Seth Thomas Scanlon
Seth Thomas Scanlon
Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes [0.03%]
人1型糖尿病胰淋巴结和脾的基因表达和染色质可及性联合分析
Maryam Abedi,Priyadarshini Rai,Yeqiao Zhou et al.
Maryam Abedi et al.
Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing β cells in the pancreas. While current therapies focus on managing the disease, a deeper understanding of the underlying molecular mechani...
GPR25 promotes the formation of lung and liver tissue-resident memory CD8 T cells [0.03%]
GPR25促进肺和肝驻留记忆CD8+t细胞的形成
Han Feng,Sungjun Park,Jae Woo Shin et al.
Han Feng et al.
Tissue-resident memory CD8 T (TRM) cells provide critical antiviral and antitumor immunity, but the molecular pathways guiding their development are not fully defined. Here, we identify the G protein-coupled receptor GPR25, induced by TGF-...
An islet-resident macrophage antioxidant program preserves β cell physiology [0.03%]
一种海岛型巨噬细胞抗氧化程序可保持β细胞生理功能
Amélie Grosjean,Aude Jalon,Claire Leveau et al.
Amélie Grosjean et al.
Pancreatic islet-resident macrophages (IRMs) display an activated phenotype and contribute to islet development and remodeling, yet their origin, heterogeneity, and functional roles remain poorly understood. Using complementary fate-mapping...
CD21 primes extrafollicular differentiation of autoreactive B cells in a TLR7-driven lupus model [0.03%]
B细胞表面分子CD21在TLR7驱动的自身反应性B淋巴细胞分化和产生自身抗体中的作用机制研究
Danni Y Zhu,Daniel P Maurer,Carlos Castrillon et al.
Danni Y Zhu et al.
The extrafollicular (EF) B cell differentiation pathway has emerged as a prominent source of autoantibody-secreting cells (ASCs) in systemic lupus erythematosus (SLE). CD21loCD11c+ B cells are associated with aging, infection, and autoimmun...
Characterization of the mammalian prodefinitive angio-hematopoietic lineage [0.03%]
哺乳动物血管造血祖细胞的特征分析
Tomi Lazarov,Pierre-Louis Loyher,Hairu Yang et al.
Tomi Lazarov et al.
Mammalian hematopoietic cells arise from mesodermal progenitors in a close developmental relationship with endothelium and along three distinct cell lineages known as primitive, prodefinitive, and definitive hematopoiesis. However, the deve...
Kevin Champagne-Jorgensen,Jennifer L Gommerman
Kevin Champagne-Jorgensen
An MS twin study links ileal Lachnospiraceae to spontaneous CNS autoimmunity in mice receiving a human microbiome transplant.
TH17 cells converted into exTH17 cells sustain rheumatoid-like IL-17-independent inflammatory arthritis [0.03%]
转化而来的exTH17细胞能够引起IL-17非依赖性的类风湿关节炎样的炎症反应
Martina Zoccheddu,Kensuke Suga,Amara Seng et al.
Martina Zoccheddu et al.
T helper 17 (TH17) cells are found in the periphery and synovium of patients with rheumatoid arthritis (RA); however, IL-17-targeted interventions have limited efficacy in established RA. Inflammation can induce TH17 cell transdifferentiati...
B cells targeting parasites capture spatially linked antigens to secure T cell help [0.03%]
针对寄生虫的B细胞捕获空间上相互关联的抗原以获得T细胞帮助
Xin Gao,Hayley A McNamara,Jiwon Lee et al.
Xin Gao et al.
T cell-dependent antibody responses have been well studied in the context of small proteins and viruses. However, how B cells acquire and process antigens from large pathogens such as parasites remains poorly understood. Here, using Plasmod...
Kritika Dixit,David R Martinez
Kritika Dixit
Repeated dengue infections elicit broadly neutralizing antibodies that are protective against severe disease.