The Association of PTSD Symptom Severity with Localized Hippocampus and Amygdala Abnormalities [0.03%]
PTSD症状严重程度与海马和杏仁核局部异常的相关性研究
Teddy J Akiki,Christopher L Averill,Kristen M Wrocklage et al.
Teddy J Akiki et al.
Background: The hippocampus and amygdala have been repeatedly implicated in the psychopathology of posttraumatic stress disorder (PTSD). While numerous structural neuroimaging studies examined these two structures in PTSD...
Chadi G Abdallah,Paul Geha
Chadi G Abdallah
Pain and stress share significant conceptual and physiological overlaps. Both phenomena challenge the body's homeostasis and necessitate decision-making to help animals adapt to their environment. In addition, chronic stress and chronic pai...
Laura E Kwako,George F Koob
Laura E Kwako
Addiction has been conceptualized as a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that worsens over time and involves allostatic changes in hedonic function via changes in the brain rewa...
Rapid Acting Antidepressants in Chronic Stress Models: Molecular and Cellular Mechanisms [0.03%]
慢性应激模型中快速抗抑郁药物的作用机制研究分子与细胞水平上的探索
Brendan D Hare,Sriparna Ghosal,Ronald S Duman
Brendan D Hare
Stress-associated disorders, including depression and anxiety, impact nearly 20% of individuals in the United States. The social, health, and economic burden imposed by stress-associated disorders requires in depth research efforts to ident...
Oxytocin and Stress-related Disorders: Neurobiological Mechanisms and Treatment Opportunities [0.03%]
催产素与应激相关障碍：神经生物学机制和治疗机会
Lauren M Sippel,Casey E Allington,Robert H Pietrzak et al.
Lauren M Sippel et al.
Novel pharmacotherapies that improve outcomes for individuals with stress-related psychiatric disorders are needed. The neurohormone oxytocin (OT) is a promising candidate given its influence on the social-emotional brain. In this review, w...
Shariful A Syed,Charles B Nemeroff
Shariful A Syed
Early life stress has been shown to exert profound short- and long-term effects on human physiology both in the central nervous system and peripherally. Early life stress has demonstrated clear association with many psychiatric disorders in...
Effects of Acute Confinement Stress-induced Hypothalamic-Pituitary Adrenal Axis Activation and Concomitant Peripheral and Central Transforming Growth Factor-β1 Measures in Nonhuman Primates [0.03%]
非人灵长类动物急性禁闭压力引起的下丘脑-垂体-肾上腺轴激活及其伴随的外周和中枢转化生长因子-β1测量的影响
Jeremy D Coplan,Srinath Gopinath,Chadi G Abdallah et al.
Jeremy D Coplan et al.
Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine with anti-inflammatory, immunosuppressive and neuroprotective properties. The hypothalamic-pituitary-adrenal (HPA) axis and immune system exert bidirectional influences ...