Sex-Dependent Ketamine Addiction-Like Behavior Profile Following Exposure to Chronic Mild Stress [0.03%]
慢性温和应激暴露后氯胺酮引起的性别依赖的药物滥用行为反应差异
Katherine N Wright,Devin P Hagarty,Caroline E Strong et al.
Katherine N Wright et al.
Background: Ketamine has rapid antidepressant effects and shows great promise as a novel treatment for depression, but its limitations including its abuse potential are poorly understood. Given that the prevalence of depr...
Increased Skin Conductance Response in the Immediate Aftermath of Trauma Predicts PTSD Risk [0.03%]
创伤后的皮肤电导反应增强预示PTSD风险
Rebecca Hinrichs,Sanne Jh van Rooij,Vasiliki Michopoulos et al.
Rebecca Hinrichs et al.
Background: Exposure to a traumatic event leads to posttraumatic stress disorder (PTSD) in 10-20% of exposed individuals. Predictors of risk are needed to target early interventions to those who are most vulnerable. The o...
Salience Network Disruption in U.S. Army Soldiers With Posttraumatic Stress Disorder [0.03%]
PTSD患者的优势脑网络损害
Chadi G Abdallah,Christopher L Averill,Amy E Ramage et al.
Chadi G Abdallah et al.
Background: Better understanding of the neurobiology of posttraumatic stress disorder (PTSD) may be critical to developing novel, effective therapeutics. Here, we conducted a data-driven investigation using a well-establi...
A medial prefrontal cortex cell type necessary and sufficient for a rapid antidepressant response [0.03%]
调控快速抗抑郁反应的内侧前额叶皮层神经元类型
Brendan D Hare,Ronald S Duman
Brendan D Hare
Reduced Salience and Enhanced Central Executive Connectivity Following PTSD Treatment [0.03%]
创伤后应激障碍治疗后的权重降低和中央执行网络连接增强现象
Chadi G Abdallah,Christopher L Averill,Amy E Ramage et al.
Chadi G Abdallah et al.
Background: In soldiers with posttraumatic stress disorder (PTSD), symptom provocation was found to induce increased connectivity within the salience network, as measured by functional magnetic resonance imaging (fMRI) an...
A Review of fMRI Affective Processing Paradigms Used in the Neurobiological Study of Posttraumatic Stress Disorder [0.03%]
用于PTSD神经生物学研究的功能磁共振脑情感加工范式的评价
Alyson M Negreira,Chadi G Abdallah
Alyson M Negreira
Posttraumatic stress disorder (PTSD) is a chronic and debilitating psychiatric disorder with a complex clinical presentation. The last two decades have seen a proliferation of literature on the neurobiological mechanisms subserving affectiv...
Chronic Unpredictable Stress Reduces Immunostaining for Connexins 43 and 30 and Myelin Basic Protein in the Rat Prelimbic and Orbitofrontal Cortices [0.03%]
慢性不可预测压力降低大鼠前额叶皮质缝隙连接蛋白43和30及髓鞘碱性蛋白的免疫印迹反应性
José Javier Miguel-Hidalgo,Mohadetheh Moulana,Preston Hardin Deloach et al.
José Javier Miguel-Hidalgo et al.
Background: Astrocytes and oligodendrocytes are pathologically altered in dorsolateral prefrontal and orbitofrontal cortices in major depressive disorder. In rat models of stress (major depressive disorder risk factor) as...
Reward Ameliorates Posttraumatic Stress Disorder-Related Impairment in Sustained Attention [0.03%]
奖赏改善创伤后应激障碍患者的持续注意力损伤
Sunny J Dutra,Brian P Marx,Regina McGlinchey et al.
Sunny J Dutra et al.
Background: Posttraumatic stress disorder is associated with impairments in sustained attention, a fundamental cognitive process important for a variety of social and occupational tasks. To date, however, the precise natu...
Structural Connectivity of the Posterior Cingulum Is Related to Reexperiencing Symptoms in Posttraumatic Stress Disorder [0.03%]
后扣带回的结构性连接与创伤后应激障碍再体验症状的关系
Carissa N Weis,Emily L Belleau,Walker S Pedersen et al.
Carissa N Weis et al.
Posttraumatic stress disorder (PTSD) is a heterogeneous disorder with disturbances in hyper-arousal or avoidance behaviors, and intrusive or re-experiencing thoughts. The uncinate fasciculus (UF) and cingulum bundle are white matter pathway...
Hydroxynorketamine: Implications for the NMDA Receptor Hypothesis of Ketamine's Antidepressant Action [0.03%]
羟基去甲氯胺酮：氯胺酮抗抑郁作用的N-甲基-D天冬氨酸受体假说的启示
Lily R Aleksandrova,Yu Tian Wang,Anthony G Phillips
Lily R Aleksandrova
The prevailing hypothesis of ketamine's unique antidepressant effects implicates N-methyl-d-aspartate receptor (NMDAR) inhibition-dependent enhancement of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated transmission,...