Preclinical and Clinical Evidence of DNA Methylation Changes in Response to Trauma and Chronic Stress [0.03%]
创伤和慢性压力下DNA甲基化变化的临床前和临床证据
Natalie Matosin,Cristiana Cruceanu,Elisabeth B Binder
Natalie Matosin
Exposure to chronic stress, either repeated severe acute or moderate sustained stress, is one of the strongest risk factors for the development of psychopathologies such as post-traumatic stress disorder and depression. Chronic stress is li...
Increased Neuronal DNA/RNA Oxidation in the Frontal Cortex of Mice Subjected to Unpredictable Chronic Mild Stress [0.03%]
慢性轻度不可预测性应激小鼠额叶皮层神经元DNA/RNA氧化水平升高
Alfred M Maluach,Keith A Misquitta,Thomas D Prevot et al.
Alfred M Maluach et al.
Background: Chronic stress is implicated in the development of various psychiatric illnesses including major depressive disorder. Previous reports suggest that patients with major depressive disorder have increased levels...
Anxiolytic effects of buspirone and MTEP in the Porsolt Forced Swim Test [0.03%]
普罗索尔强制游泳实验中巴斯普隆和MTEP的抗焦虑作用
Kaziya M Lee,Michal A Coelho,Kimberly R Sern et al.
Kaziya M Lee et al.
Traditionally, a reduction in floating behavior or immobility in the Porsolt forced swim test (FST) is employed as a predictor of antidepressant efficacy. However, over the past several years, our studies of alcohol withdrawal-induced negat...
Bruce S McEwen
Bruce S McEwen
The brain is the central organ of stress and adaptation to stress because it perceives and determines what is threatening, as well as the behavioral and physiological responses to the stressor, which promote adaptation ("allostasis") but al...
Combat Exposure Severity is Associated with Reduced Cortical Thickness in Combat Veterans: A Preliminary Report [0.03%]
作战经历的严重程度与战斗退伍军人皮质厚度减小有关：初步报告
Lynnette A Averill,Chadi G Abdallah,Robert H Pietrzak et al.
Lynnette A Averill et al.
Background: Chronic stress and related physiological responses are known to have deleterious effects on neural integrity. Combat exposure is a notoriously pathogenic stressor and with over 2 million U.S. troops deployed t...
Biobehavioral Mechanisms of Mindfulness as a Treatment for Chronic Stress: An RDoC Perspective [0.03%]
从RDoC角度看待正念减压对慢性压力的生物行为机制研究
Eric L Garland,Adam W Hanley,Anne K Baker et al.
Eric L Garland et al.
Mindfulness-based interventions have been heralded as promising means of alleviating chronic stress. While meta-analyses indicate that mindfulness-based interventions significantly reduce global measures of stress, how mindfulness-based int...
Characterization of GABAergic marker expression in the chronic unpredictable stress model of depression [0.03%]
慢性不可预测压力模型中抑郁症相关GABA能标记物的表达特征分析
Mounira Banasr,Ashley Lepack,Corey Fee et al.
Mounira Banasr et al.
Evidence continues to build suggesting that the GABAergic neurotransmitter system is altered in brains of patients with major depressive disorder. However, there is little information available related to the extent of these changes or the ...
The Association of PTSD Symptom Severity with Localized Hippocampus and Amygdala Abnormalities [0.03%]
PTSD症状严重程度与海马和杏仁核局部异常的相关性研究
Teddy J Akiki,Christopher L Averill,Kristen M Wrocklage et al.
Teddy J Akiki et al.
Background: The hippocampus and amygdala have been repeatedly implicated in the psychopathology of posttraumatic stress disorder (PTSD). While numerous structural neuroimaging studies examined these two structures in PTSD...
Chadi G Abdallah,Paul Geha
Chadi G Abdallah
Pain and stress share significant conceptual and physiological overlaps. Both phenomena challenge the body's homeostasis and necessitate decision-making to help animals adapt to their environment. In addition, chronic stress and chronic pai...
Laura E Kwako,George F Koob
Laura E Kwako
Addiction has been conceptualized as a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that worsens over time and involves allostatic changes in hedonic function via changes in the brain rewa...