Jaewon Sim,Elizabeth O&#x;Guin,Chiho Sugimoto et al.
Jaewon Sim et al.
Women frequently experience longer-lasting pain than men, indicating delayed pain resolution, but the mechanisms underlying this sex difference remain unclear. Here, we show that interleukin-10+ (IL-10+) monocytes resolve inflammatory pain ...
Erratum for the Research Article "Two-dose priming immunization amplifies humoral immunity by synchronizing vaccine delivery with the germinal center response" [0.03%]
纠正：研究论文“两剂次疫苗免疫通过与生发中心反应同步化来放大体液免疫”中的错误
Published Erratum
Science immunology. 2026 Feb 13;11(116):eaef7375. DOI:10.1126/sciimmunol.aef7375 2026
Rapidly acquired HIV-1 neutralization breadth in a rhesus V2 apex knockin mouse model after a single bolus immunization [0.03%]
一种单次免疫后快速获得HIV-1广谱中和能力的恒河猴V2顶点敲入小鼠模型
Amrit Raj Ghosh,Rumi Habib,Nitesh Mishra et al.
Amrit Raj Ghosh et al.
Current immunization strategies to elicit broadly neutralizing antibodies (bnAbs) against HIV-1 generally propose complex, multiboost regimens. In rhesus macaques, simian-human immunodeficiency virus (SHIV) infection rapidly drives the deve...
Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development [0.03%]
环境-抗体共同进化揭示B细胞活化是HIV V2区广谱中和抗体发展的主要障碍
Rumi Habib,Ryan S Roark,Hui Li et al.
Rumi Habib et al.
Broadly neutralizing antibodies (bNAbs) are rarely elicited during HIV-1 infection. To identify obstacles to bNAb development, we longitudinally studied 122 rhesus macaques infected by 1 of 16 different simian-human immunodeficiency viruses...
TCRγ constant usage tunes human γδ T cell antigen sensitivity, thymic programming, and peripheral function [0.03%]
TCRγ恒定区的使用调节人γδT细胞抗原敏感性、胸腺编程及外周功能
Mayuri Viswanathan,Caitlin D Castro,Augusta E Broughton et al.
Mayuri Viswanathan et al.
Activation in T cells through their antigen receptors has been closely tied to the strength of recognition of their cognate antigens, dictated by the variable complementarity-determining region loops. We show that, in the human gamma delta ...
Aldehyde and seek: Toxic aldehydes drive exhaustion in tumor-infiltrating T cells [0.03%]
甲醛与寻找：有毒的甲醛导致浸润在肿瘤中的T细胞衰竭
Cait A McAlindon,Rachael A Clark
Cait A McAlindon
Aldehydes accumulating in response to reduced fatty acid oxidation in tumor-infiltrating lymphocytes damage mitochondria and drive T cell exhaustion.
Single-cell profiling reveals diverse γδ T cell subsets in ulcerative colitis [0.03%]
单细胞分析揭示克罗恩病中多样的γδT细胞亚群
Lena S Mayer,Jakob Arnold,Felix Roettele et al.
Lena S Mayer et al.
γδ T cells maintain intestinal immune homeostasis, but their contributions to human ulcerative colitis (UC) are poorly understood. We characterized γδ T cells in intestinal biopsies obtained from patients with UC and healthy donors usin...
Ruimin Wang,Etienne Caron
Ruimin Wang
Melanoma cells evade immune detection by secreting MHC-peptide-loaded melanosomes that interact with and impair CD8+ TCRs.
Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells [0.03%]
共hesin介导的染色质组织控制树突状细胞的分化和功能
Nicholas M Adams,Aleksandra Galitsyna,Ioanna Tiniakou et al.
Nicholas M Adams et al.
The cohesin complex extrudes chromatin loops, stopping at sites bound by CCCTC-binding factor (CTCF) and organizing chromosomes into topologically associated domains, yet biological implications of this process remain obscure. We show that ...
James E Parkinson,Judith E Allen,Lucy H Jackson-Jones
James E Parkinson
The serous cavities are fluid-filled spaces that surround the lung, heart, and abdomen. One of their main functions is to provide protection and lubrication for their encapsulated organs. In addition to these physiological roles, the serous...