T-B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity [0.03%]
T-B细胞在异位淋巴滤泡中合作传播中枢神经系统自身免疫反应
Anna Kolz,Clara de la Rosa,Isabel J Syma et al.
Anna Kolz et al.
Meningeal ectopic lymphoid follicle (eLF)-like structures have been described in multiple sclerosis, but their role in central nervous system (CNS) autoimmunity is unclear. Here, we used a T helper 17 (TH17) adoptive transfer experimental a...
Clone tracking through repeated malaria identifies high-fidelity memory CD4 T cell responses [0.03%]
克隆跟踪通过重复疟疾识别高保真度记忆CD4 T细胞反应
Jason Nideffer,Florian Bach,Felistas Nankya et al.
Jason Nideffer et al.
Few studies have tracked human CD4+ T cell clones through repeated infections. We used longitudinal single-cell RNA and T cell receptor (TCR) tracking to study the functional stability and memory potential of CD4+ T cell clonotypes during r...
CCR8+ decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy [0.03%]
CCR8+蜕膜调节性T细胞在早期妊娠期间维持母胎免疫耐受
Zhuqing Li,Pinxin Si,Tingting Meng et al.
Zhuqing Li et al.
Regulatory T (Treg) cells play a vital role in maintaining maternal immune tolerance to the semiallogeneic fetus during pregnancy. Treg cell population heterogeneity and tissue-specific functions in the human decidua remain largely unknown....
Endothelial-driven TGFβ signaling supports lung interstitial macrophage development from monocytes [0.03%]
内皮细胞驱动的TGFβ信号支持单核细胞向肺间质巨噬细胞的发展
Wen Peng,Domien Vanneste,David Bejarano et al.
Wen Peng et al.
Lung interstitial macrophages (IMs) are monocyte-derived parenchymal macrophages whose tissue-supportive functions remain unclear. Despite progress in understanding lung IM diversity and transcriptional regulation, the signals driving their...
Erratum for the Research Article "Anti-immune complex antibodies are elicited during repeated immunization with HIV Env immunogens" by S. Brown et al [0.03%]
S. Brown等作者关于“重复使用HIVEnv免疫原进行免疫时会产生抗免疫复合物抗体”的研究文章勘误表
Published Erratum
Science immunology. 2025 Apr 11;10(106):eadx6798. DOI:10.1126/sciimmunol.adx6798 2025
Foxo1 regulates intestinal tissue-resident memory CD8 T cell biology in an anatomic compartment- and context-specific manner [0.03%]
Foxo1以解剖间隔和背景特异性的方式调节肠组织驻留记忆CD8 T细胞的生物学特性
Paul Hsu,Eunice J Choi,William H Wong et al.
Paul Hsu et al.
Tissue-resident memory CD8 T (TRM) cells serve as a front-line defense against microbial pathogens in barrier and mucosal tissues. Accurately predicting the roles of tissue-specific transcription factors (TFs) that regulate TRM biology rema...
Bcl11a maintains hematopoietic stem cell function but accelerates inflammation-driven exhaustion during aging [0.03%]
Bcl11a既维持造血干细胞功能又可在衰老期间加速炎症引起的耗竭反应
Jing Wang,Linlin Zhang,Xinyu Cui et al.
Jing Wang et al.
Preserving hematopoietic stem cell (HSC) functionality is essential for maintaining healthy blood and the immune system throughout life. HSC function declines with age; however, the underlying mechanisms are not fully understood. Using an i...
Psychological stress increases skin infection through the action of TGFβ to suppress immune-acting fibroblasts [0.03%]
心理压力通过TGFβ的作用抑制免疫作用成纤维细胞从而增加皮肤感染的可能性
Hung Chan,Fengwu Li,Tatsuya Dokoshi et al.
Hung Chan et al.
Infections after psychological stress are a major health care problem. Single-cell transcriptomics and lipidomic profiling in a mouse model of stress show that dermal fibroblasts undergoing adipogenesis have defective responses to Staphyloc...
Luck gone cold: A trifecta of B cell mutations associates with cryoglobulinemia [0.03%]
luck gone cold: A trifecta of B cell mutations associates with cryoglobulinemia
Kangzhi Chen,Kevin C O&#x;Connor
Kangzhi Chen
Triple somatic mutations in autoreactive B cells contribute to virus-associated autoimmune disease.
Skin damage signals mediate allergic sensitization to spatially unlinked antigen [0.03%]
皮肤损伤信号介导与空间位置不相关的抗原的过敏致敏化作用
Daniel A Waizman,Isabela Brown-Soler,Anjelica L Martin et al.
Daniel A Waizman et al.
Our current understanding of immunity to pathogens suggests that anatomic coupling of antigens with danger signals is a required feature for the formation of immune memory. However, in the context of pathogen-independent inflammation, the s...