Structural Connectivity of the Posterior Cingulum Is Related to Reexperiencing Symptoms in Posttraumatic Stress Disorder [0.03%]
后扣带回的结构性连接与创伤后应激障碍再体验症状的关系
Carissa N Weis,Emily L Belleau,Walker S Pedersen et al.
Carissa N Weis et al.
Posttraumatic stress disorder (PTSD) is a heterogeneous disorder with disturbances in hyper-arousal or avoidance behaviors, and intrusive or re-experiencing thoughts. The uncinate fasciculus (UF) and cingulum bundle are white matter pathway...
Hydroxynorketamine: Implications for the NMDA Receptor Hypothesis of Ketamine's Antidepressant Action [0.03%]
羟基去甲氯胺酮：氯胺酮抗抑郁作用的N-甲基-D天冬氨酸受体假说的启示
Lily R Aleksandrova,Yu Tian Wang,Anthony G Phillips
Lily R Aleksandrova
The prevailing hypothesis of ketamine's unique antidepressant effects implicates N-methyl-d-aspartate receptor (NMDAR) inhibition-dependent enhancement of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated transmission,...
Ketamine, but Not the NMDAR Antagonist Lanicemine, Increases Prefrontal Global Connectivity in Depressed Patients [0.03%]
氯胺酮而不是NMDAR拮抗剂兰西美新与抑郁患者的前额叶功能连接增强有关
Chadi G Abdallah,Arpan Dutta,Christopher L Averill et al.
Chadi G Abdallah et al.
Background: Identifying the neural correlates of ketamine treatment may facilitate and expedite the development of novel, robust, and safe rapid-acting antidepressants. Prefrontal cortex (PFC) global brain connectivity wi...
Chung Sub Kim,Daniel Johnston
Chung Sub Kim
Growing evidence suggests a possible link between hyperpolarization-activated cyclic nucleotide-gated nonselective cation (HCN) channels and depression. In a recent study published in Molecular Psychiatry, we first demonstrate that I h (the...
Maternal Cerebrospinal Fluid Glutamate in Response to Variable Foraging Demand: Relationship to Cerebrospinal Fluid Serotonin Metabolites in Grown Offspring [0.03%]
母体脑脊液谷氨酸对不同觅食需求的反应及其与后代成年后脑脊液血清素代谢产物的关系
Jeremy D Coplan,Nishant K Gupta,Sarah K Flynn et al.
Jeremy D Coplan et al.
Background: Maternal response to allostatic overload during infant rearing may alter neurobiological measures in grown offspring, potentially increasing susceptibility to mood and anxiety disorders. We examined maternal c...
Cerebellar and prefrontal cortical alterations in PTSD: structural and functional evidence [0.03%]
PTSD的脑结构与功能异常研究：小脑和前额叶皮层
Sophie E Holmes,Dustin Scheinost,Nicole DellaGioia et al.
Sophie E Holmes et al.
Background: Neuroimaging studies have revealed that disturbances in network organization of key brain regions may underlie cognitive and emotional dysfunction in posttraumatic stress disorder (PTSD). Examining both brain ...
Early Life Stress Associated With Increased Striatal N-Acetyl-Aspartate: Cerebrospinal Fluid Corticotropin-Releasing Factor Concentrations, Hippocampal Volume, Body Mass and Behavioral Correlates [0.03%]
早期生活压力与纹状体N-乙酰天门冬氨酸增多有关：脑脊液促肾上腺皮质激素释放因子浓度、海马体积、体重和行为指标关系研究
Jeremy D Coplan,Dunyue Lu,Alexander M El Sehamy et al.
Jeremy D Coplan et al.
Introduction: Using proton magnetic resonance spectroscopy imaging (1H-MRSI), the effects of early life stress (ELS) on nonhuman primate striatal neuronal integrity were examined as reflected by N-acetyl aspartate (NAA) c...
Neurobiology of Chronic Stress-Related Psychiatric Disorders: Evidence from Molecular Imaging Studies [0.03%]
慢性压力相关精神疾病的神经生物学：分子影像学证据
Margaret T Davis,Sophie E Holmes,Robert H Pietrzak et al.
Margaret T Davis et al.
Chronic stress accounts for billions of dollars of economic loss annually in the United States alone, and is recognized as a major source of disability and mortality worldwide. Robust evidence suggests that chronic stress plays a significan...
Altered Cortical GABA in Female Veterans with Suicidal Behavior: Sex Differences and Clinical Correlates [0.03%]
自杀行为女性退伍军人皮质GABA的改变：性别差异和临床相关性
Andrew Prescot,Chandni Sheth,Margaret Legarreta et al.
Andrew Prescot et al.
Background: Suicide is a public health concern in the civilian and veteran populations. Stressful life events are precipitating factors for suicide. The neurochemical underpinnings of the association between stress/trauma...
The role of stress in the pathogenesis and maintenance of obsessive-compulsive disorder [0.03%]
应激在强迫症的发病机制及维持中的作用
T G Adams,B Kelmendi,C A Brake et al.
T G Adams et al.
Individuals with OCD often identify psychosocial stress as a factor that exacerbates their symptoms, and many trace the onset of symptoms to a stressful period of life or a discrete traumatic incident. However, the pathophysiological relati...