in melanoma [0.03%]
结构变异调节凋亡反应以驱动黑色素瘤的免疫逃逸
Kyung Lock Kim,Gabriel K Griffin
Kyung Lock Kim
Copy-number variation reshapes apoptotic gene dosage to drive acquired immunotherapy resistance in melanoma.
Erratum for the Research Article "T cell receptor-triggered nuclear actin network formation drives CD4+ T cell effector functions" by N. Tsopoulidis et al [0.03%]
N. Tsopoulidis等人的研究文章《T细胞受体触发的核内肌动蛋白网络形成驱动CD4+ T细胞效应功能》的勘误公告
Published Erratum
Science immunology. 2026 Jan 9;11(115):eaee6626. DOI:10.1126/sciimmunol.aee6626 2026
Danyel Lee,Krishnamurthy Malathi,Tsubasa Okano et al.
Danyel Lee et al.
The 2'-5' oligoadenylate synthetases (OASs) are type I interferon-inducible enzymes that, with ribonuclease L (RNase L), have been studied in the context of their coupled action as antiviral effectors. RNase L degrades host and viral ssRNA,...
Mycobacterial α-glucans hijack dectin-1 to facilitate intracellular bacterial survival [0.03%]
分枝杆菌α-葡聚糖劫持dectin-1以促进细菌胞内存活
Shota Torigoe,Sumayah Salie,Roanne Keeton et al.
Shota Torigoe et al.
Mycobacteria have a cell envelope that can act as a shield against host defense. This study shows that mycobacteria survive in host macrophages by targeting the innate host receptor dectin-1 through a noncanonical ligand. Compared with wild...
Segmented filamentous bacteria reprogramming of alveolar macrophages limits postinfluenza bacterial pneumonia [0.03%]
分段丝状细菌介导的肺泡巨噬细胞重编程限制了流感后继发性细菌肺炎的发展
Vu L Ngo,Carolin M Lieber,Hirohito Abo et al.
Vu L Ngo et al.
Respiratory viral infection induces depletion and dysfunction of alveolar macrophages (AMs), resulting in high-susceptibility to life-threatening bacterial pneumonia. Colonization of the intestine by segmented filamentous bacteria (SFB) rep...
DNA-damaging chemotherapy reshapes cardiac-resident macrophage composition and function [0.03%]
细胞毒性化疗重塑心脏巨噬细胞组成和功能
Ruijun He,Farid F Kadyrov,Andrew L Koenig et al.
Ruijun He et al.
Heart failure and ischemic heart disease represent prevalent causes of death among cancer survivors. Despite extensive use of conventional chemotherapies, a limited understanding of how these agents affect the cardiac immune landscape exist...
Pathogenic IgE-fated memory B cell responses retain functional plasticity [0.03%]
致病性IgE命运决定的记忆B细胞反应保持功能可塑性
Kelly Bruton,Allyssa Phelps,Atai Ariaz et al.
Kelly Bruton et al.
Long-lived immunoglobulin E (IgE) responses against innocuous environmental and dietary antigens (Ags) are maintained by an IgG1-dominant memory B cell (MBC) compartment primed for interleukin-4 (IL-4) responsiveness. The plasticity of the ...