A medial prefrontal cortex cell type necessary and sufficient for a rapid antidepressant response [0.03%]
调控快速抗抑郁反应的内侧前额叶皮层神经元类型
Brendan D Hare,Ronald S Duman
Brendan D Hare
Reduced Salience and Enhanced Central Executive Connectivity Following PTSD Treatment [0.03%]
创伤后应激障碍治疗后的权重降低和中央执行网络连接增强现象
Chadi G Abdallah,Christopher L Averill,Amy E Ramage et al.
Chadi G Abdallah et al.
Background: In soldiers with posttraumatic stress disorder (PTSD), symptom provocation was found to induce increased connectivity within the salience network, as measured by functional magnetic resonance imaging (fMRI) an...
A Review of fMRI Affective Processing Paradigms Used in the Neurobiological Study of Posttraumatic Stress Disorder [0.03%]
用于PTSD神经生物学研究的功能磁共振脑情感加工范式的评价
Alyson M Negreira,Chadi G Abdallah
Alyson M Negreira
Posttraumatic stress disorder (PTSD) is a chronic and debilitating psychiatric disorder with a complex clinical presentation. The last two decades have seen a proliferation of literature on the neurobiological mechanisms subserving affectiv...
Chronic Unpredictable Stress Reduces Immunostaining for Connexins 43 and 30 and Myelin Basic Protein in the Rat Prelimbic and Orbitofrontal Cortices [0.03%]
慢性不可预测压力降低大鼠前额叶皮质缝隙连接蛋白43和30及髓鞘碱性蛋白的免疫印迹反应性
José Javier Miguel-Hidalgo,Mohadetheh Moulana,Preston Hardin Deloach et al.
José Javier Miguel-Hidalgo et al.
Background: Astrocytes and oligodendrocytes are pathologically altered in dorsolateral prefrontal and orbitofrontal cortices in major depressive disorder. In rat models of stress (major depressive disorder risk factor) as...
Reward Ameliorates Posttraumatic Stress Disorder-Related Impairment in Sustained Attention [0.03%]
奖赏改善创伤后应激障碍患者的持续注意力损伤
Sunny J Dutra,Brian P Marx,Regina McGlinchey et al.
Sunny J Dutra et al.
Background: Posttraumatic stress disorder is associated with impairments in sustained attention, a fundamental cognitive process important for a variety of social and occupational tasks. To date, however, the precise natu...
Structural Connectivity of the Posterior Cingulum Is Related to Reexperiencing Symptoms in Posttraumatic Stress Disorder [0.03%]
后扣带回的结构性连接与创伤后应激障碍再体验症状的关系
Carissa N Weis,Emily L Belleau,Walker S Pedersen et al.
Carissa N Weis et al.
Posttraumatic stress disorder (PTSD) is a heterogeneous disorder with disturbances in hyper-arousal or avoidance behaviors, and intrusive or re-experiencing thoughts. The uncinate fasciculus (UF) and cingulum bundle are white matter pathway...
Hydroxynorketamine: Implications for the NMDA Receptor Hypothesis of Ketamine's Antidepressant Action [0.03%]
羟基去甲氯胺酮：氯胺酮抗抑郁作用的N-甲基-D天冬氨酸受体假说的启示
Lily R Aleksandrova,Yu Tian Wang,Anthony G Phillips
Lily R Aleksandrova
The prevailing hypothesis of ketamine's unique antidepressant effects implicates N-methyl-d-aspartate receptor (NMDAR) inhibition-dependent enhancement of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated transmission,...
Ketamine, but Not the NMDAR Antagonist Lanicemine, Increases Prefrontal Global Connectivity in Depressed Patients [0.03%]
氯胺酮而不是NMDAR拮抗剂兰西美新与抑郁患者的前额叶功能连接增强有关
Chadi G Abdallah,Arpan Dutta,Christopher L Averill et al.
Chadi G Abdallah et al.
Background: Identifying the neural correlates of ketamine treatment may facilitate and expedite the development of novel, robust, and safe rapid-acting antidepressants. Prefrontal cortex (PFC) global brain connectivity wi...
Chung Sub Kim,Daniel Johnston
Chung Sub Kim
Growing evidence suggests a possible link between hyperpolarization-activated cyclic nucleotide-gated nonselective cation (HCN) channels and depression. In a recent study published in Molecular Psychiatry, we first demonstrate that I h (the...
Maternal Cerebrospinal Fluid Glutamate in Response to Variable Foraging Demand: Relationship to Cerebrospinal Fluid Serotonin Metabolites in Grown Offspring [0.03%]
母体脑脊液谷氨酸对不同觅食需求的反应及其与后代成年后脑脊液血清素代谢产物的关系
Jeremy D Coplan,Nishant K Gupta,Sarah K Flynn et al.
Jeremy D Coplan et al.
Background: Maternal response to allostatic overload during infant rearing may alter neurobiological measures in grown offspring, potentially increasing susceptibility to mood and anxiety disorders. We examined maternal c...